Intrapleural Fluid Infusion for MR-Guided High-Intensity Focused Ultrasound Ablation in the Liver Dome

Wijlemans, Joost W.; Greef, Martijn de; Schubert, G.; Moonen, Chrit; Bosch, Maurice A.A.J. van den; Ries, Mario

doi:10.1016/j.acra.2014.06.015

Cited by 11 publications

(11 citation statements)

References 25 publications

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“…Another technique currently under development is "beam-shaping" which excludes the ribs from the beam path thus protecting the patient from uncontrolled heating of the chest wall [42]. For the ablation of lesions in the liver dome, an iatrogenic intrapleural fluid infusion resulting in a pleural effusion could provide the necessary acoustic window [43]. While several studies using ultrasound-guided HIFU for the ablation of liver malignancies exist [44], only few case studies using MR-guided HIFU and demonstrating the feasibility of this approach have been published (▶ Fig.…”

Section: Abdominal Applicationsmentioning

confidence: 99%

Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Overview of Emerging Applications (Part 2)

Siedek

Yeo

Heijman

et al. 2019

Fortschr Röntgenstr

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Background High-intensity focused ultrasound (HIFU) allows noninvasive heating of deep-seated tissues. Guidance under magnetic resonance imaging (MR-HIFU) offers spatial targeting based on anatomical MR images as well as MR-based near-real-time temperature maps. Temperature feedback allows delivery of a well-defined thermal dose enabling new applications such as the ablation of malignant tissue. Methods Peer-reviewed publications on MR-HIFU were studied and are summarized in this review. Literature was restricted to applications in oncology. Results Several MR-HIFU-based applications for the treatment of malignant diseases are currently part of clinical trials or translational research. Recent trials regarding the treatment of prostate cancer with MR-HIFU have already shown this to be a safe and patient-friendly method. For the treatment of breast cancer and malignancies within abdominal organs, MR-HIFU has been applied so far only in proof of concept studies. Conclusion MR-HIFU is currently being investigated for the ablative treatment of malignant tissue in a variety of oncological applications. For example, the transrectal as well as transurethral ablation of prostate cancer using MR-HIFU was shown to be a patient-friendly, safe alternative to other local treatment options with low side effects. Key points: Citation Format

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Section: Abdominal Applicationsmentioning

confidence: 99%

Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Overview of Emerging Applications (Part 2)

Siedek

Yeo

Heijman

et al. 2019

Fortschr Röntgenstr

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“…Distances to these critical structures were evaluated herein but not used as exclusion criteria. While MR-HIFU is challenged by respiratory and cardiac motion [25,26], these factors were not evaluated or used as exclusion criteria in this study.…”

Section: Targetabilitymentioning

confidence: 99%

“…The use of MR-safe temperature probes for direct temperature monitoring and/or the use of an acoustic conduit such as acoustic gel, cold water bags or gel pads, combined with frequent monitoring of at-risk sites may help reduce off-target tissue heating and prevent injury [52]. Creative strategies such as inducing a hydrothorax to avoid lung injury when treating a body wall mass with MR-HIFU have been utilised in human patients [26].…”

Section: Treatment Planningmentioning

confidence: 99%

Feasibility of targeting canine soft tissue sarcoma with MR-guided high-intensity focused ultrasound

Seward

Daniel

Ruth

et al. 2018

International Journal of Hyperthermia

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Purpose: Magnetic resonance imaging-guided high-intensity-focused ultrasound (MR-HIFU) is a noninvasive treatment modality that precisely focuses ultrasound energy within a tumour and can be customised to result in a wide range of local bioeffects. The purpose of this study was to determine the feasibility of using MR-HIFU to treat soft tissue sarcoma (STS) in dogs. Materials and methods: Medical records of dogs admitted to the Virginia-Maryland College of Veterinary Medicine from 1 January 2012 to 31 December 2016 were searched for a diagnosis of sarcoma with available cross-sectional imaging of the tumour (MRI or CT). Fifty-three (53) dogs were eligible for inclusion. Tumor tissue (in bone as well as in soft tissue) was considered targetable unless: (1) the ultrasound path was completely obstructed by bone or gas and (2) the MR-HIFU target was within the spinal cord or less than 1 cm from the margin of the spinal cord. Tumors were categorised as <50% targetable, !50% targetable or non-targetable. Results: Eighty-one percent of STS (81.1%, 43/53) were targetable. The head/spine tumour sites had the highest proportion of non-targetable tumours (36%, 9/25). The majority of truncal and axillary tumours were !50% targetable (88.9%, 16/18) ,and all extremity tumours were considered !50% targetable (100%, 5/5). Conclusions: The majority of STS were targetable. This is the first study to evaluate MR-HIFU targetability of canine STS. HIFU has potential as a therapeutic modality for treating STS in dogs, and this veterinary application is a possible model for treatment of naturally occurring STS in humans.

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“…42 Portable high-intensity FUS devices were tested for several other applications in other tissues, including non-invasive venous ablation, 43 reduction of subcutaneous adipose tissue and non-invasive body sculpting. 44 (c) An analysis of factors affecting clinical success of MRgFUS should be performed.…”

Section: Mrgfus Lessons Learned From Non-musculoskeletal Applicationsmentioning

confidence: 99%

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

Bazzocchi¹,

Napoli²,

Sacconi³

et al. 2016

BJR

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MRI-guided focused ultrasound surgery (MRgFUS) is a minimally invasive treatment guided by the most sophisticated imaging tool available in today's clinical practice. Both the imaging and therapeutic sides of the equipment are based on non-ionizing energy. This technique is a very promising option as potential treatment for several pathologies, including musculoskeletal (MSK) disorders. Apart from clinical applications, MRgFUS technology is the result of long, heavy and cumulative efforts exploring the effects of ultrasound on biological tissues and function, the generation of focused ultrasound and treatment monitoring by MRI. The aim of this article is to give an updated overview on a "new" interventional technique and on its applications for MSK and allied sciences

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Intrapleural Fluid Infusion for MR-Guided High-Intensity Focused Ultrasound Ablation in the Liver Dome

Cited by 11 publications

References 25 publications

Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Overview of Emerging Applications (Part 2)

Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Overview of Emerging Applications (Part 2)

Feasibility of targeting canine soft tissue sarcoma with MR-guided high-intensity focused ultrasound

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

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