Intrathecal Lactate Concentration and Spinal Cord Injury in Thoracoabdominal Aortic Surgery

Casiraghi, Giuseppina Maria; Poli, Davide; Landoni, Giovanni; Buratti, Luca; Imberti, Roberto; Plumari, Valentina Paola; Túri, Sándor; Mennella, Roberta; Messina, M.; Covello, Remo Daniel; Carozzo, Andrea; Motta, Andrea; Zangrillo, Alberto

doi:10.1053/j.jvca.2010.03.006

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…These results have been reproduced in a more recent study by Casiraghi et al where 4 patients developed SCI, and CSF lactate was significantly higher before, during and after surgery [32]. Our previous work has already shown the ability of our sensor to accurate measure lactate at physiological levels with our sensor with tangible evidence that this could be possible in real time [20][21]24].…”

Section: Discussionsupporting

confidence: 84%

A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

et al. 2015

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Section: Discussionsupporting

confidence: 84%

A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

et al. 2015

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“…Biomarkers after traumatic spinal cord injury are fairly well developed [ 2 , 12 ]. However, biomarkers for SCI after aortic surgery are not as well-established, although some exist, where rises in intrathecal lactate is an early sign of spinal cord ischemia [ 8 , 18 ]. Also, S100b increases intrathecally after spinal cord ischemia, but this takes longer, up to 6 h [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury

Lindblom

Shen

Axén

et al. 2018

J. of Cardiovasc. Trans. Res.

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Surgery on the arch or descending aorta is associated with significant risk of neurological complications. As a consequence of intubation and sedation, early neurologic injury may remain unnoticed. Biomarkers to aid in the initial diagnostics could prove of great value as immediate intervention is critical. Twenty-three patients operated in the thoracic aorta with significant risk of perioperative neurological injury were included. Cerebrospinal fluid (CSF) and serum were obtained preoperatively and in the first and second postoperative days and assessed with a panel of 92 neurological-related proteins. Three patients suffered spinal cord injury (SCI), eight delirium, and nine hallucinations. There were markers in both serum and CSF that differed between the affected and non-affected patients (SCI; IL6, GFAP, CSPG4, delirium; TR4, EZH2, hallucinations; NF1). The study identifies markers in serum and CSF that reflect the occurrence of neurologic insults following aortic surgery, which may aid in the care of these patients.Electronic supplementary materialThe online version of this article (10.1007/s12265-018-9835-8) contains supplementary material, which is available to authorized users.

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“…Casiraghi et al [24] demonstrated that in 4 of 16 patients who developed neurological injury following TAAR, CSF lactate was significantly higher at all-time points including baseline, intra and postoperatively.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, following their discovery they are released in a variety of other stresses, including ischaemia. Hecker et al choose to study HSP27 and HSP70 families for their association with cellular protection and recovery after a near-lethal stress [24] .…”

Section: Discussionmentioning

confidence: 99%

Could Cerebrospinal Fluid Biomarkers Offer Better Predictive Value for Spinal Cord Ischaemia Than Current Neuromonitoring Techniques During Thoracoabdominal Aortic Aneurysm Repair – A Systematic Review

Harky¹,

Fok²,

Fraser³

et al. 2019

Braz J Cardiovasc Surg

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Objective Cerebrospinal fluid (CSF) drainage is a technique that has significantly reduced the incidence of spinal cord ischaemia (SCI). We present results of a systematic review to assess the literature on this topic in relation to thoracoabdominal aortic aneurysm repair (TAAR). Methods Major medical databases were searched to identify papers related to CSF biomarkers measured during TAAAR. Results Fifteen papers reported measurements of CSF biomarkers with 265 patients in total. CSF biomarkers measured included S-100ß, neuron-specific endolase (NSE), lactate, glial fibrillary acidic protein A (GFPa), Tau, heat shock protein 70 and 27 (HSP70, HSP27), and proinflammatory cytokines. Lactate and S-100ß were reported the most, but did not correlate with SCI, which was also the case with NSE and TAU. GFPa showed significant CSF level rises, both intra and postoperative in patients who suffered SCI and warrants further investigation, similar results were seen with HSP70, HSP27 and IL-8. Conclusions Although there is significant interest in this topic, there still remains a significant lack of high-quality studies investigating CSF biomarkers during TAAR to detect SCI. A large and multicentre study is required to identify the significant role of each biomarker.

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Intrathecal Lactate Concentration and Spinal Cord Injury in Thoracoabdominal Aortic Surgery

Cited by 9 publications

References 26 publications

A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury

Could Cerebrospinal Fluid Biomarkers Offer Better Predictive Value for Spinal Cord Ischaemia Than Current Neuromonitoring Techniques During Thoracoabdominal Aortic Aneurysm Repair – A Systematic Review

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