Intrathecal injection of human placental mesenchymal stem cells derived exosomes significantly improves functional recovery in spinal cord injured rats

Soleimani, Afsane; Oraee Yazdani, Saeed; Pedram, Mirsepehr; Saadinam, Fatemeh; Rasaee, Mohammad Javad; Soleimani, Masoud

doi:10.1007/s11033-023-08972-7

Mol Biol Rep

2024

DOI: 10.1007/s11033-023-08972-7

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Intrathecal injection of human placental mesenchymal stem cells derived exosomes significantly improves functional recovery in spinal cord injured rats

Afsane Soleimani,

Saeed Oraee Yazdani,

Mirsepehr Pedram

et al.

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Cited by 4 publications

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Injectable alginate chitosan hydrogel as a promising bioengineered therapy for acute spinal cord injury

Saadinam,

Azami,

Pedram

et al. 2024

Sci Rep

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Dealing with spinal cord injuries presents problematic due to multiple secondary mechanisms. Beyond primary concerns like paralysis and disability, complications including urinary, gastrointestinal, cardiac, and respiratory disorders, along with substantial economic burdens may occur. Limited research focuses on modeling and treating contusion and compression injuries. Tissue engineering emerges as an innovative treatment, targeting lesion pathophysiology. This study was evaluated implanting injectable biomaterials into injury-induced cavity before glial scar formation, avoiding tissue incisions and minimizing further damage. The efficacy of injectable alginate/thiolated chitosan hydrogel was investigated for acute spinal cord injury induced by Vanický method in Wistar rats. Three days post-injury, hydrogel was administrated through microinjection after laminectomy. After 60 days, the hydrogel group demonstrated notable motor function enhancement compared to the control by the BBB locomotor test ( P < 0.05). However, no statistically significant differences were observed in MRI assessment concerning lesion severity. Stereological and histopathological evaluations revealed a reduction in vacuole volume and the presence of axon profiles within the scaffold ( P < 0.05), alongside reduced infiltration of inflammatory and Gitter cells in the hydrogel group, although the latter was not statistically significant compared to the control. Thiolated chitosan/ alginate hydrogel implantation may be regarded as a promising treatment to enhance motor function by restraining destructive processes post-acute spinal cord injury.

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Injectable alginate chitosan hydrogel as a promising bioengineered therapy for acute spinal cord injury

Saadinam,

Azami,

Pedram

et al. 2024

Sci Rep

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Navigating the tumor microenvironment: mesenchymal stem cell-mediated delivery of anticancer agents

Waqar,

Zaman,

Khan

et al. 2024

Journal of Drug Targeting

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The Placenta as a Source of Human Material for Neuronal Repair

Dallatana,

Cremonesi,

Pezzini

et al. 2024

Biomedicines

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Stem cell therapy has the potential to meet unsolved problems in tissue repair and regeneration, particularly in the neural tissues. However, an optimal source has not yet been found. Growing evidence indicates that positive effects produced in vivo by mesenchymal stem cells (MSCs) can be due not only to their plasticity but also to secreted molecules including extracellular vesicles (EVs) and the extracellular matrix (ECM). Trophic effects produced by MSCs may reveal the key to developing effective tissue-repair strategies, including approaches based on brain implants or other implantable neural electrodes. In this sense, MSCs will become increasingly valuable and needed in the future. The placenta is a temporary organ devoted to protecting and supporting the fetus. At the same time, the placenta represents an abundant and extremely convenient source of MSCs. Nonetheless, placenta-derived MSCs (P-MSCs) remain understudied as compared to MSCs isolated from other sources. This review outlines the limited literature describing the neuroregenerative effects of P-MSC-derived biomaterials and advocates for exploiting the potential of this untapped source for human regenerative therapies.

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Intrathecal injection of human placental mesenchymal stem cells derived exosomes significantly improves functional recovery in spinal cord injured rats

Cited by 4 publications

References 50 publications

Injectable alginate chitosan hydrogel as a promising bioengineered therapy for acute spinal cord injury

Injectable alginate chitosan hydrogel as a promising bioengineered therapy for acute spinal cord injury

Navigating the tumor microenvironment: mesenchymal stem cell-mediated delivery of anticancer agents

The Placenta as a Source of Human Material for Neuronal Repair

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