Intrapulmonary penetration of linezolid

Honeybourne, D.; Tobin, C. M.; Jevons, G.; Andrews, J. M.; Wise, R.

doi:10.1093/jac/dkg262

Cited by 121 publications

(42 citation statements)

References 9 publications

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“…Linezolid MIC values (range, 0.12-0.5 mg/L) of the tested strains were well below linezolid concentrations that can be attained in serum (13.4 mg/L), alveolar macrophages (8.1 mg/L) and epithelial lining fluid (25.1 mg/L) using standard doses [13][14][15].…”

Section: Susceptibility Of M Tuberculosis and Pharmacokinetic Valuesmentioning

confidence: 75%

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In vitro activity of linezolid against Mycobacterium tuberculosis complex, including multidrug-resistant Mycobacterium bovis isolates

Tato

Pedrosa

Cantón

et al. 2006

International Journal of Antimicrobial Agents

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Section: Susceptibility Of M Tuberculosis and Pharmacokinetic Valuesmentioning

confidence: 75%

“…Results obtained using two different methods, the standard agar proportion method in 7H10 medium and the ESP Culture System II, were compared [11,12]. Susceptibility test results were compared with previously published linezolid pharmacokinetic data [13][14][15]. …”

Section: Introductionmentioning

confidence: 99%

In vitro activity of linezolid against Mycobacterium tuberculosis complex, including multidrug-resistant Mycobacterium bovis isolates

Tato

Pedrosa

Cantón

et al. 2006

International Journal of Antimicrobial Agents

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“…Additional population-based studies are needed to determine whether a difference truly exists. However, there are theoretical reasons to believe that agents such as linezolid or clindamycin may have an additional benefit because they are associated with less toxin release [106] and attain good concentrations in the lung parenchyma [107,108]. Both clindamycin and linezolid markedly suppress PVL production as staphylococci approach the stationary phase, and there may be no PVL detectable 12 h after starting treatment [109].…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with the Outcome of Life-Threatening Necrotizing Pneumonia due to Community-Acquired <i>Staphylococcus aureus</i> in Adult and Adolescent Patients

Zhang²,

Huang³

et al. 2010

Respiration

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Background: Although community-acquired Staphylococcus aureus pneumonia with highly virulent Panton-Valentine leukocidin (PVL)-positive strains, a severe disease with significant lethality, is rare, especially in adult and adolescent patients, recent reports highlight that these infections are on the rise. Objectives: To describe the demographic and clinical features of reported cases of life-threatening community-acquired S. aureus pneumonia with usually PVL-positive strains in adult and adolescent patients, to evaluate the variables related to death, and to select a more appropriate antimicrobial treatment for this potentially deadly disease. Methods: We summarized all of the 92 reported cases and our case. The effect of 5 variables on mortality was measured using logistic regression. Results:S. aureus community-acquired pneumonia (CAP) with usually PVL-positive strains is a severe disease with significant lethality, i.e. 42.9%; a short duration of the time from the onset of symptoms to death, i.e. 5.5 ± 10.1 days, and prolonged hospital admissions, i.e. 33.2 ± 29.5 days. Seventy-three cases have been tested for the gene for PVL, and 71 strains have been found to carry the PVL gene. Logistic regression analysis showed that leucopenia (p = 0.002), influenza-like symptoms or laboratory-confirmed influenza (p = 0.011), and hemoptysis (p = 0.024) were the factors associated with death. Antibiotic therapies inhibiting toxin production were associated with an improved outcome in these cases (p = 0.007). Conclusions: Physicians should pay special attention to those patients who acquired severe CAP during influenza season and have flu-like symptoms, hemoptysis, and leucopenia, and they should consider S. aureus more frequently among the possible pathogens of severe CAP. Empiric therapy for severe CAP with this distinct clinical picture should include coverage for S. aureus. Targeted treatment with antimicrobials inhibiting toxin production appears to be a more appropriate selection.

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“…However, recently a surge has been seen in the number of invasive diseases caused by CA-MRSA such as septic arthritis, septic shock, osteomyelitis, and pneumonia [11,14]. Panton-Valentine leukocidin (PVL) has been blamed for the invasive capability of CA-MRSA resulting in severe pneumonia, including necrotizing pneumonia.…”

Section: Invasivenessmentioning

confidence: 99%

Methicillin-resistant Staphylococcus aureus as a cause of community-acquired pneumonia

Stankovic

Mahajan²,

Asmar³

2007

Curr Infect Dis Rep

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New pathogens have emerged that now complicate the management of community-acquired pneumonia (CAP). Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as a potential cause of CAP, particularly complicated CAP. In this literature review, the incidence, invasiveness, and antimicrobial management of CA-MRSA is discussed. Based on existing data and the rising incidence of CA-MRSA, we recommend a change in antibiotic selection for complicated CAP.

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Intrapulmonary penetration of linezolid

Abstract: The MIC90 (< or =4 mg/L) of linezolid for Staphylococcus aureus and Streptococcus pneumoniae was exceeded in serum and bronchial mucosa in all subjects, in epithelial lining fluid in nine subjects and in macrophages in six subjects.

Cited by 121 publications

References 9 publications

In vitro activity of linezolid against Mycobacterium tuberculosis complex, including multidrug-resistant Mycobacterium bovis isolates

In vitro activity of linezolid against Mycobacterium tuberculosis complex, including multidrug-resistant Mycobacterium bovis isolates

Factors Associated with the Outcome of Life-Threatening Necrotizing Pneumonia due to Community-Acquired <i>Staphylococcus aureus</i> in Adult and Adolescent Patients

Methicillin-resistant Staphylococcus aureus as a cause of community-acquired pneumonia

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