Intrathecal fentanyl decreases the optimal effect site concentration of propofol during spinal anaesthesia

Lee, Jong Seok; Kim, J. S.; Kim, M. K.; Kim, S. H.; Kim, J. Y.

doi:10.1111/aas.12307

Cited by 1 publication

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect-site concentration of propofol at a dose of 3 mg/kg/hr in our study was approximately 1.0 μg/ml at 20 min after administration, reaching 1.3 μg/ml at 60 min after the start of propofol administration. These values seem to agree with the findings of previous reports [ 16 – 18 ]. The optimal effect-site concentration of propofol has been reported to be 0.87–1.67 μg/ml in patients with spinal anesthesia [ 16 ].…”

Section: Discussionsupporting

confidence: 93%

“…These values seem to agree with the findings of previous reports [ 16 – 18 ]. The optimal effect-site concentration of propofol has been reported to be 0.87–1.67 μg/ml in patients with spinal anesthesia [ 16 ]. Another clinical study reported that 1.5–2.5 μg/ml administered using target-controlled infusion produced a relatively better result, compared with higher doses (3.0–4.0 μg/ml).…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Optimal and safe standard doses of midazolam and propofol to achieve patient and doctor satisfaction with dental treatment: A prospective cohort study

et al. 2017

View full text Add to dashboard Cite

BackgroundThe incidences of morbidity and mortality caused by pharmacosedation for dental treatment have not yet reached zero. Adverse events are related to inappropriate respiratory management, mostly originating from an overdose of sedatives. Since sedation is utilized for the satisfaction of both the dentist and the patient, the optimal dose should be minimized to prevent adverse events. We attempted to define the optimal doses of midazolam and propofol required to achieve high levels of patient and dentist satisfaction.MethodsOne thousand dental patients, including those undergoing third molar extractions, were enrolled in this study. A dose of 1 mg of midazolam was administered at 1-minute intervals until adequate sedation was achieved. Propofol was then infused continuously to maintain the sedation level. Both the patients and the dentists were subsequently interviewed and asked to complete a questionnaire. A multivariate logistic regression analysis was used to examine the factors that contributed to patient and dentist satisfaction.ResultsThe peak midazolam dose resulting in the highest percentage of patient satisfaction was 3 mg. Both a lower dose and a higher dose reduced patient satisfaction. Patient satisfaction increased with an increasing dosage of propofol up until 4 mg/kg/hr, reaching a peak of 78.6%. The peak midazolam dose resulting in the highest percentage of dentist satisfaction (78.8%) was 2 mg. Incremental propofol doses reduced dentist satisfaction, in contrast to their effect on patient satisfaction. The strongest independent predictors of patient satisfaction and dentist satisfaction were no intraoperative memory (OR, 5.073; 95% CI, 3.532–7.287; P<0.001) and unintentional movements by the patient (OR, 0.035; 95% CI, 0.012–0.104; P<0.001), respectively. No serious adverse events were reported.ConclusionWe found that 3 mg of midazolam and 3 mg/kg/hr of propofol may be the optimal doses for maximizing both patient and dentist satisfaction. Although this level of sedation is relatively light, memory loss and an absence of unintentional patient movements can be expected without adverse events.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Optimal and safe standard doses of midazolam and propofol to achieve patient and doctor satisfaction with dental treatment: A prospective cohort study

et al. 2017

View full text Add to dashboard Cite

show abstract

Intrathecal fentanyl decreases the optimal effect site concentration of propofol during spinal anaesthesia

Abstract: The EC50 of the effect-site concentration of propofol for sedation decreased from 1.67 ± 0.28 mcg/ml to 0.87 ± 0.15 mcg/ml with the addition of 25 mcg fentanyl to a spinal anaesthetic in patients undergoing urologic surgery.

Cited by 1 publication

References 22 publications

Optimal and safe standard doses of midazolam and propofol to achieve patient and doctor satisfaction with dental treatment: A prospective cohort study

Optimal and safe standard doses of midazolam and propofol to achieve patient and doctor satisfaction with dental treatment: A prospective cohort study

Contact Info

Product

Resources

About