Intrathecal Morphine Pump as a Treatment Option in Chronic Pain of Nonmalignant Origin

Angel, Ian; Carey, Michael E.; Gould, Harry J.

doi:10.1097/00006123-199609000-00105

Cited by 28 publications

(57 citation statements)

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“…It is indicated for pain reduction in stage 3 of the WHO step pattern during cancer therapy, and occasionally when benign diseases are diagnosed [7,8,11].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Intrathecal Opioid Therapy for the Treatment of Neuropathic Cancer Pain Conditions

Becker

Jakob

Uhle

et al. 2000

Stereotact Funct Neurosurg

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The effectiveness of intrathecal opioid therapy when applied to different pain mechanisms, in particular neuropathic and nociceptive pain conditions, was studied retrospectively in 43 patients suffering from cancer pain. On the basis of clinical and radiological data, the pain mechanisms were categorized as nociceptive (n = 23) and neuropathic (n = 20). The average duration of treatment of nociceptive pain was 5 months, of neuropathic pain only 2.5 months. The initial median reduction of pain with intrathecal opioid therapy was 77.8% for nociceptive and 61.1% for neuropathic pain. Long-term results with patients suffering nociceptive pain showed a continuing good median pain reduction of 66.7%. Patients suffering from neuropathic pain showed poor long-term results (11.1% median pain reduction). Neuropathic pain in the extremities reacted least to the application of intrathecal opioids. Optimal results were obtained for nociceptive pain in the trunk area of the body.

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“…It is indicated for pain reduction in stage 3 of the WHO step pattern during cancer therapy, and occasionally when benign diseases are diagnosed [7,8,11].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Intrathecal Opioid Therapy for the Treatment of Neuropathic Cancer Pain Conditions

Becker

Jakob

Uhle

et al. 2000

Stereotact Funct Neurosurg

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“…[74][75][76] Other side effects mentioned were provocation of asthma, 86 insomnia, 86 dry mouth, 86 nightmares, 86 myoclonic jerk/ spasm, 86 dizziness, 76,86 loss of appetite, 86 diarrhea, 76 and headache. 76 Hardware complications were reported commonly.…”

Section: Complicationsmentioning

confidence: 99%

Programmable Intrathecal Opioid Delivery Systems for Chronic Noncancer Pain: A Systematic Review of Effectiveness and Complications

Turner¹,

Sears

Loeser

2007

The Clinical Journal of Pain

140

120

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The studies reviewed found improvement in pain and functioning on average among patients with chronic noncancer pain who received permanent IDDS. However, their methodologic limitations preclude conclusions concerning the effectiveness of this technology long-term and as compared with other treatments. Drug side effects and hardware complications were common. Suggestions are made for methodologic improvements in future studies.

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“…Furthermore, the value of epidural injections for the treatment of existing PHN has not been evaluated (van Wijck et al, 2010). Continuous infusions of analgesic agents (typically an opioid or local anesthetic) via an externalized intrathecal catheter or internalized intrathecal pump may also be used for the treatment of PHN, although no controlled trials examining the analgesic efficacy of these modalities are available (Angel et al, 1998;Nitescu et al, 1998). In extreme cases, refractory to all treatment options, other interventional strategies were described in the literature.…”

Section: Interventional Managementmentioning

confidence: 99%

Zoster-Associated Pain and Post Herpetic Neuralgia

Ursini¹,

Tontodonati²,

Polilli³

et al. 2012

Herpesviridae - A Look Into This Unique Family of Viruses

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Intrathecal Morphine Pump as a Treatment Option in Chronic Pain of Nonmalignant Origin

Cited by 28 publications

References 0 publications

The Significance of Intrathecal Opioid Therapy for the Treatment of Neuropathic Cancer Pain Conditions

The Significance of Intrathecal Opioid Therapy for the Treatment of Neuropathic Cancer Pain Conditions

Programmable Intrathecal Opioid Delivery Systems for Chronic Noncancer Pain: A Systematic Review of Effectiveness and Complications

Zoster-Associated Pain and Post Herpetic Neuralgia

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