Intraperitoneal<i>N</i>-acetylcysteine for acute iron intoxication in rats

Breitbart, Rachelle; Abu-Kishk, Ibrahim; Kozer, Eran; Ben‐Assa, Eyal; Goldstein, Lee H.; Youngster, Ilan; Berkovitch, Matitiahu

doi:10.3109/01480545.2011.564176

Cited by 5 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intravenous NAC was used in an adult patient with hepatotoxicity secondary to iron overdose who survived . Animal studies suggest oral NAC may increase iron absorption in the gastrointestinal tract and may increase mortality; however, intraperitoneal NAC was beneficial in decreasing serum iron levels and mortality . Our patients did not appear to respond to NAC and developed progressive hepatic failure despite treatment with NAC.…”

Section: Discussionmentioning

confidence: 67%

Pediatric liver transplantation for fulminant hepatic failure secondary to intentional iron overdose

Lai

Chu

Arnon

2017

Pediatric Transplantation

View full text Add to dashboard Cite

Acute iron poisoning may lead to life-threatening hepatotoxicity. We present the cases of two pediatric patients with hepatotoxicity following intentional iron ingestion that progressed rapidly to fulminant hepatic failure despite treatment with deferoxamine. Liver transplantation was lifesaving in both patients. These cases emphasize the need for a high index of suspicion for iron ingestion, close monitoring for liver toxicity, and timely consideration for liver transplantation.

show abstract

Section: Discussionmentioning

confidence: 67%

Pediatric liver transplantation for fulminant hepatic failure secondary to intentional iron overdose

Lai

Chu

Arnon

2017

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…injection of distilled water (1.0 ml/kg/day) is also administered for the duration of the experiment; -Group III (NAC n = 8): rats were allowed to drink tap water and received an I.P. injection of NAC (150 mg/kg/day) (19,20) daily for the duration of the experiment. -Group IV (protection, n = 8): rats were allowed to drink 60% FS instead of tap water and given a daily I.P.…”

Section: Experimental Substancesmentioning

confidence: 99%

“…-Group IV (protection, n = 8): rats were allowed to drink 60% FS instead of tap water and given a daily I.P. injection of NAC (150 mg/kg/day) [19,20] from the first week until the last week of the experiment (12 weeks); -Group V (treatment n = 8): rats were given an I.P injection of distilled water (1.0 ml/kg/day) and drank 60% FS instead of tap water for the first 8 weeks (17,18) to induce MetS. From the 9 th to the 12 th week of the experiment, the group was allowed to drink tap water and given an I.P.…”

Section: Experimental Substancesmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the Effects of N-Acetylcysteine on Serum Glucose, Lipid Profile, and Body weight In rats With Fructose-Induced Metabolic Syndrome

Yahya¹,

Taqa²,

Alkataan³

2023

Mil. Med. Sci. Lett.

View full text Add to dashboard Cite

Background: Overconsumption of fructose may cause metabolic syndrome (MetS). MetS pathogenesis is caused by oxidative stress, cellular malfunction, and systemic inflammation caused by hereditary and environmental factors. N-acetylcysteine (NAC) has become associated with the phrase "antioxidant." Most researchers use and test NAC with the goal of preventing or reducing oxidative stress. Aim: To determine the positive effects of NAC on blood glucose, lipid profile, and body weight in fructoseinduced metabolic syndrome in albino rats. Materials and Methods: Forty male albino rats, 10-12 weeks old, were haphazardly divided into five groups of identical size. Group I (negative control) received tap water for 12 weeks. Group II (positive control) received a 60% w/w fructose solution (60% FS) instead of tap water for 12 weeks. Group III (NAC) received tap water and an intra-peritoneal (IP) injection of NAC (150 mg/kg/day) for 12 weeks. Group IV (protection) co-administered 60% FS orally and NAC IP injection (150 mg/kg/day) for 12 weeks. Group V (treatment) received 60% FS for 8 weeks followed by 4 weeks of drinking tap water with NAC IP injection (150 mg/kg/day). Blood samples were taken at weeks 0, 8, and 12 and were tested for serum glucose and lipid profile. All animals of each group were weighted at weeks 0, 8 and 12 of the study. Results: Concerning serum glucose, group II showed increased glycaemia at week 8 and further elevation during week 12. Group III displayed normal glycaemia at weeks 8 and 12. In group IV, glycaemia showed elevation at week 8 followed by almost complete restoration at week 12. In group V, there was an increased glycaemia at week 8 followed by a partial restoration at week 12. Regarding lipid profile parameters, group II demonstrated a deterioration during week 8 and more worsening during week 12. There were no significant changes in group III's parameters during weeks 8 and 12. Group IV displayed a worsening in lipid profile during week 8 followed by a nearly complete improvement during week 12. During week 8, group V deteriorated, followed by a partial recovery during week 12. Concerning body weight, group II showed a weight gain at week 8 and further elevation during week 12. Group III displayed normal glycaemia at weeks 8 and 12. In group IV, glycaemia showed elevation at week 8 followed by almost complete restoration at week 12. Yahya et al: N-acetylcysteine's effects on serum glucose, lipid profile, and body weight in rats 195In group V, there was an increased glycaemia at week 8 followed by a partial restoration at week 12. At week 8, there was a significant elevation in body weights in groups II and V compared to group I. Moreover, a significant reduction in body weight was recorded in group IV compared to group II during week 8. At week 12, a significant elevation in body weight was noticed in groups II and V compared to group I. Moreover, there was a significant reduction in body weight in group III compared to group I. On the other hand, there was a significant fall in body weigh...

show abstract

The Acute Effect of Humic Acid on Iron Accumulation in Rats

Çağın

Şahin

Polat

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

Free iron leads to the formation of pro-oxidant reactive oxygen species (ROS). Humic acids (HAs) enhance permeability of cellular wall and act as a chelator through electron transferring. This study was designed to test chelator effect of HA on iron as well as its anti-oxidant effect against the iron-induced hepatotoxicity and cardiotoxicity. The rats used were randomly divided into four groups (n = 8/group): group I (the control group); group II (the HA group), humic acid (562 mg/kg) was given over 10 days by oral gavage; group III (the iron group), iron III hydroxide polymaltose (250 mg/kg) was given over 10 days by intraperitoneal route; and group IV (the HA plus iron group), received the iron (similar to group II) plus humic acid (similar to those in groups II and III) group. Blood and two tissue samples both from liver and heart were obtained for biochemical and histopathological evaluations. Iron deposition, the iron-induced hepatotoxicity, and cardiotoxicity were demonstrated by histopathological and biochemical manner. However, no significant differences were observed in the serum biochemical values and the histopathological results among the iron and the HA plus iron groups in the liver tissue but not in the heart tissue. The protective effects of humic acid against iron-induced cardiotoxicity were shown but not against hepatotoxicity in our study.

show abstract

IntraperitonealN-acetylcysteine for acute iron intoxication in rats

Cited by 5 publications

References 22 publications

Pediatric liver transplantation for fulminant hepatic failure secondary to intentional iron overdose

Pediatric liver transplantation for fulminant hepatic failure secondary to intentional iron overdose

Evaluation of the Effects of N-Acetylcysteine on Serum Glucose, Lipid Profile, and Body weight In rats With Fructose-Induced Metabolic Syndrome

The Acute Effect of Humic Acid on Iron Accumulation in Rats

Contact Info

Product

Resources

About