Intrathecal Sufentanil Is More Potent Than Intravenous for Postoperative Analgesia After Total-Hip Replacement

Abstract

After total-hip replacement, intrathecal route of sufentanil administration rapidly offers excellent analgesia of better quality and longer duration when compared with the intravenous route.

Intrathecal sufentanil decreases the median effective dose (ED50) of intrathecal hyperbaric ropivacaine for caesarean delivery

“…Although the result on sedation during caesarean delivery is controversial, we think that mild sedation is beneficial to the patients during caesarean delivery based on our experience in clinical practice. Additionally, we noticed that the intensity of motor block was less in Group RS compared with Group R, which is also in agreement with a previous study 29 …”

Effects of intrathecal and i.v. small-dose sufentanil on the median effective dose of intrathecal bupivacaine for Caesarean section

“…route after total-hip replacement. 5 These results support the superiority of a spinal mechanism of action of intrathecally administered sufentanil. When epidurally administered, the mechanism of action of sufentanil appears to be related to the size of the dose.…”

Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties

“…Ziconotide, a synthetic equivalent of the venom of a marine snail, exerts its effect by binding and blocking voltage‐sensitive calcium channels . Opioids show postoperative analgesia when administered intrathecally . Intrathecal NSAIDs have been tested for their analgesic efficacy in patients but are not used in current clinical practice .…”