Intrapulmonary Lymph Nodes: Thin-Section CT Features of 19 Nodules

Oshiro, Yoshinori; Kusumoto, Masahiko; Moriyama, Noriyuki; Kaneko, Masahiro; Suzuki, Koichi; Asamura, Hisao; Kondo, Haruhiko; Tsuchiya, R; Murayama, Sadayuki

doi:10.1097/00004728-200207000-00014

Cited by 50 publications

(22 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we identified, to our knowledge, two new independent negative predictive factors for malignancy in indeterminate solid NCNs detected in a population at high risk for lung cancer (21,22). The juxtavascular nodules may represent small lymph nodes or small branching vessels, while bronchiolitis or a small bronchiectasis may also appear as a vessel-or fissure-attached nodule.…”

Section: Discussionmentioning

confidence: 80%

Smooth or Attached Solid Indeterminate Nodules Detected at Baseline CT Screening in the NELSON Study: Cancer Risk during 1 Year of Follow-up

Xu¹,

Zaag-Loonen²,

Oudkerk³

et al. 2009

Radiology

137

110

View full text Add to dashboard Cite

Purpose:To retrospectively determine whether baseline nodule characteristics at 3-month and 1-year volume doubling time (VDT) are predictive for lung cancer in solid indeterminate noncalcified nodules (NCNs) detected at baseline computed tomographic (CT) screening. Materials and Methods:The study, conducted between April 2004 and May 2006, was institutional review board approved. Patient consent was waived for this retrospective evaluation. NCNs between 5 and 10 mm in diameter (n ϭ 891) were evaluated at 3 months and 1 year to assess growth (VDT Ͻ 400 days). Baseline assessments were related to growth at 3 months and 1 year by using 2 and Mann-Whitney U tests. Baseline assessments and growth were related to the presence of malignancy by using univariate and multivariate logistic regression analyses. Results:At 3 months and at 1 year, 8% and 1% of NCNs had grown, of which 15% and 50% were malignant, respectively. One-year growth was related to morphology (P Ͻ .01), margin (P Ͻ .0001), location (P Ͻ .001), and size (P Ͻ .01). All cancers were nonspherical and purely intraparenchymal, without attachment to vessels, the pleura, or fissures. In nonsmooth unattached nodules, a volume of 130 mm 3 or larger was the only predictor for malignancy (odds ratio, 6.3; 95% confidence interval [CI]: 1.7, 23.0). After the addition of information on the 3-month VDT, large volume (odds ratio, 4.9; 95% CI: 1.2, 20.1) and 3-month VDT (odds ratio, 15.6; 95% CI: 4.5, 53.5) helped predict malignancy. At 1 year, only the 1-year growth remained (odds ratio, 213.3; 95% CI: 18.7, 2430.9) as predictor for malignancy. Conclusion:In smooth or attached solid indeterminate NCNs, no malignancies were found at 1-year follow-up. In nonsmooth purely intraparenchymal NCNs, size is the main baseline predictor for malignancy. When follow-up data are available, growth is a strong predictor for malignancy, especially at 1-year follow-up. RSNA, 2008

show abstract

Section: Discussionmentioning

confidence: 80%

Smooth or Attached Solid Indeterminate Nodules Detected at Baseline CT Screening in the NELSON Study: Cancer Risk during 1 Year of Follow-up

Xu¹,

Zaag-Loonen²,

Oudkerk³

et al. 2009

Radiology

137

110

View full text Add to dashboard Cite

show abstract

“…Nine subjects had died at the time of long-term follow-up. ( 24,25,27 ). In one study ( 27 ), 10 (53%) of 19 intrapulmonary lymph nodes were adjacent to the visceral pleura, with the remaining nine located 2-8 mm from the pleura.…”

Section: Discussionmentioning

confidence: 96%

Perifissural Nodules Seen at CT Screening for Lung Cancer

Ahn¹,

Gleeson²,

Chan³

et al. 2010

Radiology

141

View full text Add to dashboard Cite

show abstract

“…Since there was no pathological material available from these benign nodules it can only be speculated what the underlying cause might be, including the spontaneous resolution of infectious lesions or local mucus impaction. Lymph nodes are less likely to be involved since the indeterminate nodules selected were situated within the lung parenchyma, while lymph nodes usually are located in the close vicinity of the broncho-vascular tree, the subpleural area or area attached to fissures [26,27].…”

Section: Discussionmentioning

confidence: 99%

Role of baseline nodule density and changes in density and nodule features in the discrimination between benign and malignant solid indeterminate pulmonary nodules

Klaveren

Bock

et al. 2009

European Journal of Radiology

View full text Add to dashboard Cite

Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractPurpose: To retrospectively evaluate whether baseline nodule density or changes in density or nodule features could be used to discriminate between benign and malignant solid indeterminate nodules. Materials and methods: Solid indeterminate nodules between 50 and 500 mm 3 (4.6-9.8 mm) were assessed at 3 and 12 months after baseline lung cancer screening (NELSON study). Nodules were classified based on morphology (spherical or non-spherical), shape (round, polygonal or irregular) and margin (smooth, lobulated, spiculated or irregular). The mean CT density of the nodule was automatically generated in Hounsfield units (HU) by the Lungcare © software. Results: From April 2004 to July 2006, 7310 participants underwent baseline screening. In 312 participants 372 solid purely intra-parenchymal nodules were found. Of them, 16 (4%) were malignant. Benign nodules were 82.8 mm 3 (5.4 mm) and malignant nodules 274.5 mm 3 (8.1 mm) (p = 0.000). Baseline CT density for benign nodules was 42.7 HU and for malignant nodules −2.2 HU (p = ns). The median change in density for benign nodules was −0.1 HU and for malignant nodules 12.8 HU (p < 0.05). Compared to benign nodules, malignant nodules were more often non-spherical, irregular, lobulated or spiculated at baseline, 3-month and 1-year follow-up (p < 0.0001). In the majority of the benign and malignant nodules there was no change in morphology, shape and margin during 1 year of follow-up (p = ns). Conclusion: Baseline nodule density and changes in nodule features cannot be used to discriminate between benign and malignant solid indeterminate pulmonary nodules, but an increase in density is suggestive for malignancy and requires a shorter follow-up or a biopsy.

show abstract

Intrapulmonary Lymph Nodes: Thin-Section CT Features of 19 Nodules

Cited by 50 publications

References 14 publications

Smooth or Attached Solid Indeterminate Nodules Detected at Baseline CT Screening in the NELSON Study: Cancer Risk during 1 Year of Follow-up

Smooth or Attached Solid Indeterminate Nodules Detected at Baseline CT Screening in the NELSON Study: Cancer Risk during 1 Year of Follow-up

Perifissural Nodules Seen at CT Screening for Lung Cancer

Role of baseline nodule density and changes in density and nodule features in the discrimination between benign and malignant solid indeterminate pulmonary nodules

Contact Info

Product

Resources

About