Intraspecies classification of rhamnose-positive Yersinia pestis strains from natural plague foci of Mongolia

Platonov, M. E.; Evseeva, V. V.; Ефременко, Д. В.; Afanas’ev, M. V.; Verzhutski, D. B.; Кузнецова, И. В.; Shestopalov, M. Yu.; Dentovskaya, Svetlana V.; Куличенко, А. Н.; Балахонов, С. В.; Anisimov, Andrey P.

doi:10.3103/s0891416815010073

Cited by 11 publications

(3 citation statements)

References 16 publications

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“…The data of multilocus variable-number tandem-repeat analysis (MLVA) and clustered regularly interspaced short palindromic repeat (CRISPR) typing of Y. pestis subsp. microtus strains ( 3 , 4 ) suggest that bv. ulegeica (0.PE5) strains from Mongolia represent the most recent guinea pig/human-avirulent branch of the Y. pestis phylogenetic tree.…”

Section: Genome Announcementmentioning

confidence: 99%

Six Whole-Genome Assemblies of Yersinia pestis subsp. microtus bv. ulegeica (Phylogroup 0.PE5) Strains Isolated from Mongolian Natural Plague Foci

et al. 2018

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Section: Genome Announcementmentioning

confidence: 99%

Six Whole-Genome Assemblies of Yersinia pestis subsp. microtus bv. ulegeica (Phylogroup 0.PE5) Strains Isolated from Mongolian Natural Plague Foci

et al. 2018

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“…The main components of this natural focus are populations of Y. pestis 0.PE4 phylogroup strains belonging to Y. pestis subsp. microtus and characterized by high virulence to their main host ( Ochotona pallasi ) and laboratory mice but almost always avirulence or weak virulence for guinea pigs and humans ( 2 ). Although this plague focus is characterized by permanent epizootic activity, its epidemic potential is low, and there were no registered cases of the disease in people ( 3 ).…”

Section: Genome Announcementmentioning

confidence: 99%

Nine Whole-Genome Assemblies of Yersinia pestis subsp. microtus bv. Altaica Strains Isolated from the Altai Mountain Natural Plague Focus (No. 36) in Russia

et al. 2018

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“…имеются экспериментальные данные о высокой вирулентности единичных полевочьих штаммов из закавказского высокогорного очага для морских свинок. неоднородными по вирулентности оказались и штаммы из восточно-кавказского (дагестанского) высокогорного полевочьего очага [6,11,[15][16][17][18][19][20][21][22].…”

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Rhamnose-Positive Strains of Plague Agent: Virulence and Epidemiological Significance

Sludsky

Devdariani

2022

Problemy Osobo Opasnykh Infektsii

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The aim of the review is to show the groundlessness of the unconditional assessment of rhamnose-positive strains of plague pathogen as avirulent for most species of carriers and humans and having no epidemiological significance. The main carriers of rhamnose-positive strains are several species of voles and the Mongolian pika. The vast majority of experts are of the opinion that rhamnose-positive (“vole`s” and “pika`s”) strains of Yersinia pestis are avirulent or weakly virulent for many species of warm-blooded animals and humans, and therefore have no epidemiological significance. However, in a series of experiments on infecting marmots, ground squirrels, and large gerbils with rhamnose-positive strains, some of the experimental animals fell ill acutely and died from the plague. In nature, rhamnose-positive strains have been isolated from carcasses of relatively resistant red marmots. When evaluating the epidemiological significance of rhamnose-positive strains, such an important criterion as the presence or absence of effective factors and pathways of pathogen transmission in foci of the vole and pika types is omitted. Voles and pikas are not eaten; therefore, the contact route of infecting humans in these foci is impossible. The second way of transmission of the pathogen to humans – vector-borne – is difficult due to the lack of migration of vole fleas from burrows to the surface and their low efficiency as vectors. Nevertheless, cases of human infection with rhamnose-positive strains of the plague agent in the Caucasus and Mongolia give grounds to assert that at least some rhamnose-positive strains have a sufficiently high virulence and are capable of causing infectious process in humans as well. Therefore, epidemiological surveillance in the foci of plague of the vole and pika types cannot be totally abandoned. It can be conducted according to an abbreviated scheme.

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Intraspecies classification of rhamnose-positive Yersinia pestis strains from natural plague foci of Mongolia

Cited by 11 publications

References 16 publications

Six Whole-Genome Assemblies of Yersinia pestis subsp. microtus bv. ulegeica (Phylogroup 0.PE5) Strains Isolated from Mongolian Natural Plague Foci

Six Whole-Genome Assemblies of Yersinia pestis subsp. microtus bv. ulegeica (Phylogroup 0.PE5) Strains Isolated from Mongolian Natural Plague Foci

Nine Whole-Genome Assemblies of Yersinia pestis subsp. microtus bv. Altaica Strains Isolated from the Altai Mountain Natural Plague Focus (No. 36) in Russia

Rhamnose-Positive Strains of Plague Agent: Virulence and Epidemiological Significance

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