Intrathecal Administration of Human Leukocyte Interferon to a Patient with Subacute Sclerosing Panencephalitis

Nakagawa, Masao; Michihata, Takashi; Yoshioka, Hiroshi; Sawada, Tadashi; Kusunoki, Tomoichi; Kíshida, Tsunataro

doi:10.1111/j.1651-2227.1985.tb10973.x

Cited by 14 publications

(1 citation statement)

References 4 publications

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“…This is in spite of the observations that IFN may be involved in the establishment of persistent infections by measles virus in vitro (24,43) and that it can serve as a marker for persistent CNS infection by canine distemper virus in dogs (49). Furthermore, in trials of intrathecal or intraventricular IFN as a treatment for SSPE (6,7,9,22,(39)(40)(41)(42)47), clinical improvement has been observed in 9 of 19 (47%) patients, which is in contrast with the approximately 10% of patients with SSPE that show spontaneous stabilization or improvement (44,45). Furthermore, by combining the results reported with some of these trials with those reported in other studies (6,7,9,22,29), it can be seen that of 20 patients with SSPE whose cerebrospinal fluid was assayed for IFN by bioassay before treatment with IFN, only 4 (20%) had detectable levels.…”

Section: Discussionmentioning

confidence: 99%

Identification of a nonproductive, cell-associated form of measles virus by its resistance to inhibition by recombinant human interferon

Carrigan¹,

Kabacoff²

1987

J Virol

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Subacute sclerosing panencephalitis (SSPE) is a fatal disease in children and young adults that is caused by persistent infection of the central nervous system (CNS) by a nonproductive, cell-associated form of measles virus. Using an experimental model for SSPE (LEC viral strain in newborn hamsters), we have shown previously that establishment of such CNS infections involves selective elimination from the CNS of productively infected cells by host defensive mechanisms, coupled with the selective sparing of cells carrying nonproductive viral forms. That interferon (IFN) may play a role in this process was suggested by the disappearance of productively infected cells from the CNS tissues prior to the appearance of antiviral antibodies and by the demonstration of cell-associated, IFN-resistant viral variants in the virus stocks that were used. Results of this study support these conclusions by showing that similar IFN-resistant viral variants are present in the HBS strain of SSPE-derived measles virus and that these variants, in the presence of IFN, have properties that are similar to those of naturally occurring cell-associated'strains of SSPE viruses, e.g., DR, IP3, and Biken. These IFN-resistant forms of HBS virus were isolated and were shown to maintain their resistance to inhibition by IFN after cloning. However, on removal of IFN, they reverted to productive forms similar to the parental HBS virus. The potential role of such viral forms in the pathogenesis of SSPE is discussed.

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