Intraspecific response ofPinus taedaL. toGrosmannia huntiiandLeptographium terebrantisinfection

Abstract

We examined intraspecific and inter‐year variation in tolerance of Pinus taeda to two ophiostomatoid fungi, Leptographium terebrantis and Grosmannia huntii. Containerized seedlings of P. taeda from 27, 32, 17 and 23 different elite genetic families were artificially inoculated with L. terebrantis and G. huntii in years 2013, 2014, 2016 and 2017, respectively. Six connector families were inoculated every year. Eight weeks post‐inoculation, lesion and occlusion were measured on each seedling to determine the relative susceptibility/tolerance of families to these fungi. Pinus taeda families widely differed in these parameters suggesting intraspecific variation in the susceptibility/tolerance to the inoculated pathogens. The overall tolerance of the connector families to these fungi varied among the experimental years. These results showed that intraspecific variation to L. terebrantis and G. huntii exists among P. taeda families and it could be possible to select tolerant families to minimize the potential impact due to these fungi.

Efficient synthetic methodology for the construction of dihydronaphthalene and benzosuberene molecular frameworks

“…1)]. [1][2][3][4][5][6][7] The structures of these molecules are reminiscent of the natural products colchicine and combretastatin A-4 ( Fig. 1), [8][9][10] which are potent inhibitors of tubulin polymerization.…”

“…13 Synthetic routes to each of the four key molecules (1 -4) were previously established by our laboratory. 1,[3][4][5][6] The synthesis of compounds 1 and 3 was later reported by other groups utilizing different synthetic approaches to these molecular scaffolds. [16][17][18] Our reported 1,3,7 synthetic routes towards compounds 1 and 2 were quite similar and involved a Wittig reaction followed by Eaton's reagent mediated intramolecular Friedel-Crafts acylation to provide the six-seven fused ring system (Scheme 1).…”

“…While our original synthetic methodology towards dihydronaphthalene analogues involved reactions that initiated from existing fused aromatic-cycloalkane or -alkanone six-membered ring systems, 5,6 we subsequently envisioned the synthesis of dihydronaphthalene analogues 3 and 4 through ring-forming methodology similar to that depicted in Scheme 1 for the related benzosuberene analogues. 3,4 Unfortunately, efforts to coax the requisite Wittig reaction (Scheme 3) to proceed using (2-carboxyethyl)triphenylphosphonium bromide with NaH or KOtBu in various solvents (THF, CH 3 OH, and DMF) mimicking our previous methodology 1 proved unsuccessful.…”