Intrascrotal Wilms' tumor developing in a heterotopic renal anlage of probable mesonephric origin

Orlowski, James P.; Levin, Howard S.; Dyment, Paul G.

doi:10.1016/s0022-3468(80)80527-6

Cited by 54 publications

(17 citation statements)

References 4 publications

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“…In contrast to the published Wilms' tumors associated with the gonads (Orlowski et al, 1980;Sahin and Benda, 1988, and references therein), this Wilms' tumor was completely confined to the adult testis. T h e presence of CIS in the testicular parenchyma strongly suggests its germ cell origin (Skakkebzk et al, 1987), in agreement with the hypotriploid D N A content (Oosterhuis et al, 1989).…”

Section: Discussioncontrasting

confidence: 74%

Origin and biology of a testicular wilms' tumor

Gillis¹,

Oosterhuis²,

Schipper

et al. 1994

Genes Chromosomes & Cancer

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A pure triphasic testicular Wilms' tumor, without teratomatous elements, was studied using multiple techniques. Carcinoma in situ (CIS), the characteristic precursor of testicular germ cell tumors of adults (TGCTs), was found in the adjacent parenchyma. Flow cytometric analysis showed a single hypotriploid tumor stem line. Karyotyping of the tumor revealed some numerical and structural abnormalities, including an i(12p), the chromosomal marker of TGCTs. In situ hybridization supported the karyotypic findings, and showed a similar numerical distribution in CIS and the tumor. Molecular analysis of the tumor illustrated that all short arms of chromosome 12, including i(12p), were of maternal origin. No 12q deletions were detected. In spite of complete loss of the paternal 11p13 band, the zinc finger regions and exons 2 and 6 of the WT1 gene contained no aberrations. Therefore, this tumor suppressor gene is not inactivated due to aberrations in the studied regions. In addition, all four WT1 alternative transcripts were expressed in the tumor. No aberrations were found in chromosomal bands 11p15.5, 16q22.1, and 16q24. Both parental alleles of the human imprinted genes H19 and IGF2 were expressed in the tumor. This is the first report on the chromosomal and molecular characterization of an extrarenal Wilms' tumor. Its germ cell origin was unequivocally demonstrated.

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Section: Discussioncontrasting

confidence: 74%

Origin and biology of a testicular wilms' tumor

Gillis¹,

Oosterhuis²,

Schipper

et al. 1994

Genes Chromosomes & Cancer

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“…Other theories regarding genesis from heterotrophic metanephric blastemal cells, and undifferentiated mesoderm, have also been postulated [18,20,49]. However, Comerci et al [37] contradict the theory of origin from undifferentiated mediastinum by highlighting the presence of renal glomeruli and tubules, which suggests at least a partially differentiated tissue of origin.…”

Section: Discussionmentioning

confidence: 99%

Extra-renal Wilms’ tumour—is it different?

et al. 2006

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Nephroblastomas (Wilms' tumour) are the most common solid malignancies in childhood, but extra-renal Wilms' tumours are rare entities, and the diagnosis is made only after surgical intervention. However, the embryogenesis and the exact mechanism of occurrence of primary ERWTs is controversial, thereby presenting a number of unanswered questions of great theoretical interests. We present three well-proven cases of extra-renal Wilms' tumour together with a review of the literature based on its histogenesis, its behaviour and its management policies.

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“…1 Wilms postulates that the classical triphasic tumor arises from the remnants of undifferentiated mesodermal tissue before the mesodermic derivatives of myotome, sclerotome and nephrotome develop. 2 Yamamoto et al have aptly described the pathogenesis of its extrarenal location. 1 A common finding that one comes across in extrarenal Wilms' tumor is the presence of a teratomatous element.…”

Section: Conflict Of Interestmentioning

confidence: 99%

Paratesticular extrarenal Wilms' tumor

Yamamoto¹,

Nishizawa²,

Ogiso

2012

Int J of Urology

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Wilms' tumor is a common pediatric malignant tumor, although extrarenal Wilms' tumor (ERWT) is an extremely rare malignancy. While the histological characteristics are the same as in renal Wilms' tumor, the tumor arises from outside the kidney. We experienced a case of ERWT that arose in the paratesticular region.A 7-month-old male infant was admitted to the Nagano Children's Hospital in Nagano, Japan, with a complaint of a right intrascrotal mass. The mass was walnut-sized and had an irregular surface. The right testis was palpated attached to the mass. Ultrasonography of the mass showed an irregular paratesticular solid mass, 2.5 cm in diameter, which had increased blood flow in it (Fig. 1a,b). Systemic examination did not show any other abnormality. Tumor markers (a-fetoprotein, b-subunit of human chorionic gonadotropin and lactate dehydrogenase) were within the normal range. A computed tomography scan of the abdomen showed normal bilateral kidneys. He had a radical orchiectomy with the diagnosis of a paratesticular malignant tumor, and the mass was easily removed. The cut surface of the tumor was milky white, and the mass separated from the testis and the epididymis. The tumor was not adherent to the testis and the epididymis; it also encapsulated a fibrous capsule. Histopathological examination showed the characteristics of Wilms' tumor exhibiting blastemal, stromal and epithelial elements. Some glomeruloid and tubular structures were scattered in the subcapsular area adjacent to the blastema. The features of anaplasia were not shown. Immunohistochemistry showed epithelial membrane antigen was positive in the tubular structure and Vimentin was positive in the stroma. The boy did not receive any adjuvant therapy, and he was alive and disease free at the end of 36 months of follow up.ERWT accounts for just 3% of Wilms' tumors. Approximately 100 well-documented cases have been reported. ERWT arises in the retroperitoneal cavity, 1 the uterus, the pelvis, the thorax and the inguinal region, along the line of the spermatic cord. Just three cases of paratesticular ERWT have been reported. 2 The origin of ERWT remains unclear. The genital and urinary structures are in close proximity

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Intrascrotal Wilms' tumor developing in a heterotopic renal anlage of probable mesonephric origin

Cited by 54 publications

References 4 publications

Origin and biology of a testicular wilms' tumor

Origin and biology of a testicular wilms' tumor

Extra-renal Wilms’ tumour—is it different?

Paratesticular extrarenal Wilms' tumor

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