Intrasaccular Flow-Disruption Treatment of Intracranial Aneurysms: Preliminary Results of a Multicenter Clinical Study

Abstract

BACKGROUND AND PURPOSE:The endovascular treatment of intracranial aneurysms with unfavorable anatomy (large aneurysms, wide-neck) is frequently challenging and is also associated with a high incidence of significant recurrences. The WEB, an intrasaccular flow disrupter, was designed for use in this type of aneurysm. We report our early experience with this device in this multicenter study.

WEB Treatment of Intracranial Aneurysms: Clinical and Anatomic Results in the French Observatory

“…[10][11][12][13][14][15][16][17] The rate of thromboembolic events with the WEB (14.5%) was quite similar to that reported in the Analysis of Treatment by Endovascular Approach of Nonruptured Aneurysms (ATENA) and Clinical and Anatomical Results In the Treatment of Ruptured Intracranial Aneurysms (CLARITY) series (respectively, 7.3% and 13.3%).…”

“…Treatment with the WEB has been evaluated in several retrospective series showing good safety results. [10][11][12][13] In addition, midterm and long-term anatomic results have been evaluated in retrospective series showing good stability of the treatment. 14,15 To have a more rigorous evaluation of the safety and efficacy, 2 prospective, Good Clinical Practice series were initiated simultaneously in Europe (WEB Clinical Assessment of IntraSaccular Aneurysm Therapy [WEBCAST]) and in France (French Observatory).…”

Intrasaccular Flow Disruption in Acutely Ruptured Aneurysms: A Multicenter Retrospective Review of the Use of the WEB

“…In nonruptured aneurysms, the WEB has been described in a number of published series to be both safe and efficacious. [12][13][14] Because of its conceptual difference from standard coil occlusion, a potential yet unproven advantage of the WEB is faster hemodynamic separation of the aneurysm; immediate stasis is often seen after its deployment (Fig 2). The absence of overlapping radiopaque material might enable accurate positioning at the level of the neck, even in broad-based aneurysms.…”

“…12 Numerous publications have described the successful use of the WEB in the treatment of unruptured wide-neck bifurcation aneurysms. [12][13][14] Just recently, a single-center experience with the WEB in 6 ruptured aneurysms was reported, and the results were promising. 15 In this retrospective multicenter case series, we describe use of the WEB in 52 aneurysms in 47 patients who presented with subarachnoid hemorrhage secondary to a ruptured intracranial aneurysm.…”

WEB Treatment of Intracranial Aneurysms: Feasibility, Complications, and 1-Month Safety Results with the WEB DL and WEB SL/SLS in the French Observatory

“…The initial clinical results have shown that treatment is feasible with a low level of complications, low morbidity, and no mortality. [10][11][12][13][14] The device has been progres- The French Observatory is a prospective, multicenter observational study of consecutive cases, with independent monitoring, across 10 French centers.…”