Intraperitoneal lidocaine hydrochloride for prevention of intraperitoneal adhesions following laparoscopic genitourinary tract surgery in ewes

Mariano, Renata Sitta Gomes; Uscategui, R. A.R.; Nociti, Ricardo Perecin; Santos, Victor José Correia; Padilha-Nakaghi, Luciana Cristina; Barros, Felipe Farias Pereira da Câmara; Silva, M. A.M.; Malta, Caio Afonso dos Santos; Bonato, Denis Vinicius; Vicente, W. R. R.; Teixeira, Pedro Paulo Maia

doi:10.17221/8414-vetmed

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Ovary is prone to adhesions with the abdominal wall, omentum, and adjacent organs because of its close proximity to the abdominal cavity (MARIANO et al, 2015), and this was in the study herein. Although, these authors reported no difficulty with adhesiolysis of the ovary, they reported greater ease of adhesiolysis and possible new oocyte collection after using solutions of NaCl and 1% lidocaine, which are known to reduce adhesion formation.…”

Section: Resultsmentioning

confidence: 79%

Assessment of Laparoscopic Adhesiolysis in the Genitourinary Tract of Ewes

et al. 2022

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Peritoneal adhesions are bridges of fibrous tissue that connect two or more structures, and can cause anatomical and functional changes in organs. Adhesions result from the imbalance between fibrinolysis inhibitors and activators, which are mediated by cytokines. After inflammation, there is an increase in vascular permeability and local fibrin exudation. The aim of this study was to assess adhesiolysis in ewes using laparoscopy after adhesion induction in the uterus, ovary, and adjacent organs using monopolar diathermy. Five ewes were used. For adhesion induction, the ewes underwent laparotomy. A skin incision was performed in the mid-inguinal line, exposing the uterus, ovaries and uterine tubes. The adhesion induction was performed at three points on the right side of the uterus and at three points on the right ovary. Laparoscopic adhesiolysis was performed 15 days after the first surgery. After 30 days, a third procedure was made to evaluate resolution after adhesiolysis. One animal died after the surgery, the necropsy revealed a fistula due to adhesions that resulted in acute peritonitis. Concerning classification, adhesiolysis was impossible in one ewe (25%), partially possible in the reproductive tract, adjacent organs, omentum, and abdominal wall in two ewes (50%), partially possible in reproductive tract in one ewe (25%), and totally possible in none of the ewes. This study shows that monopolar diathermy can induce adhesions. The endo-surgery was only partially effective regarding morbidity, it produced good results as it reduces the occurrence of injuries and promotes clinical improvement by allowing abdominal adhesiolysis. Keywords: Adhesions Treatment. Fibrous Tissue. Laparoscopy. Monopolar Diathermy. Ovary. Resumo As aderências peritoneais são pontes de tecido fibroso que conectam duas ou mais estruturas, podendo causar alterações anatômicas e funcionais em órgãos. As aderências resultam do desequilíbrio entre os inibidores e ativadores da fibrinólise, que são mediados por citocinas. Após a inflamação, ocorre aumento da permeabilidade vascular e exsudação local de fibrina. O objetivo deste estudo foi avaliar a adesiólise em ovelhas por meio de laparoscopia após a indução de aderências no útero, ovário e órgãos adjacentes por meio de diatermia monopolar. Foram utilizadas cinco ovelhas. Para indução de aderências, as ovelhas foram submetidas a laparotomia. Uma incisão na pele foi realizada na linha inguinal média, expondo o útero, ovários e tubas uterinas. A indução da adesão foi realizada em três pontos do lado direito do útero e em três pontos do ovário direito. A adesiólise videolaparoscópica foi realizada 15 dias após a primeira cirurgia. Após 30 dias, um terceiro procedimento foi realizado para avaliar a resolução após adesiólise. Um animal morreu após a cirurgia, a necropsia revelou uma fístula devido a aderências que resultaram em peritonite aguda. Com relação à classificação, adesiólise foi impossível em uma ovelha (25%), parcialmente possível no trato reprodutivo, órgãos adjacentes, omento e parede abdominal em duas ovelhas (50%), parcialmente possível no trato reprodutivo em uma ovelha (25%), e totalmente possível em nenhuma das ovelhas. Nosso estudo mostra que a diatermia monopolar pode induzir aderências. A endocirurgia foi apenas parcialmente eficaz quanto à morbidade, apresentou bons resultados, pois reduz a ocorrência de lesões e promove melhora clínica ao permitir adesiólise abdominal. Palavras-chave: Tratamento de Aderências. Tecido Fibroso. Laparoscopia. Diatermia Monopolar. Ovário.

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Section: Resultsmentioning

confidence: 79%

Assessment of Laparoscopic Adhesiolysis in the Genitourinary Tract of Ewes

et al. 2022

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Efficacy of gelatin sponge in the prevention of post-surgical intra-abdominal adhesion in a rat model

Ibrahim

Kamel

Soliman

2022

Research in Veterinary Science

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Comparison of two surgical approaches for Laparoscopic Ovum Pick Up in Ewes

Mariano

Uscategu

Nociti

et al. 2019

Arq. Bras. Med. Vet. Zootec.

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The present study had as an aim to evaluate a right lateral access as an alternative method to laparoscopic ovum pick-up (LOPU) in sheep. Twenty-four Santa Ines ewes were randomly assigned in two groups with twelve animals each: RLD - positioned in right lateral decubitus, with 10º head-down tilt; and DD - positioned in dorsal decubitus with 35º head-down tilt. The following parameters were evaluated every 10 minutes during the procedure: total surgical time (ST), visualized follicles (VF), aspirated follicles (AF), recovered oocytes (RO), mean arterial pressure (MAP), heart rate (HR), respiratory rate (fR) and end tidal CO2 pressure (EtCO2). Pre and postoperative arterial hemogasometry parameters (PaO2, PaCO2, pH, CHCO3 and BE) were also evaluated; and serum fibrinogen levels (SFL) on postoperative period. The values of VF, AF, RO, fR, PaO2, pH, CHCO3, BE and SFL were similar between groups, although ST, HR, MAP, EtCO2 and PaCO2 were higher in LG. Regarding operative periods, PaO2 and pH were lower after surgery (PaO2: 79.1±16.4; 79.2±11.7mmHg; pH: 7.30±0.09; 7.32±0.08) in both groups when compared to preoperative (PaO2: 80.1±14.3; 83.4±10.5 mmHg; pH: 7.38±0.05; 7.39±0.05) while PaCO2 (43.6±4.6; 41.9±5.4mmHg) and CHCO3 (22.8±1.5; 22.7±3.0mmol/L) increased (PaCO2: 54.3±10.9; 46.9±6.3mmHg; CHCO3: 24.8±3.4; 24.4±2.7mmol/L) postoperative. This alternative decubitus presented is a viable procedure and did not differ in oocyte recovery rates in ewes. However, entails cardiorespiratory major alterations compared to conventional procedure, making its practical applicability limited.

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Intraperitoneal lidocaine hydrochloride for prevention of intraperitoneal adhesions following laparoscopic genitourinary tract surgery in ewes

Cited by 3 publications

References 10 publications

Assessment of Laparoscopic Adhesiolysis in the Genitourinary Tract of Ewes

Assessment of Laparoscopic Adhesiolysis in the Genitourinary Tract of Ewes

Efficacy of gelatin sponge in the prevention of post-surgical intra-abdominal adhesion in a rat model

Comparison of two surgical approaches for Laparoscopic Ovum Pick Up in Ewes

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