Intraperitoneal cisplatin and regional hyperthermia for ovarian carcinoma

Leopold, Kenneth A.; Oleson, James R.; Clarke‐Pearson, Daniel L.; Soper, John T.; Berchuck, Andrew; Samulski, Thaddeus V.; Page, R L; Blivin, Janye L.; Tomberlin, Janice K.; Dewhirst, Mark W.

doi:10.1016/0360-3016(93)90550-f

Cited by 27 publications

(5 citation statements)

References 13 publications

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“…22). For clinical application, where intratumoral temperature does not exceed 42°C during the treatment time, the need for TSLs for mild hyperthermia in the range of 40 -42°C is obvious (11,(23)(24)(25). Time-averaged temperatures of 41°C can be achieved easily in 50% of all of the measured tumor sites in the clinical setting (11).…”

Section: Introductionmentioning

confidence: 99%

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Lindner

Eichhorn

Eibl

et al. 2004

Clinical Cancer Research

242

157

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Hyperthermia increases the efficiency of various chemotherapeutic drugs and is administered as an adjunct to chemotherapy for the treatment of cancer patients. The temperature-dependent effect can be strongly increased by the use of temperature-sensitive liposomes in combination with regional hyperthermia, which specifically releases the entrapped drug in the heated tumor tissue. The novel lipid 1.2-dipalmitoyl-sn-glycero-3-phosphoglyceroglycerol (DPP-GOG), which is closely related to the naturally occurring 1.2-dipalmitoyl-sn-glycero-3-phosphoglycerol, in combination with 1.2-dipalmitoyl-sn-glycero-3-phosphocholine and 1.2-distearoyl-sn-glycero-3-phosphocholine provides longcirculating temperature-sensitive liposomes with favorable properties under mildly hyperthermic conditions (41-42°C). DPPGOG facilitates temperature-triggered drug release from these liposomes (diameter, 175 nm) and leads to a substantially prolonged plasma half-life for the encapsulated drug with t 1/2 ‫؍‬ 9.6 h in hamsters and t 1/2 ‫؍‬ 5.0 h in rats. Quantitative fluorescence microscopy of amelanotic melanoma grown in the transparent dorsal skin fold chamber of hamsters demonstrated a favorable drug accumulation in heated tissue after i.v. application of these liposomes (42°C for 1 h). The mean area under the curve for tissue drug concentration was increased by more than sixfold by application of the new liposomes compared with nonliposomal drug delivery. In summary, we present a new DPPGOGbased liposomal formulation enabling long circulation time combined with fast and efficient drug release under mild hyperthermia. This adds positively to the results with lipidgrafted polyethylenglycol used thus far in temperaturesensitive liposomes and widens the possibilities for clinical applications.

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Section: Introductionmentioning

confidence: 99%

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Lindner

Eichhorn

Eibl

et al. 2004

Clinical Cancer Research

242

157

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“…Cisplatin is believed to interact with DNA resulting in both interstrand and intrastrand crosslinks [6], and the temperature enhancement of cisplatin's genotoxicity agrees with observations made by oncologists that the antineoplastic agent has greater cytotoxicity and enhanced antitumorigenicity at elevated temperatures [7,8]. The increased bioactivity of cisplatin observed with elevated temperature has been attributed to a variety of different mechanisms, including (1) an increase in the cisplatin-DNA reaction kinetics [9], and (2) an increase in the cellular uptake of the compound and a resultant increase in DNA adduct formation [10,11].…”

Section: Discussionmentioning

confidence: 59%

Modulation by temperature of the genotoxic potency of cisplatin in drosophila wing spot assay

Katz

1998

Teratog. Carcinog. Mutagen.

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“…Furthermore, both patients who were potentially platinum sensitive and had at least one “good” thermochemotherapy session are alive 43 and 40 months later without evidence of disease in the abdomen. In a similar setting, but with cisplatin, Leopold et al (33) achieved the desired temperature in only 10% of the cases. These results demonstrate that a closed‐abdomen technique with local anesthesia is not simple, since it is usually not tolerated.…”

Section: Discussionmentioning

confidence: 99%

Intraperitoneal hyperthermic chemotherapy in ovarian cancer

Gori¹,

Castaño²,

Toziano³

et al. 2005

Int J Gynecol Cancer

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We investigated the effect of intraperitoneal hyperthermic perfusion chemotherapy as consolidation therapy in stage IIIB-IIIC ovarian cancer, following cytoreductive surgery and systemic chemotherapy (cisplatin-cyclophosphamide--six cycles). Disease-free survival, overall survival, and side effects were compared with a control group of patients who refused a second-look surgery and intraperitoneal chemotherapy. In a multicenter prospective trial, 29 patients with complete or optimal cytoreductive surgery and systemic treatment were included in the consolidation group and received intraperitoneal hyperthermic perfusion chemotherapy. Patients were recruited between January 1991 and December 1997. The intraperitoneal hyperthermic perfusion was performed with open-abdomen technique, using physiologic solution containing cisplatin 100 mg/m2, for 60 min in hyperthermic phase (41-43 degrees C). Intraperitoneal hyperthermic perfusion chemotherapy was locally and systemically well tolerated. The consolidation therapy group showed a better 5-year survival rate and lower recurrent disease rate, but differences were not statistically significant. Our results suggest that intraperitoneal hyperthermic perfusion chemotherapy is a feasible, well-tolerated, and promising alternative as consolidation therapy in ovarian cancer.

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Intraperitoneal cisplatin and regional hyperthermia for ovarian carcinoma

Cited by 27 publications

References 13 publications

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

Modulation by temperature of the genotoxic potency of cisplatin in drosophila wing spot assay

Intraperitoneal hyperthermic chemotherapy in ovarian cancer

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