A cardiac lipoma and a cardiac liposarcoma are very uncommon conditions; however, the simultaneous development of the two is extremely rare. In addition, the symptoms of these conditions are not evident in the vast majority of cases, making them easily missed during diagnosis. The present case report describes a case of well-differentiated cardiac liposarcoma with a concomitant myocardial lipoma that was misdiagnosed as multiple cardiac lipomas. The ultrasound, computed tomography, and magnetic resonance imaging presentations of the tumour were described. In addition, relevant literature regarding these two types of tumours was reviewed and compared in order to help improve the identification of these types of tumours. This, in turn, may be beneficial in the selection of more appropriate examination and treatment strategies.