Intrathecal local anesthetic distribution with the new Spinocath catheter

Holst, D.; Möllmann, Michael; Scheuch, Eberhard; Meissner, Konrad; Wendt, Michael

doi:10.1016/s1098-7339(98)90028-1

Cited by 17 publications

(13 citation statements)

References 5 publications

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“…In this study, the suppressive effects of lidocaine appeared at a higher plasma concentration than is observed in the clinical setting in humans. However, after local application or tissue infiltration of this drug, lidocaine tissue concentration is typically in the millimolar range (17). Therefore, we cannot exclude the possibility that lidocaine adversely affects the immune system when it is administered locally.…”

Section: Discussionmentioning

confidence: 99%

Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice

Kawasaki¹,

Choudhry²,

Schwacha³

et al. 2006

American Journal of Physiology-Cell Physiology

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Traumatic and/or surgical injury as well as hemorrhage induces profound suppression of cellular immunity. Although local anesthetics have been shown to impair immune responses, it remains unclear whether lidocaine affects lymphocyte functions following trauma-hemorrhage (T-H). We hypothesized that lidocaine will potentiate the suppression of lymphocyte functions after T-H. To test this, we randomly assigned male C3H/HeN (6–8 wk) mice to sham operation or T-H. T-H was induced by midline laparotomy and ∼90 min of hemorrhagic shock (blood pressure 35 mmHg), followed by fluid resuscitation (4× shed blood volume in the form of Ringer lactate). Two hours later, the mice were killed and splenocytes and bone marrow cells were isolated. The effects of lidocaine on concanavalin A-stimulated splenocyte proliferation and cytokine production in both sham-operated and T-H mice were assessed. The effects of lidocaine on LPS-stimulated bone marrow cell proliferation and cytokine production were also assessed. The results indicate that T-H suppresses cell proliferation, Th1 cytokine production, and MAPK activation in splenocytes. In contrast, cell proliferation, cytokine production, and MAPK activation in bone marrow cells were significantly higher 2 h after T-H compared with shams. Lidocaine depressed immune responses in splenocytes; however, it had no effect in bone marrow cells in either sham or T-H mice. The enhanced immunosuppressive effects of lidocaine could contribute to the host's enhanced susceptibility to infection following T-H.

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Section: Discussionmentioning

confidence: 99%

Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice

Kawasaki¹,

Choudhry²,

Schwacha³

et al. 2006

American Journal of Physiology-Cell Physiology

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“…The administration of the hyperbaric local anesthetic through the Spinocath TM did not show poor distribution, without an elevated peak in the concentration of the anesthetic, and without the risk of developing cauda equina syndrome 24 . Since in the present case the patient had three large hernias, it was decided to reduce the baricity of the solution by changing the glucose concentration and maintaining the concentration of bupivacaine (0.5%) and lidocaine (2%).…”

Section: Discussionmentioning

confidence: 91%

Raquianestesia contínua com altas doses de anestésicos locais

Imbelloni¹,

Neto²,

Ganem³

2010

Rev. Bras. Anestesiol.

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Summary: Imbelloni LE, Gasparini Neto S, Ganem EM -Continuous Spinal Anesthesia with High Dose of Local Anesthetics. Background and objectives:Better control of the level, intensity, and duration of spinal analgesia represents the greatest advantages of continuous spinal anesthesia. With the advent of intermediate catheters (over-the-needle catheter) and its low incidence of headaches and neurological symptoms, the technique has been gaining credibility. The objective of this paper is to report the possible safety of the new catheter with a large dose of hyperbaric 0.5% bupivacaine with 1.6% glucose associated with hyperbaric 2% lidocaine with 1.6% glucose.

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“…This is supported by electron microscopic observations showing that withdrawal of a CTN needle-catheter left a puncture hole with a smooth margin that remained open following removal of the catheter, whereas withdrawal of a CON needle-catheter left a smaller puncture hole with irregular margins that closed almost completely after withdrawal of the catheter. 14 The Spinocath system, which has a CON design, already takes advantage of this feature to minimize leakage of cerebrospinal fluid during continuous spinal anesthesia. 14 Together, these data suggest that the larger diameter of the CON catheter results in a more effective seal created by the surrounding skin, minimizing the chance of leakage at the insertion site.…”

Section: Discussionmentioning

confidence: 99%

“…14 The Spinocath system, which has a CON design, already takes advantage of this feature to minimize leakage of cerebrospinal fluid during continuous spinal anesthesia. 14 Together, these data suggest that the larger diameter of the CON catheter results in a more effective seal created by the surrounding skin, minimizing the chance of leakage at the insertion site.…”

Section: Discussionmentioning

confidence: 99%

Less leakage and dislodgement with a catheter-over-needle versus a catheter-through-needle approach for peripheral nerve block: an ex vivo study

Tsui

2012

Can J Anesth/J Can Anesth

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Less leakage and dislodgement with a catheter-over-needle versus a catheter-through-needle approach for peripheral nerve block: an ex vivo study Moins de fuites et de déplacements avec un cathéter par-dessus l'aiguille qu'avec un cathéter à travers l'aiguille pour un bloc nerveux périphérique: une étude ex vivo Abstract Purpose The objective of this study was to compare the catheter-through-needle (CTN) and catheter-over-needle (CON) catheterization techniques ex vivo by measuring leak pressure around the catheter and the catheter's resistance to pulling force. Methods Using an ex vivo porcine limb model, we compared the conventional CTN design with the CON design with respect to the ability to resist leakage at the catheter insertion site under high injection pressure and the force required to withdraw the catheter from tissue. One CON assembly (MultiSet, Pajunk) and three CTN assemblies (Contiplex, B.Braun; StimuCath, Arrow; Stimulong Sono, Pajunk) were studied. Ten porcine hind limbs were used to test leakage and another ten were used to measure withdrawal force. Catheters were placed at angles of 15°and 30°at depths of 3 cm and 5 cm. Leakage was assessed visually at the insertion site, and pressure was measured at the moment leakage occurred. Withdrawal force was measured by pulling the catheter from the tissue. Results No evidence of leakage was detected at the CON catheter insertion site at the highest pressure applied (1,000 mmHg) (n = 40). The CON assembly withstood significantly higher injection pressure than the CTN catheters without causing leaks at the catheter insertion site [CON, mean (standard deviation) [ 1,000 (0)

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Intrathecal local anesthetic distribution with the new Spinocath catheter

Cited by 17 publications

References 5 publications

Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice

Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice

Raquianestesia contínua com altas doses de anestésicos locais

Less leakage and dislodgement with a catheter-over-needle versus a catheter-through-needle approach for peripheral nerve block: an ex vivo study

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