Intraperitoneal lignocaine (lidocaine) versus bupivacaine after laparoscopic cholecystectomy: Results of a randomized controlled trial

Khan, Muhammad Rizwan; Raza, Rushna; Zafar, Syed Nabeel; Shamim, Faisal; Raza, Syed Ahsan; Pal, Khawaja Muhammad Inam; Zafar, Hasnain; Alvi, Rehman; Chawla, Tabish; Azmi, Rizwan

doi:10.1016/j.jss.2012.06.005

Cited by 31 publications

(14 citation statements)

References 26 publications

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“…[1] Khan et al, used both lidocaine and bupivacaine intraperitoneally during laparoscopic cholecystectomy for postoperative analgesia and concluded that bupivacaine and lidocaine are both safe and equally effective in decreasing postoperative pain after LC. [15] Some studies evaluated the efficacy of intraperitoneal and intravenous lidocaine on pain relief after LC and they reported significantly reduced postoperative pain and opioid consumption in LC patients, compared with control infusions. [16] Another study evaluated intraperitoneal instillation of 30 ml 0.2% ropivacaine (R group) versus intraperitoneal instillation of 30 ml 0.2% ropivacaine combined with 1 μgr/ kg dexmedetomidine (RD group) and they reported significantly reduced VAS scores in 24 hrs postoperatively, time to first request of analgesia was longest and total analgesic consumption was lowest in RD group compared to R group.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

Toleska

Карталов

Кузмановска

et al. 2018

Prilozi

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Introduction: Patients undergoing laparoscopic cholecystectomy do experience postoperative pain, especially in the abdomen. Postoperative pain management remains a major challenge after laparoscopic procedures. Administration of intraperitoneal local anesthetic (IPLA) after surgery is used as a method of reducing postoperative pain. In this study, we evaluated the effect of intraperitoneal infiltration of local anesthetic (bupivacaine) for pain relief after laparoscopic cholecystectomy. Material and methods: In this prospective, controlled, and randomized study were included 50 patients aged 25-60 years (35 female and 15 male), scheduled to laparoscopic cholecystectomy with ASA classification 1 and 2. Patients were classified randomly into two groups: group A, which included 25 patients who received intraperitoneal instillation of bupivacaine 0.5% 20 ml; and group B, which included 25 patients who didn’t receive any intraperitoneal instillation. Postoperative pain was recorded using the visual analogue scale (VAS) for 24 hours after laparoscopic cholecystectomy. Results: There was no significant difference with respect to age, weight, and sex; duration of surgery; and anesthesia time. VAS scores at different time intervals were statistically significantly lower at all times in group A compared to group B. There were statistically significant differences in VAS scores between group A and group B at all postoperative time points - 1hr,4 hr,8 hr,12hr and 24hr (p < 0.00001). Conclusion: Intraperitoneal instillation of bupivacaine provides good analgesia in the postoperative period after laparoscopic cholecystectomy.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

Toleska

Карталов

Кузмановска

et al. 2018

Prilozi

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“…This may lead to prolonged hospital stay and increased morbidity, which is particularly important in centers performing this operation as a day case procedure ( 1 ). In addition to opioids, several methods have been used for pain relief after laparoscopic cholecystectomy including nonopioid analgesics ( 2 ), intravenous Paracetamol ( 3 ), perioperative parecoxib ( 4 ), administration of intraperitoneal local anesthetics alone ( 5 - 7 ) or in combination with nonopioid analgesics ( 8 , 9 ). This might reduce adverse effects of opioids.…”

Section: Introductionmentioning

confidence: 99%

Comparing the Impact of Intraperitoneal Hydrocortisone With Bupivacaine on Postoperative Pain After Laparoscopic Cholecystectomy

Amini

Sarvestani

2014

Anesth Pain Med

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Background:Postoperative pain is a major complaint following laparoscopic cholecystectomy.Objectives:The aim of this study was to compare the impact of intraperitoneal hydrocortisone with intraperitoneal bupivacaine on pain relief after laparoscopic cholecystectomyPatients and Methods:In a double blind clinical trial, 63 candidates for laparoscopic cholecystectomy were randomly allocated to receive intraperitoneal instillation of either 100 mg bupivacaine in 250 mL normal saline (n = 32) or 100 mg hydrocortisone in 250 mL normal saline (n = 31) before insufflation of CO2 into the peritoneum for postoperative pain relief. Patients were investigated regarding abdominal and shoulder pain using (visual analog scale) VAS in recovery room and at 6, 12 and 24 hours postoperatively. Patients were also followed regarding postoperative analgesic requirements, nausea and vomiting, and return of bowel function.Results:Sixty patients completed the study. Patients in the hydrocortisone group had no statistically significant abdominal and shoulder pain scores compared to the bupivacaine group. The patients were similar regarding postoperative analgesic requirements, return of bowel function, nausea and vomiting. No adverse effect was detected in either group.Conclusions:Intraperitoneal administration of hydrocortisone is as effective as bupivacaine to reduce pain and analgesic requirements after laparoscopic cholecystectomy.

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“…15 Various studies have tested the efficacy of these modalities, as outlined above. But none of the studies have employed combined usage of LA at all 3 sites.…”

Section: Discussionmentioning

confidence: 99%

To assess the role of multisite instillation of bupivacaine-xylocaine combination for reducing post-operative pain after elective laparoscopic cholecystectomy

Gandhi¹,

Shinde²,

Patil³

et al. 2016

Int J Res Med Sci

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Intraperitoneal lignocaine (lidocaine) versus bupivacaine after laparoscopic cholecystectomy: Results of a randomized controlled trial

Cited by 31 publications

References 26 publications

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

Comparing the Impact of Intraperitoneal Hydrocortisone With Bupivacaine on Postoperative Pain After Laparoscopic Cholecystectomy

To assess the role of multisite instillation of bupivacaine-xylocaine combination for reducing post-operative pain after elective laparoscopic cholecystectomy

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