Intraperitoneal bupivacaine for pain relief after minilaparoscopy in patients with infertility

Roy, Kallol Kumar; Subbaiah, Murali; Naha, Moumita; Kumar, Sunesh; Sharma, Jai Bhagwan; Jahagirdar, Nandini Joshi Nee

doi:10.1007/s00404-013-2994-6

Cited by 16 publications

(10 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,2 This technique reduces early postoperative analgesic requirements, pain scores, and time to firstintervention analgesia after abdominal surgery in humans. [3][4][5][6][7][8][9][10][11][12] According to meta-analyses and systematic reviews, IP administration of bupivacaine currently is recommended for laparoscopic surgery in humans as an adjuvant analgesic technique. 3,[13][14][15][16] Intraperitoneal administration of bupivacaine can reduce pain scores and blunt surgery-induced stress responses in dogs undergoing ovariohysterectomy.…”

mentioning

confidence: 99%

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Benito¹,

Monteiro²,

Beaudry³

et al. 2016

ajvr

View full text Add to dashboard Cite

OBJECTIVE To evaluate pharmacokinetics of bupivacaine after IP administration to cats undergoing ovariohysterectomy. ANIMALS 8 healthy cats. PROCEDURES Anesthesia was induced with propofol and maintained with isoflurane. Buprenorphine (0.02 mg/kg, IV) and meloxicam (0.2 mg/kg, SC) were administered. A 20-gauge catheter was inserted into a jugular vein for blood sample collection. A ventral midline incision was made, and a solution of 0.5% bupivacaine (2 mg/kg) diluted with an equal volume of saline (0.9% NaCl) solution (final concentration, 0.25% bupivacaine) was injected into the peritoneal space over the right and left ovarian pedicles and caudal aspect of the uterus before ovariohysterectomy. Cats were monitored for signs of bupivacaine toxicosis. Venous blood samples (2 mL) were collected before (time 0) and 2, 5, 10, 15, 20, 30, 60, 120, and 240 minutes after bupivacaine administration. Plasma bupivacaine concentrations were determined with a liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were determined by data plotting followed by analysis with a noncompartmental model. RESULTS No signs of bupivacaine toxicosis were observed. Maximum bupivacaine plasma concentration was 1,030 ± 497.5 ng/mL at a mean ± SD value of 30 ± 24 minutes after administration. Mean elimination half-life was 4.79 ± 2.7 hours. Mean clearance indexed by bioavailability and volume of distribution indexed by bioavailability were 0.35 ± 0.18 L•h/kg and 2.10 ± 0.84 L/kg, respectively. CONCLUSIONS AND CLINICAL RELEVANCE Intraperitoneal administration of bupivacaine resulted in concentrations that did not cause observable toxicosis. Studies to investigate analgesic effects for this technique in cats are warranted.

show abstract

mentioning

confidence: 99%

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Benito¹,

Monteiro²,

Beaudry³

et al. 2016

ajvr

View full text Add to dashboard Cite

show abstract

“…Theoretical backgrounds for the use of local anesthetic are blocking the input of noxious stimuli that trigger neuronal excitability and inhibiting the nervous system sensitization [ 24 ]. Several studies have shown the benefit of bupivacaine in reducing postoperative pain after conventional laparoscopic gynecologic surgery or mini-laparotomy when intraperitoneal administration is used [ 17 21 ]. Meanwhile, the incisional sites injection alone did not demonstrate significant benefit [ 16 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…This hypothesis was defined by comparing the mean VAS pain scores between the 2 groups. A mean difference between the 2 groups of 2 VAS pain scores was deemed clinically relevant, and the standard deviation was expected to be 3.5, based on the previous published report [ 17 ]. Given these assumptions, a sample size of 65 subjects per group provided 90% statistical power to detect a mean difference of 2 VAS pain scores points between the groups at any given time point using a 2-sided test having a significance level of 0.05.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Port site infiltration of local anesthetic after laparoendoscopic single site surgery for benign adnexal disease

et al. 2017

View full text Add to dashboard Cite

ObjectiveTo determine whether local bupivacaine injection into the incision site after gynecologic laparoendoscopic single site surgery (LESS) improves postoperative pain.MethodsThis prospective cohort study included consecutive 158 patients who had LESS for benign adnexal disease from March 2013 to December 2015. Chronologically, 82 patients (March 2013 to August 2014) received no bupivacaine (group 1) and 76 (August 2014 to December 2015) received a bupivacaine block (group 2). For group 2, 10 mL 0.25% bupivacaine was injected into the 20 mm-incision site through all preperitoneal layers after LESS completion. Primary outcome is postoperative pain score using the visual analog scale (VAS).ResultsThere was no difference in clinicopathological characteristics between the groups. Operating time (expressed as median [range], 92 [55–222] vs. 100 [50–185] minutes, P=0.137) and estimated blood loss (50 [30–1,500] vs. 125 [30–1,000] mL, P=0.482) were similar between the groups. Post-surgical VAS pain scores after 3 hours (3.5 [2–6] vs. 3.5 [2–5], P=0.478), 6 to 8 hours (3.5 [2–6] vs. 3 [1–8], P=0.478), and 16 to 24 hours (3 [2–4] vs. 3 [1–7], P=0.664) did not differ between groups.ConclusionBupivacaine injection into the trocar site did not improve postoperative pain after LESS. Randomized trials are needed to evaluate the benefits of local bupivacaine anesthetic for postoperative pain reduction.

show abstract

“…However, spinal anesthesia is accompanied with neurologic deficits, such as cauda equina syndrome, low blood pressure, bradycardia, headache, and back and shoulder pain [ 2 , 3 ]. The complications will be less observed if an appropriate dose is selected, anesthesia level is controlled, and sterilization is met [ 4 ]. The most important problem of laparoscopy under spinal anesthesia is Trendelenburg's position and upper abdominal pressure, which lead to neck and shoulder pain in a few minutes after starting the pneumoperitoneum, caused by nervous stimulation of the diaphragm and phrenic nerve [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Spinal Anesthesia and Spinal Anesthesia with Subdiaphragmatic Lidocaine in Shoulder Pain Reduction for Gynecological Laparoscopic Surgery: A Randomized Clinical Trial

Asgari

Rezaeinejad

Hosseini

et al. 2017

Pain Research and Management

View full text Add to dashboard Cite

Objective The aim of this study was to compare the effectiveness of spinal anesthesia with subdiaphragmatic lidocaine at the beginning of surgery versus spinal anesthesia in pain reduction for gynecological laparoscopic surgery. Methods This was a clinical trial conducted in Arash Hospital, Tehran, Iran. Eighty-four patients were randomized to either spinal anesthesia with subdiaphragmatic lidocaine, spinal anesthesia, or general anesthesia (GA). The primary outcome was patients' pain perception during surgery, 2, 4, 6, and 12 hours after surgery, and prior to discharge and was assessed by visual analogue scale (VAS). Results The results showed that there are no significant changes in pain perception over time in none of the three groups (F(4,76) = 0.37, P = 0.82). The severity of pain experienced by patients at all-time interval after surgery was similar between groups [F(2,79) = 0.54, P = 0.58]. Conclusion The use of subdiaphragmatic lidocaine at the beginning of surgery combined with spinal anesthesia was not associated with a statistically significant difference in patients' postoperative VAS scores compared to spinal anesthesia and GA during and after gynecological surgical procedures. The study was registered in Iranian Registry of Clinical Trial by the number of IRCT2016022226698N1.

show abstract

Intraperitoneal bupivacaine for pain relief after minilaparoscopy in patients with infertility

Abstract: Post operative intraperitoneal bupivacaine administration is beneficial for patients undergoing diagnostic minilaparoscopy. It can significantly decrease post operative pain for up to 8 h and reduce the need for additional analgesics.

Cited by 16 publications

References 9 publications

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Port site infiltration of local anesthetic after laparoendoscopic single site surgery for benign adnexal disease

Spinal Anesthesia and Spinal Anesthesia with Subdiaphragmatic Lidocaine in Shoulder Pain Reduction for Gynecological Laparoscopic Surgery: A Randomized Clinical Trial

Contact Info

Product

Resources

About