Intrascrotal injection of botulinum toxin A, a male genital aesthetic demand: Technique and limits

Ramelli, E; Brault, N.; Tierny, Chloe; Atlan, Michaël; Cristofari, S.

doi:10.1016/j.purol.2020.04.016

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Scrotox refers to a non-surgical cosmetic treatment of the scrotum with Botox injections. Scrotox involves having Botox injected into the testicles, more specifically injected into the cremaster muscle and Dartos muscles ( 30 , 31 ). This treatment can reduce the sweating, reduce the wrinkles, and make the scrotum appear larger by relaxing the muscles, hence enhance the cosmetic appearance.…”

Section: Scrotoxmentioning

confidence: 99%

Cosmetic male genital surgery: a narrative review

Danino,

Trouilloud,

Benkhadra

et al. 2024

Ann Transl Med

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Background and Objective Through the centuries the appearance of the male genitalia has always been an important concern for men, symbolizing virility, potency and sexual contentment. Correction of perceived deficiencies and deformities of the male genitalia can be addressed by aesthetic surgery as well as the enhancement its external aspect. If the social acceptance of cosmetic surgery, particularly of women’s breasts, dates from the early 1950s, male intimate cosmetic surgery emerged from the shadows about 10 years ago with a medical community still very suspicious and reproachful. The present paper aims to describe and discuss the current state of the art regarding male intimate cosmetic surgery. Methods A narrative review of the literature was performed using publications from January 2000 to September 2022. The publications were retrieved from the PubMed database using Medical Subject Headings (MeSH) terms and keywords. The authors’ goal is to narrate the aesthetic non-surgical and surgical enhancement procedures of the male apparatus. Key Content and Findings This narrative review examines the diverse procedures associated with male genitalia aesthetics. Conclusions Aesthetics of the male genitalia is now an unavoidable and important part of aesthetic surgery worldwide with an increasing demand. Nonsurgical and surgical techniques described in the literature should be reviewed.

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Section: Scrotoxmentioning

confidence: 99%

Cosmetic male genital surgery: a narrative review

Danino,

Trouilloud,

Benkhadra

et al. 2024

Ann Transl Med

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“…While a trace amount of purified BoNT has been identified to yield long-lasting anti-ageing therapeutic benefits and mitigating neuromuscular defects in various illnesses [ 8 , 9 , 11 ], some toxicological reports indicated that cremasteric injection of BoNT (10–40 U/kg) induces cell death and impairs spermiogenesis in the testis of experimental animals [ 12 , 13 ]. However, a recent report revealed that intrascrotal injection of BoNT in adult men did not induce any obvious adverse effect [ 14 ]. Nevertheless, ample scientific evidence unequivocally points towards the positive episodes of a mild dose of BoNT against various clinical complications including movement disorders, cognitive deficits and behavioural abnormalities [ 8 , 9 , 11 , 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

et al. 2022

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Background Botulinum toxin (BoNT) is a widely used therapeutic agent that blocks the excessive release of acetylcholine at the neuromuscular junction. Previously, repeated intracremasteric injections and slight overdose of BoNT have been reported to induce adverse effects in the testicular parameter of experimental rodents. However, a mild dose of BoNT is highly beneficial against skin ageing, neuromuscular deficits, overactive urinary bladder problems, testicular pain and erectile dysfunctions. Considering the facts, the possible therapeutic benefits of BoNT on the testis might be achieved at a very minimal dosage and via a distal route of action. Therefore, we revisited the effect of BoNT, but with a trace amount injected into the vastus lateralis of the thigh muscle, and analyzed histological parameters of the testis, levels of key antioxidants and sperm parameters in ageing experimental mice. Results Experimental animals injected with 1 U/kg bodyweight of BoNT showed enhanced spermatogenesis in association with increased activities of key antioxidants in the testis, leading to enhanced amount of the total sperm count and progressive motility. Conclusions This study signifies that a mild intramuscular dose of BoNT can be considered as a potent treatment strategy to manage and prevent male infertility.

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“…However, few toxicological reports indicated that cremasteric injection of botulinum toxin (10, to 40 U/kg) induces cell death and impairs spermiogenesis in the testis of experimental animals [12,13], while a recent report indicates that intrascrotal injection of botulinum toxin in adult male did not induce any adverse effect [14]. Nevertheless, ample scientific evidence unequivocally points towards the positive episodes of a very mild dose of therapeutic botulinum toxin such as BOTOX® against various clinical complications including movement disorders, cognitive deficit and behavioral abnormalities [8,9,11,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Single injection of very mild dose BOTOX in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

Radhakrishnan

Ravichandran

Sukesh

et al. 2021

Preprint

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Acetylcholine (ACh), a key neurochemical messenger that plays key roles in neuroplasticity and muscle contraction. While ACh is important for the physiological function of the testis, abnormal levels of ACh cause testicular atrophy and male infertility. BOTOX is a therapeutic form of the botulinum neurotoxin that blocks the excessive release of ACh at the neuromuscular junction. Previously, repeated intracremasteric injections and slight overdose of BOTOX have been reported to induce adverse effects in the testicular parameter of experimental rodents. However, a mild dose of BOTOX is highly beneficial against skin ageing, neurological deficits, overactive urinary bladder problems, testicular pain and erectile dysfunctions. Considering the facts, the possible therapeutic benefit of BOTOX on the testis might be achieved via its minimal dose and indirect mode of action rather than repeated high quantity in the local supply. Therefore, we revisited the effect of BOTOX but with a trace amount injected into the vastus lateralis of the thigh muscle, and analyzed histological parameters of testis and quality of semen in ageing experimental mice. Experimental animals injected with 1 U/kg bodyweight of BOTOX showed enhanced spermatogenesis in associations with increased activities of key antioxidants in the testis, leading to increased total sperm count and motility. This study signifies that a mild intramuscular dose of BOTOX can be considered as a potential treatment strategy to manage and prevent male infertility.

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Intrascrotal injection of botulinum toxin A, a male genital aesthetic demand: Technique and limits

Cited by 6 publications

References 14 publications

Cosmetic male genital surgery: a narrative review

Cosmetic male genital surgery: a narrative review

Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

Single injection of very mild dose BOTOX in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

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