2009
DOI: 10.1152/jn.00124.2009
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Intraperiaqueductal Gray Glycine and d-Serine Exert Dual Effects on Rostral Ventromedial Medulla on- and off-Cell Activity and Thermoceptive Threshold in the Rat

Abstract: ) and painrelated changes on neuronal activity in the rostral ventromedial medulla (RVM). Glycine or D-serine increased the tail-flick latency, reduced OFF-cell pause, and delayed its onset and increased the time between the onset of the OFF-cell pause and the tail withdrawal. Conversely, they decreased the ongoing activity of the ON cell, the tail-flick-induced ON-cell firing, whereas they delayed the onset of increased tail-flick-induced ON-cell firing. Also, glycine or D-serine reduced the interval between … Show more

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Cited by 9 publications
(11 citation statements)
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“…The present results would provide a physiological role of presynaptic glycine receptors in the antinociceptive function mediated by the PAG, as the activation of presynaptic glycine receptors can increase the excitability of PAG neurons by enhancing excitatory glutamatergic transmission. This speculation might be different from previous findings showing that glycine microinjected into the PAG produces hyperalgesic action in a strychnine-sensitive manner [43]. However, the previous behavioral findings might be not applicable to the present study because the microinjected glycine can activate somatodendritic as well as presynaptic glycine receptors within the PAG region.…”
Section: Discussioncontrasting
confidence: 94%
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“…The present results would provide a physiological role of presynaptic glycine receptors in the antinociceptive function mediated by the PAG, as the activation of presynaptic glycine receptors can increase the excitability of PAG neurons by enhancing excitatory glutamatergic transmission. This speculation might be different from previous findings showing that glycine microinjected into the PAG produces hyperalgesic action in a strychnine-sensitive manner [43]. However, the previous behavioral findings might be not applicable to the present study because the microinjected glycine can activate somatodendritic as well as presynaptic glycine receptors within the PAG region.…”
Section: Discussioncontrasting
confidence: 94%
“…For example, a previous study has shown that the microinjection of glycine into the dorsal PAG of rats increases tail-flick latencies in a dose-dependent manner, and this hyponociceptive effect of glycine is reversed by coadministration with the specific inhibitor for NMDA receptor glycine site [42], suggesting that microinjected glycine acts on glycine-binding site of NMDA receptors to elicit hyponociception. In addition, a recent study has shown that the microinjection of glycine into the ventrolateral PAG of rats produces conflicting results, for example, hyperalgesia or analgesia [43]. In this study, while the glycine-induced analgesia is blocked by the NMDA receptor antagonist, the glycine-induced hyperalgesia is blocked by the glycine receptor antagonist [43], suggesting that glycine acts as an excitatory transmitter, for example, coagonist for NMDA receptors, to increase the excitability of output PAG neurons.…”
Section: Discussionmentioning
confidence: 99%
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“…KYNA was also able to inhibit the activation of the LC neurones evoked by stimulation of nucleus paragigantocellularis [57], which causes increased levels of EAAs in the LC [57, 58]. Furthermore, 7-CK prevented nociceptive behaviour (tail-flick) and pain-related changes in neuronal activity induced in the rostral ventromedial medulla by glycine or D-serine administration into the ventrolateral PAG [173]; the co-administration of KYNA with morphine in the same area enhanced the acute antinociceptive effects of morphine [174]. These results demonstrate that the kynurenine metabolites, are particularly KYNA and its derivatives, can give rise to antinociceptive effects through their influence on higher brain areas.…”
Section: Kynurenine Metabolites and Migrainementioning
confidence: 99%
“…Bearing in mind that glutamate is the main excitatory neurotransmitter and that g-aminobutyric acid (GABA) and glycine act as the main inhibitory neurotransmitters, a dynamic characterization of amino acids is especially valuable for understanding the pain modulation system. 6,13,15,31 Evidence is emerging that excitatory and inhibitory amino acids play important functional roles in the PAG and in other brain centers involved in pain modulation. 13,15,20,25 Although there is both clinical and experimental evidence that these amino acids are involved in pain transmission, 13,15,20,25,26,31,34 the mechanism underlying the analgesic effect of MCS on neurotransmitter release in the PAG remains unclear, and very little is known about the functions of the amino acids in the modulatory system of pain in the PAG.…”
mentioning
confidence: 99%