Intrathecal synthesis of anti-viral antibodies in pediatric patients

Denne, C.; Kleines, Michael; Dieckhöfer, A.; Ritter, Klaus; Merz, U; Häusler, Martin

doi:10.1016/j.ejpn.2006.10.003

Cited by 19 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous investigations focused mainly on determining the presence of EBV latently infected B lymphocytes within the brain tissue [10], [11], [12], [13] and/or direct viral presence in the CSF [14], [15], [16], [17]. However, results have been highly discordant, with some authors reporting the presence of EBV-infected cells in the vast majority of MS cases [10], [13], whilst others have failed to demonstrate the presence of EBV or showed positivity in only a minority of MS brain tissues or CSFs [11], [12], [16], [18].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Detection of Epstein-Barr Virus DNA in Cerebrospinal Fluid and Blood Samples of Patients with Relapsing-Remitting Multiple Sclerosis

et al. 2014

View full text Add to dashboard Cite

The presence of Epstein-Barr Virus (EBV) DNA in cerebrospinal fluid (CSF) and peripheral blood (PB) samples collected from 55 patients with clinical and radiologically-active relapsing-remitting MS (RRMS) and 51 subjects with other neurological diseases was determined using standardized commercially available kits for viral nucleic acid extraction and quantitative EBV DNA detection. Both cell-free and cell-associated CSF and PB fractions were analyzed, to distinguish latent from lytic EBV infection. EBV DNA was detected in 5.5% and 18.2% of cell-free and cell-associated CSF fractions of patients with RRMS as compared to 7.8% and 7.8% of controls; plasma and peripheral blood mononuclear cells (PBMC) positivity rates were 7.3% and 47.3% versus 5.8% and 31.4%, respectively. No significant difference in median EBV viral loads of positive samples was found between RRMS and control patients in all tested samples. Absence of statistically significant differences in EBV positivity rates between RRMS and control patients, despite the use of highly sensitive standardized methods, points to the lack of association between EBV and MS disease activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Quantitative Detection of Epstein-Barr Virus DNA in Cerebrospinal Fluid and Blood Samples of Patients with Relapsing-Remitting Multiple Sclerosis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Studies that detected EBV DNA in brain tissue [30,39] and CSF [21,26,30,32,33] (Table 7) failed to prove the association between the virus and the disease. Only the results of the following studies were positive: AlvarezLafuente et al [21], Mancuso et al [32] and Sanders et al [39].…”

Section: Detection Of Ebv Dna In Brain Tissue and In Csfmentioning

confidence: 99%

Relation between Epstein-Barr virus and multiple sclerosis: analytic study of scientific production

Santiago

Gutiérrez

Sorlózano

et al. 2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Numerous studies have been carried out to determine whether infection by the Epstein-Barr virus (EBV) can be considered as a risk factor for multiple sclerosis (MS). This work is a meta-analysis of casecontrol observational studies published before January 2009 aimed at assessing the degree of association between EBV and MS infections. A Medline electronic database search was carried out using "Epstein-Barr virus" and "multiple sclerosis" as keywords, from which we selected 30 published studies that met our methodology criteria. We found an association between MS and an exposure to EBV, studied by determining the anti-VCA IgG antibodies (odds ratio [OR]=5.5; 95% confidence interval [CI]=3.37-8.81; p<0.0001), anti-complex EBNA IgG (OR=5.4; 95% CI= 2.94-9.76; p<0.0001) and anti-EBNA-1 IgG (OR=12.1; 95% CI=3. 13-46.89; p<0.0001). No significant association could be found when studying anti-EA IgG (OR=1.3; 95% CI=0.68-2.35; p=0.457), EBV DNA in serum (OR= 1.8; p=0.051) and DNA in brain tissues and in cerebrospinal fluid (CSF) (OR=0.9; 95% CI=0.38-2.01; p=0.768). This meta-analysis detected an association between infection by EBV and MS through the investigation of antibodies, mainly anti-EBNA-1, anticomplex EBNA and anti-VCA IgG.

show abstract

“…11 Benzer klinik ile başvuran olguları içeren bir çalışmada serebral viral enfeksiyon tespit edilmiş fakat bu vakalarda da SVT saptanmamıştır. 12 Virchow triadı olarak adlandırılan, venöz staz, hiperkoagülasyon ve endotel hasarını, venöz trombozunun oluşumundan sorumlu temel mekanizmadır. 13 SVT etiyolojisinde lokal veya jeneralize enfeksiyonların sistemik etkileri rol oynar.…”

Section: Discussionunclassified