Intratarsal Keratinous Cysts of the Meibomian Gland: Distinctive Clinicopathologic and Immunohistochemical Features in 6 Cases

Jakobiec, Frederick A.; Mehta, Manisha; Iwamoto, Mami; Hatton, Mark P.; Thakker, Manoj M.; Fay, Aaron

doi:10.1016/j.ajo.2009.07.033

Cited by 53 publications

(100 citation statements)

References 45 publications

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“…Instead, one could strongly suspect a more common, intratarsal, keratinous cyst of the eyelid, due to its clinical appearance, the fixation of the lesion onto the tarsus, and the subconjunctival location [13]. …”

Section: Discussionmentioning

confidence: 99%

Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location

Abbeel

Ginderdeuren

2018

Ocul Oncol Pathol

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We report the case of a 38-year-old patient with a tubular apocrine adenoma with papillary differentiation. The clinician was challenged in her diagnosis by the initially misleading appearance and ectopic location. Histopathological findings and immunohistochemistry delivered conclusive proof for the correct diagnosis. Therefore, it is important for the ophthalmologist to request histopathological analysis to diagnose and differentiate from malignancy. A complete local excision is recommended to prevent recurrence.

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Section: Discussionmentioning

confidence: 99%

Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location

Abbeel

Ginderdeuren

2018

Ocul Oncol Pathol

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“…2 The clinical characteristics of IKCs are similar to those of chalazia and epidermal inclusion cysts, but there are differentiating features that enable physicians to distinguish them. For example, lesions such as steatocystomas and pilomatrixomas are white to yellow, as are IKCs.…”

Section: Discussionmentioning

confidence: 99%

“…IKCs occasionally have a bluegray color because of the Tyndall effect, and a blue IKC is occasionally misdiagnosed as melanoma. 2 As awareness of IKC increases, histopathological differences between this entity and other diseases are being revealed. Even though IKC and steatocystoma share similar histological findings, such as trichilemmal keratinization, steatocystomas contain sebaceous glands in the cyst wall or adjoining wall.…”

Section: Discussionmentioning

confidence: 99%

“…To excise an IKC, a partial tarsectomy is mandatory because of its firm adhesion to the tarsus, and this procedure that will remarkably reduce recurrence. 2 Surgically, there are following two approaches: transcutaneous and transconjunctival. Patel et al 3 reported that an anterior lid crease approach with full excision of the intratarsal cyst and partial excision of the underlying anterior tarsus is effective for preventing local recurrence and avoiding more complex lid reconstruction.…”

Section: Discussionmentioning

confidence: 99%

“…1 An intratarsal keratinous cyst (IKC), recently described by Jakobiec et al, 2 is an intratarsal mass lesion that originates from the meibomian glands or their ducts. Importantly, IKC has been frequently misdiagnosed as chalazion or other benign eyelid cystic tumors because it is an intratarsal hard nodular mass.…”

Section: Introductionmentioning

confidence: 99%

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Clinical features of intratarsal keratinous cysts

Kim

et al. 2015

Eye

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Purpose Intratarsal keratinous cysts (IKCs) have been frequently misdiagnosed as chalazia or epidermal cysts. We reviewed a series of cases of IKCs to identify clinical features that distinguish IKCs from other eyelid diseases. Methods We retrospectively reviewed the medical records of 17 suspected IKC patients between January 2004 and September 2014. Results Seventeen patients who were clinically suspected to have IKC were enrolled. All patients presented with noninflamed eyelid nodules fixed to the tarsus. Among them, 12 biopsy specimens were available and 11 patients (91.7%) were diagnosed with IKC, with a pathological finding of stratified squamous cell lining with keratin material. The mean patient age was 55.1 years (31-71). Six patients had a surgical history of incision or incomplete excision of the lesion, followed by recurrence. On eyelid eversion, five patients showed a white-yellow nodule, and three patients had a bluish cystic lesion. The diameter of the nodules ranged from 4 to 10 mm. The intracystic material was a milky white fluid. Ten patients underwent a complete surgical excision including partial tarsectomy and there was no recurrence. Conclusions IKC can be distinguished from other intratarsal lesions by a characteristic tarsal nodule fixed to the tarsus. To prevent recurrence, complete excision with partial tarsectomy is needed.

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Characterization of Retrokeratoprosthetic Membranes in the Boston Type 1 Keratoprosthesis

Stacy¹

2011

Arch Ophthalmol

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To evaluate retroprosthetic membranes that can occur in 25% to 65% of patients with the Boston type 1 keratoprosthesis (KPro).Methods: Two patients with Peter anomaly and 2 with neurotrophic scarred corneas underwent revisions of their type 1 KPros because of visually compromising retroprosthetic membranes. The excised membranes were studied by light microscopy with hematoxylin-eosin, periodic acid-Schiff, and toluidine blue stains. Immunohistochemical and transmission electron microscopic examination were also used.Results: Light microscopic examination revealed that the retro-KPro fibrous membranes originated from the host's corneal stroma. These mildly to moderately vascularized membranes grew through gaps in the Descemet membrane to reach behind the KPro back plate and adhere to the anterior iris surface, which had undergone partial lysis. In 2 cases, the fibrous membranes merged at the pupil with matrical portions of metaplastic lens epithelium, forming a bilayered structure that crossed the optical axis. Retro-KPro membranes stained positively for ␣-smooth muscle actin but negatively for pancytokeratin. Electron microscopy confirmed the presence of actin filaments within myofibroblasts and small surviving clusters of metaplastic lens epithelial cells.Conclusions: Stromal downgrowth, rather than epithelial downgrowth, was the major element of the retro-KPro membranes in this series. Metaplastic lens epithelium also contributed to opacification of the visual axis. Florid membranous inflammation was not a prominent finding and thus probably not a requisite stimulus for membrane development. Further advances in prosthetic design and newer antifibroproliferative agents may reduce membrane formation.

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Intratarsal Keratinous Cysts of the Meibomian Gland: Distinctive Clinicopathologic and Immunohistochemical Features in 6 Cases

Cited by 53 publications

References 45 publications

Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location

Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location

Clinical features of intratarsal keratinous cysts

Characterization of Retrokeratoprosthetic Membranes in the Boston Type 1 Keratoprosthesis

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