Intrapericardial paragangliomas (pheochromocytomas): imaging features.

Hamilton, Brian H.; Francis, I R; Gross, B H; Korobkin, Melvyn; Shapiro, Brahm; Shulkin, Barry L.; Deeb, C M; Orringer, Mark B.

doi:10.2214/ajr.168.1.8976931

Cited by 86 publications

(63 citation statements)

References 11 publications

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“…Our patient's levels were all within the normal range. Radioactive iodine-labeled metaiodobenzylguanidine scintigraphy has also been used to diagnose these active tumors with reported elevated sensitivities >85% and specificity of 100% as reported by several authors, 17 but in this above mentioned study from Mayo, the false negative rates for metaiodobenzylguanidine was 39%. 15 There have also been some reports of localization of hyper functional paragangliomas with 18F fluorodeoxyglucose, fluorodeoxyglucose-positron emission tomography, and Tc-99m Octreotide scans.…”

Section: 10mentioning

confidence: 58%

Cardiac Paraganglioma

Yadav

Baquero

Malysz

et al. 2014

Circ: Cardiovascular Interventions

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Paragangliomas are extraadrenal tumors that arise from chromaffin cells of the sympathetic ganglia. Cardiac paraganglia are exceptionally rare and because of paucity of cohort data, raises dilemmas about management when encountered. Some of them are metabolically active and may present with symptoms of catecholamine excess, whereas some may be incidentally diagnosed. In this report, we discuss the challenges surrounding the diagnosis and management of a cardiac paraganglioma at each stage. Case PresentationA 73-year-old woman is referred by her cardiologist for an elective coronary angiography because of an abnormal stress test in the setting of dyspnea on exertion. The dyspnea started ≈6 months ago and has been slowly progressive. She continues to try to exercise through this and is currently able to walk 1 mile in 30 minutes, a pace that is slower than usual. The medical history is significant for mild edema (hydrochlorothiazide 25 mg/d), dyslipidemia (diet controlled); there is no history of smoking, hypertension, diabetes mellitus, coronary artery disease, or peripheral atherosclerosis. Her family history is notable for coronary artery disease.On physical examination, the patient's body mass index is 35 (5 ft 0 in; 81.6 kg), blood pressure is 140/70 mm Hg with a pulse of 60 bpm. Jugular venous pulse is normal. Carotid upstroke is brisk, and there are no bruits. Lungs are clear to auscultation. The first and the second heart sounds are normal; there are no murmurs, rubs, or gallops. There is no lower extremity edema, and rest of the examination is unremarkable. An ECG demonstrates normal sinus rhythm with possible anteroseptal infarct. A chest radiograph is normal.The stress echocardiography report shows that the patient exercised for 7:30 minutes on a Bruce protocol achieving a peak heart rate of 146 bpm (99% maximum predicted heart rate) and blood pressure of 180/60 mm Hg. The resting heart rate and blood pressure were 71 bpm and 118/60 mm , respectively. The resting ECG showed normal sinus rhythm with possible anteroseptal infarct, and the stress ECG showed sinus tachycardia with nonspecific ST-T wave changes. The resting part of stress echocardiography showed normal wall motion, and with exercise, the left ventricle became smaller and more vigorous, but the anterior septum and septum failed to become hyperkinetic, and therefore the study was read as an abnormal study. The patient was then referred to a cardiologist for further evaluation. Certainly, the stress test abnormality was not high risk, and a trial of medical therapy with investigation of alternate pathogenesis for dyspnea versus diagnostic coronary angiography was discussed. However, the patient's symptoms were out of proportion to the degree of stress test abnormality, with no other obvious pathogenesis. The patient was concerned about ischemic heart disease in light of not a normal stress test, and decision was made to proceed with a diagnostic coronary angiography.At this time, the patient undergoes coronary angiography via transradial access...

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Section: 10mentioning

confidence: 58%

Cardiac Paraganglioma

Yadav

Baquero

Malysz

et al. 2014

Circ: Cardiovascular Interventions

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“…Katekolamin sekresyonu yapan paragangliyomlar genel popülasyonun %0.01-0.001'inde görülmekle birlikte, yetişkinlerde görülen hipertansiyonun %1'inden sorumludur. [7] Paragangliomlar Von Hippel Lindau, MEN II, Corney sendromu gibi ailesel bazı sendromlarla birlikte bulunabilirler. [8] Adrenal dışı paragangliomlarda malignite insidansı %20-40 olup, adrenal paragangliomlardan daha fazladır (%2-10).…”

Section: Discussionunclassified

Treatment approach of metastatic paraganglioma: Case report

Ekici¹,

Mayadağlı²,

Gül³

et al. 2011

J Kartal TR

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“…A catecholamine-producing intrapericardial paraganglioma has never been described previously in the context of multiple endocrine neoplasia (MEN) IIA syndrome. 1,2 We report the case of a patient with MEN IIA syndrome and secondary hypertension caused by functioning paraganglioma exceptionally located intrapericardially.…”

Section: Hypertension and Intrapericardialmentioning

confidence: 99%