Intrapleural and Intraperitoneal Free Fluid in Calcium Channel Blocker Overdose

Yılmaz, Mustafa; Ay, Mehmet Oğuzhan; Gökel, Yüksel; Kozacı, Nalan; Samanlioglu, Gulnihal; Atli, Mesude; Karakucuk, Seda Nida

doi:10.5152/eajem.2016.91300

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…In the management of patients with CCB poisoning, the use of HIE, ILE treatment, glucagon treatments, as well as treatments including methylene blue and extracorporeal life support should be considered in cases of resistant hypotension, bradycardia and coma in the early period. Studies in the literature are generally case reports (3,7,10,18,21,22). We believe that the data presented regarding these 12 cases will provide an approach for physicians when encountering CCB intoxication.…”

Section: Discussionmentioning

confidence: 97%

“…As a result of the inhibition of these channels, the flow of calcium into the cells is directly inhibited, and the amount of calcium in the cytoplasm decreases. This results in muscle relaxation and arterial dilatation (3,4). Besides, CCBs reduce systemic vascular resistance and almost always present with low blood pressure and resistant shock (5).…”

Section: Introductionmentioning

confidence: 99%

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Our Treatment Experience in Poisoning With Calcium Channel Blockers: A Series of Twelve Cases

Talay,

Orhan,

Ozbek

et al. 2024

Iran J Pediatr

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Background: Intoxications with cardiovascular system drugs constitute a small percentage of all poisoning cases. Calcium Channel Blockers (CCBs) are the most common drug poisoning in this group. Objectives: We aimed to evaluate the effectiveness of treatments for CCB poisoning and add to the current body of literature by outlining the clinical treatments we employ for bradyarrhythmia, hypotension, and resistant vasodilation resulting from CCB poisoning, as well as sharing our clinical insights in this field. Methods: Twelve patients, ranging in age from 1 month to 18 years, were admitted to the Tertiary Paediatric Intensive Care Unit (PICU) for treatment of medication poisoning related to the CCB group. Patients who ingested several drugs that caused CCB were not allowed to participate in the trial. Results: Twelve patients were followed up in the PICU due to poisoning with CCB group drugs. Of the patients, 7 were male and 5 were female. Five of the patients had taken CCB medication with the purpose of committing suicide, and 7 of them accidentally. All of the patients who received CCB to commit suicide had taken verapamil. Five patients whose hypotension and bradycardia continued were administered inotropes. In addition to PI, calcium gluconate, intravenous lipid, glucagon, insulin, bicarbonate, and methylene blue were given as therapy to our symptomatic patients. Plasmapheresis was applied to a patient who was hospitalized in the PICU due to a sudden loss of consciousness. Conclusions: In the management of patients with CCB poisoning, the use of hyperinsulinemia euglycemia, intravenous lipid emulsion treatment, glucagon treatments, and treatments including methylene blue and extracorporeal life support should be considered in cases of resistant hypotension, bradycardia, and coma in the early period.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Our Treatment Experience in Poisoning With Calcium Channel Blockers: A Series of Twelve Cases

Talay,

Orhan,

Ozbek

et al. 2024

Iran J Pediatr

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show abstract

“…However, in this case, pleural effusion could have occurred within the reference dosage range and might not be related to overdose toxification. In previous human cases, CCB‐induced pleural effusion was improved by stopping the medication, and hence it was diagnosed as an adverse drug event of CCB (Kim et al., 2015 , Yılmaz et al., 2016 ). However, pleural effusion or edema caused due to overdosing of amlodipine is rarely improved even when medication is stopped and can be life‐threatening.…”

Section: Discussionmentioning

confidence: 99%

Unusual case of pleural effusion caused by amlodipine in a dog with systemic hypertension

Jang

Park

Hwang

et al. 2022

Veterinary Medicine & Sci

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Objective: The aim of this report is to document the case of a dog that developed pleural effusion as a potential side-effect to the administration of a high-dose of amlodipine. Case summary:A Yorkshire terrier dog (13-year-old, castrated male, 4.5 kg) presented with severe systemic hypertension (>200 mmHg), hyperkalaemia, and acute pancreatitis. The dog had hyperadrenocorticism, chronic valvular heart disease, chronic kidney disease, and cerebellar infarction as underlying diseases. Additionally, the dog had laboured breathing and tachypnoea during hospitalization. Screening examinations revealed a pleural effusion (pure transudate) for which hypoalbuminemia and thromboembolism were ruled out as the causes. Therefore, the adverse drug event of an antihypertensive drug (amlodipine) was tentatively diagnosed. Conclusions:Pleural effusion resolved within 24 h of reducing the dosage of amlodipine. Hence, the dog was diagnosed with amlodipine-induced pleural effusion. Rarely, amlodipine can cause pleural effusion after high-dose administrations in humans, but only two cases of peripheral edema have been reported in animals. If pleural effusion occurs in hypertensive patients administered amlodipine, it should be considered as the potential cause.

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Intrapleural and Intraperitoneal Free Fluid in Calcium Channel Blocker Overdose

Cited by 2 publications

References 13 publications

Our Treatment Experience in Poisoning With Calcium Channel Blockers: A Series of Twelve Cases

Our Treatment Experience in Poisoning With Calcium Channel Blockers: A Series of Twelve Cases

Unusual case of pleural effusion caused by amlodipine in a dog with systemic hypertension

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