Intraperitoneal Administration of a Cisplatin-Loaded Nanogel through a Hybrid System Containing an Alginic Acid-Based Nanogel and an <i>In Situ</i> Cross-Linkable Hydrogel for Peritoneal Dissemination of Ovarian Cancer

Yamaguchi, Kohei; Wada-Hiraike, Osamu; Iwaki, Haruna; Matsumiya, Kazuki; Nakamura, Noriko; Sone, Kenbun; Ohta, Seiichi; Osuga, Yutaka; Ito, Taichi

doi:10.1021/acs.molpharmaceut.1c00514

Cited by 24 publications

(13 citation statements)

References 47 publications

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“…Moreover, it has the specific ability to form hydrogels with a high water content that makes them similar to native soft tissue. The alginate-based hybrid system of cisplatin-loaded alginate nanogel encapsulated in an injectable alginate hydrogel crosslinked with calcium ions for the treatment of ovarian cancer was developed [ 66 ]. To form the cisplatin-loaded alginate nanogel, cisplatin (6 mg/mL) was mixed with an aqueous solution of alginate (2.0 mg/mL), heated at 95 °C, dialyzed and lyophilized.…”

Section: Alginate-based Hydrogels and Scaffolds For Cancer Treatmentmentioning

confidence: 99%

Alginate-Based Hydrogels and Scaffolds for Biomedical Applications

et al. 2023

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Alginate is a natural polymer of marine origin and, due to its exceptional properties, has great importance as an essential component for the preparation of hydrogels and scaffolds for biomedical applications. The design of biologically interactive hydrogels and scaffolds with advanced, expected and required properties are one of the key issues for successful outcomes in the healing of injured tissues. This review paper presents the multifunctional biomedical applications of alginate-based hydrogels and scaffolds in selected areas, highlighting the key effect of alginate and its influence on the essential properties of the selected biomedical applications. The first part covers scientific achievements for alginate in dermal tissue regeneration, drug delivery systems, cancer treatment, and antimicrobials. The second part is dedicated to our scientific results obtained for the research opus of hydrogel materials for scaffolds based on alginate in synergy with different materials (polymers and bioactive agents). Alginate has proved to be an exceptional polymer for combining with other naturally occurring and synthetic polymers, as well as loading bioactive therapeutic agents to achieve dermal, controlled drug delivery, cancer treatment, and antimicrobial purposes. Our research was based on combinations of alginate with gelatin, 2-hydroxyethyl methacrylate, apatite, graphene oxide and iron(III) oxide, as well as curcumin and resveratrol as bioactive agents. Important features of the prepared scaffolds, such as morphology, porosity, absorption capacity, hydrophilicity, mechanical properties, in vitro degradation, and in vitro and in vivo biocompatibility, have shown favorable properties for the aforementioned applications, and alginate has been an important link in achieving these properties. Alginate, as a component of these systems, proved to be an indispensable factor and played an excellent “role” in the optimal adjustment of the tested properties. This study provides valuable data and information for researchers and demonstrates the importance of the role of alginate as a biomaterial in the design of hydrogels and scaffolds that are powerful medical “tools” for biomedical applications.

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Section: Alginate-based Hydrogels and Scaffolds For Cancer Treatmentmentioning

confidence: 99%

Alginate-Based Hydrogels and Scaffolds for Biomedical Applications

et al. 2023

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“… Yamaguchi et al (2021) designed a cisplatin (CDDP)-loaded nanogel for peritoneally disseminated ovarian cancer to ensure adequate exposure of ovarian cancer cells to optimum concentrations of cisplatin. They developed “an alginate (AL)-based hybrid system in which a CDDP-loaded AL nanogel (AL/CDDP-nanogel) was encapsulated in an injectable AL-hydrogel cross-linked with calcium ions.” This matrix prevented the rapid clearance of CDDP and facilitated a sustained release of CDDP from the nanogel hybrid for over 1 week.…”

Section: Nanogels For Cancer Therapymentioning

confidence: 99%

“…An in vitro assay with a CD44 blocking/neutralizing antibody revealed that "hyaluronan receptor was involved in the nanogel internalization process." 2.5.9.4 Cisplatin-loaded nanogel for peritoneally disseminated ovarian cancer Yamaguchi et al (2021) designed a cisplatin (CDDP)-loaded nanogel for peritoneally disseminated ovarian cancer to ensure adequate exposure of ovarian cancer cells to optimum concentrations of cisplatin. They developed "an alginate (AL)based hybrid system in which a CDDP-loaded AL nanogel (AL/ CDDP-nanogel) was encapsulated in an injectable AL-hydrogel cross-linked with calcium ions."…”

Section: Nanogel Formulations For Ovarian Cancer Therapymentioning

confidence: 99%

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

et al. 2022

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Cancer is an important cause of morbidity and mortality worldwide, irrespective of the level of human development. Globally, it was estimated that there were 19.3 million new cases of cancer and almost 10 million deaths from cancer in 2020. The importance of prevention, early detection as well as effective cancer therapies cannot be over-emphasized. One of the important strategies in cancer therapy is targeted drug delivery to the specific tumor sites. Nanogels are among the several drug delivery systems (DDS) being explored as potential candidates for targeted drug delivery in cancer therapy. Nanogels, which are new generation, versatile DDS with the possession of dual characteristics of hydrogels and nanoparticles have shown great potential as targeted DDS in cancer therapy. Nanogels are hydrogels with a three-dimensional (3D) tunable porous structure and a particle size in the nanometre range, from 20 to 200 nm. They have been visualized as ideal DDS with enormous drug loading capacity, and high stability. Nanogels can be modified to achieve active targeting and enhance drug accumulation in disease sites. They can be designed to be stimulus-responsive, and react to internal or external stimuli such as pH, temperature, light, redox, thus resulting in the controlled release of loaded drug. This prevents drug accumulation in non-target tissues and minimizes the side effects of the drug. Drugs with severe adverse effects, short circulation half-life, and easy degradability by enzymes, such as anti-cancer drugs, and proteins, are suitable for delivery by chemically cross-linked or physically assembled nanogel systems. This systematic review summarizes the evolution of nanogels for targeted drug delivery for cancer therapy over the last decade. On-going clinical trials and recent applications of nanogels as targeted DDS for cancer therapy will be discussed in detail. The review will be concluded with discussions on safety and regulatory considerations as well as future research prospects of nanogel-targeted drug delivery for cancer therapy.

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“…Hydrogels are polymers with a three-dimensional network structure formed by covalent bonds, hydrogen bonds, van der Waals force, or ionic bonds. [1][2][3][4][5][6][7] With the advantages of adhesion, biocompatibility, and degradability, hydrogels are biomaterials with excellent performance and have important applications in tissue engineering, [8][9][10] wound dressing, [11][12][13][14] drug delivery, [15][16][17][18][19] and so on. Hydrogels can be divided into intelligent hydrogels and non-intelligent hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Temperature‐/pH‐Responsive Hydrogels for Drug Delivery

et al. 2023

ChemistrySelect

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A temperature-/pH-responsive hydrogel was successfully prepared by in situ free radical polymerization of N-isopropyl acrylamide (NIPAm), itaconic acid (IA), and poly (ethylene glycol) methyl ether acrylate (OEGA). The pore size, mechanical strength, and swelling ratio of the P(NIPAm-IA-OEGA) were strongly affected by the contents of IA. 5-Fluorouracil (5-Fu) was chosen as a model drug, and the maximum drug loading was 68 mg/g. P(NIPAm-IA-OEGA) had a much greater release rate in a simulated intestinal fluid environment (47.73 %, 16 h) than in gastric juice (33.11 %, 16 h). The hemolysis test and cytotoxicity test proved that prepared hydrogel had good biocompatibility. In summary, P(NIPAm-IA-OEGA) can be used for oral drug delivery systems in cancer therapy.

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Intraperitoneal Administration of a Cisplatin-Loaded Nanogel through a Hybrid System Containing an Alginic Acid-Based Nanogel and an In Situ Cross-Linkable Hydrogel for Peritoneal Dissemination of Ovarian Cancer

Cited by 24 publications

References 47 publications

Alginate-Based Hydrogels and Scaffolds for Biomedical Applications

Alginate-Based Hydrogels and Scaffolds for Biomedical Applications

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

Synthesis and Characterization of Temperature‐/pH‐Responsive Hydrogels for Drug Delivery

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