Intrarenal Vascular Resistance is Associated With a Prothrombotic State in Hypertensive Patients

Catena, Cristiana; Colussi, GianLuca; Novello, Marileda; Fagotto, Valentina; Sechi, Leonardo A.

doi:10.1159/000452594

Cited by 9 publications

(7 citation statements)

References 31 publications

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“…Therefore, an investigation of changes in PTS might have both practical significance and clinical value. A previous study found that a combined increase in fibrinogen and D‐dimer levels might indicate the existence of PTS. Because blood viscosity was found to be significantly increased in a group of patients with small artery occlusion, and ADP‐induced platelet aggregation function is a predictive factor of poor coronary events, these indices were included among the present items for comprehensive screening of PTS.…”

Section: Discussionmentioning

confidence: 96%

Endometrial receptivity and conception outcome among women with light menstrual bleeding of unidentified etiology

Gao

Hong

Wang

et al. 2017

Intl J Gynecology & Obste

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Objective: To investigate endometrial receptivity (ER), conception outcome, and other factors among women with light menstrual bleeding of unidentified etiology. Methods:A prospective study was undertaken at a center in China. Between January 1, 2011, and December 31, 2014, women meeting the inclusion criteria (aged 20-35 years, without any history of pregnancy, desire to conceive, follicle-stimulating hormone <10 IU on second or third day of cycle, and regular menstrual periods) were enrolled. Participants with a menstrual blood volume of 5-20 mL formed the study group; others were in the control group. ER measures were obtained by transvaginal Doppler ultrasonography. Serum estradiol and progesterone levels were measured and items of prethrombotic state were screened in mid-luteal phase. Participants were followed up for 1 year to establish conception outcome. Results:The ER (Salle) score was significantly lower in the study group (n=110) than in the control group (n=330; 9.41 ± 3.02 vs 15.67 ± 2.63, P<0.001). The natural rate of conception within 1 year was lower (60.0% [63/105] Conclusion:Women with light menstrual bleeding of unidentified etiology had an increased prevalence of low ER and poor conception outcome. K E Y W O R D S

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Section: Discussionmentioning

confidence: 96%

Endometrial receptivity and conception outcome among women with light menstrual bleeding of unidentified etiology

Gao

Hong

Wang

et al. 2017

Intl J Gynecology & Obste

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“…In several studies, increased intrarenal RI is directly correlated to cardiovascular risk, systemic atherosclerosis, and mortality. For example, in essential hypertensive patients with GFR higher than 30 mL/min/1.73 m 2 , Catena et al showed that intrarenal RI is associated with a pro-thrombotic state [ 30 ], while Pontremoli et al observed an independent correlation between intrarenal RI, carotid intima-media thickness, and left ventricular hypertrophy [ 15 ]. In addition, Watanabe et al observed that intrarenal RI is associated with multi-site atherosclerosis assessed by the coronary artery calcium score and the carotid intima-media thickness in patients with preserved renal function and these associations are independent of hypertension [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated Intrarenal Resistive Index Predicted Faster Renal Function Decline and Long-Term Mortality in Non-Proteinuric Chronic Kidney Disease

Romano

Mioni

Danieli

et al. 2022

JCM

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Background. Intrarenal resistive index (RI) ≥ 0.80 predicts renal outcomes in proteinuric chronic kidney disease (CKD). However, this evidence in non-proteinuric patients with CKD of unknown etiology is lacking. In this study, we assessed the effect of intrarenal RI on renal function and all-cause mortality in non-proteinuric patients with CKD of unknown etiology despite an extensive diagnostic work-up. Methods. Non-proteinuric CKD patients were evaluated in a retrospective longitudinal study. Progression of renal disease was investigated by checking serum creatinine levels at 1, 3, and 5 years and defined by a creatinine level increase of at least 0.5 mg/dL. The discrimination performance of intrarenal RI in predicting the 5-year progression of renal disease was assessed by calculating the area under the receiver operating characteristic curve (AUROC). Results. One-hundred-thirty-one patients (76 ± 9 years, 56% males) were included. The median follow-up was 7.5 years (interquartile range 4.3–10.5) with a cumulative mortality of 53%, and 5-year renal disease progression occurred in 25%. Patients with intrarenal RI ≥ 0.80 had a faster increase of serum creatinine levels compared to those with RI < 0.80 (+0.06 mg/dL each year, 95% CI 0.02–0.10, p < 0.010). Each 0.1-unit increment of intrarenal RI was an independent determinant of 5-year renal disease progression (odds ratio 4.13, 95% CI 1.45–12.9, p = 0.010) and predictor of mortality (hazards ratio 1.80, 95% CI 1.05–3.09, p = 0.034). AUROCs of intrarenal RI for predicting 5-year renal disease progression and mortality were 0.66 (95% CI 0.57–0.76) and 0.67 (95% CI 0.58–0.74), respectively. Conclusions. In non-proteinuric patients with CKD of unknown etiology, increased intrarenal RI predicted both a faster decline in renal function and higher long-term mortality, but as a single marker, it showed poor discrimination performance.

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“…To investigate the cause of resistant hypertension, all patients seen at the clinic are routinely screened with clinical and laboratory testing that include analysis of medical records and adherence to treatment, physical examination, urine analysis, blood biochemistries, duplicate measurements of 24-hour creatinine clearance and urinary sodium excretion, plasma active renin and aldosterone, urinary cortisol and catecholamines, electrocardiogram, echocardiography, polysomnography, renal ultrasound with duplex Doppler examination of intrarenal vessels, and renal angio-CT scan or angio-MRI [14]. Renal angiography was performed in all patients in whom increased intrarenal duplex systolic velocity was detected and/or renal artery stenosis was demonstrated either at angio-MRI or angio-CT scan [15]. Patients were classified as smokers if they had smoked for at least 5 years, and up to 1 year before the study.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Renal and Cardiac Outcomes after Stenting in Patients with Resistant Hypertension and Atherosclerotic Renal Artery Stenosis

Catena

Colussi

Brosolo

et al. 2017

Kidney Blood Press Res

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Background/Aims: Atherosclerotic renal artery stenosis (ARAS) is frequently detected in patients with resistant hypertension (RHTN), but the evidence supporting the utility of renal revascularization in these patients is limited. This prospective, observational study investigates the outcomes of renal stenting in patients with RHTN and hemodynamically significant ARAS. Methods: Fifty-four patients with RHTN were selected because of angiographic evidence of ARAS >70% and were followed for 4 years after renal stenting. Renal function and echocardiographic variables were assessed at baseline and during follow-up. Results: Blood pressure decreased rapidly after renal stenting and was normalized in 67% of patients at six months, with significant reduction in the number of antihypertensive drugs. Creatinine clearance increased in 39% of patients, decreased in 52%, and remained stable in the remaining 9%, with an average value that had a nonsignificant decrease during follow-up. Urinary albumin excretion did not change throughout the study. After 4 years, left ventricular (LV) wall thickness and concentric geometry decreased significantly and variables of LV diastolic function improved. Conclusion: In patients with RHTN, stenting of hemodynamically significant ARAS decreases blood pressure, preserves renal function in a substantial proportion of patients, and improves LV structure and function, suggesting the opportunity for timely identification of ARAS in these patients.

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Intrarenal Vascular Resistance is Associated With a Prothrombotic State in Hypertensive Patients

Cited by 9 publications

References 31 publications

Endometrial receptivity and conception outcome among women with light menstrual bleeding of unidentified etiology

Endometrial receptivity and conception outcome among women with light menstrual bleeding of unidentified etiology

Elevated Intrarenal Resistive Index Predicted Faster Renal Function Decline and Long-Term Mortality in Non-Proteinuric Chronic Kidney Disease

Long-Term Renal and Cardiac Outcomes after Stenting in Patients with Resistant Hypertension and Atherosclerotic Renal Artery Stenosis

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