Intrathecal minocycline does not block the adverse effects of repeated, intravenous morphine administration on recovery of function after SCI

Rau, Josephina; Weise, Lara; Moore, Robbie; Terminel, Mabel N.; Brakel, Kiralyn; Cunningham, Rachel; Bryan, J. G. H.; Stefanov, Alexander; Hook, Michelle A.

doi:10.1016/j.expneurol.2022.114255

Search citation statements

Order By: Relevance

Paper Sections

Select...

Advances and Challenges In Clinical Mirna Treatment1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 111 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, studies have shown that morphine use can increase inflammation and mortality at the injured site, and minocycline pretreatment can not only reduce the number of macrophages at the lesion site, particularly pro-inflammatory macrophages, but also block the negative effects of morphine on functional recovery after injury [ 239 ]. However, the author's further studies demonstrated that minocycline could only prevent the harmful effects of a single intrathecal morphine injection but could not prevent the adverse effects of repeated morphine injections [ 240 ]. More research is needed to determine the viability of using it in conjunction with opioids to treat SCI.…”

Section: Advances and Challenges In Clinical Mirna Treatmentmentioning

confidence: 99%