2001
DOI: 10.1159/000054224
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Intrarenal Distribution of Blood Flow in Sodium Depleted and Sodium Loaded Rats: Role of Nitric Oxide

Abstract: The renal hemodynamic effects of nitric oxide synthase (NOS) inhibition and dietary salt were studied in rats. L-NAME (0.1 mg/ml in the drinking fluid, about 12 mg/kg/day) was given for 4 days to rats receiving low (sodium depletion, SD), normal (N) or high (sodium load, SL) NaCl diet. Intrarenal hemodynamics was studied in anaesthesia. NOS inhibition decreased renal blood flow and increased renal vascular resistance in each group. Cortical and outer medullary but not inner medullary blood flow increased in di… Show more

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Cited by 4 publications
(3 citation statements)
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“…which might result in higher shear stiffness as predicted by a microchannel flow model (35). Conversely, a higher fluid volume caused by expandable vessels, lower hydrostatic pressure, selective medullary control, and fluid balance between fluid compartments after water intake could contribute to the observed decrease in medullary stiffness (36,37). Aging was also found to have only a minor influence on renal MRE.…”
Section: Physiological Effects On Renal Stiffnessmentioning
confidence: 94%
“…which might result in higher shear stiffness as predicted by a microchannel flow model (35). Conversely, a higher fluid volume caused by expandable vessels, lower hydrostatic pressure, selective medullary control, and fluid balance between fluid compartments after water intake could contribute to the observed decrease in medullary stiffness (36,37). Aging was also found to have only a minor influence on renal MRE.…”
Section: Physiological Effects On Renal Stiffnessmentioning
confidence: 94%
“…Furthermore, nitric oxide and superoxide also affect tubular oxygen consumption through the ability of nitric oxide to inhibit oxygen utilization by the mitochondria (11). They also strongly influence vascular tone in both the cortical and medullary circulations (45,61,168). There is evidence that metabolites of arachidonic acid can diffuse from venules to adjacent arterioles in skeletal muscle to induce vasodilatation, providing a local feedback mechanism through which tissue perfusion can be regulated to match metabolic demand (63,64).…”
Section: R804 Diffusive Shunting In the Renal Vasculaturementioning
confidence: 99%
“…L-NAME in the drinking fluid given to rats for 4 days decreased renal blood flow and increased renal vascular resistance (Hably et al, 2001). In spontaneously hypertensive rats, afferent glomerular arteriolar constriction by L-NAME was greater than that of efferent arterioles (Ono et al, 1995).…”
Section: Renal Vasculaturementioning
confidence: 99%