2022
DOI: 10.3390/antiox11091702
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Intrarenal Arterial Transplantation of Dexmedetomidine Preconditioning Adipose Stem-Cell-Derived Microvesicles Confers Further Therapeutic Potential to Attenuate Renal Ischemia/Reperfusion Injury through miR-122-5p/Erythropoietin/Apoptosis Axis

Abstract: Intravenous adipose mesenchymal stem cells (ADSCs) attenuate renal ischemia/reperfusion (IR) injury but with major drawbacks, including the lack of a specific homing effect after systemic infusion, cell trapping in the lung, and early cell death in the damaged microenvironment. We examined whether intrarenal arterial transplantation of dexmedetomidine (DEX) preconditioning ADSC-derived microvesicles (DEX-MVs) could promote further therapeutic potential to reduce renal IR injury. We evaluated the effect of DEX-… Show more

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Cited by 5 publications
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“…Various combinations of effects are known, for example, when a chemical effect is manifested by a physical one or vice versa. The preconditioning effect is known at the level of the organism [88,89], physiology [90,91], tissues [8,92], cells [93], and biological residues, liquids, aqueous colloids, and solutions [94,95], and, as shown in this study, in water.…”
Section: Influence Of Magnetic Field and Mechanical Action By Pipetti...mentioning
confidence: 94%
“…Various combinations of effects are known, for example, when a chemical effect is manifested by a physical one or vice versa. The preconditioning effect is known at the level of the organism [88,89], physiology [90,91], tissues [8,92], cells [93], and biological residues, liquids, aqueous colloids, and solutions [94,95], and, as shown in this study, in water.…”
Section: Influence Of Magnetic Field and Mechanical Action By Pipetti...mentioning
confidence: 94%