Intrathecal synthesis of IgM in early multiple sclerosis

Sharief, MK

doi:10.1111/j.1600-0404.1991.tb04989.x

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…4,5 Intrathecal IgM synthesis in adult MS patients has been thought to represent a prognostic marker for a more rapid disease progression, 6 based on interpretations of intrathecal IgM by the linear IgM index. 7 But, as shown recently, the linear evaluation of an index is unsuitable for the statistical comparison of groups 1 and does not allow an unbiased discrimination between blood-derived and brain-derived IgG or IgM. 5 A particular confusion in the field comes from interpretation of the qualitative detection of 'oligoclonal' IgM, mainly propagated by a single group.…”

Section: Introductionmentioning

confidence: 99%

Intrathecal IgM synthesis in pediatric MS is not a negative prognostic marker of disease progression: quantitative versus qualitative IgM analysis

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Intrathecal IgM synthesis in pediatric MS is not a negative prognostic marker of disease progression: quantitative versus qualitative IgM analysis

et al. 2010

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“…Clinical and MRI studies indicate that axonal damage predominantly appears in the early MS and develops as a consequence of inflammatory process (Bendfeldt et al 2009), leading to the most numerous (~ 85% of cases) relapsing-remitting form of the disease (Weiner 2008). Elevated levels of aforementioned pro-inflammatory cytokines and lipid peroxidation in the plasma, cerebrospinal cord, and brain cortex have been found in the patients with MS (Gonsette 2008; Keller and Mattson 1998); a positive correlation has been found between their levels and disease’s activity and severity (Sharief 1991; Navikas and Link 1996). Gonzalo et al (Gonzalo et al 2012) performed targeted lipidome analyses comprising several oxidized phospholipids, lipid peroxidation-derived aldehydes, oxysterols, and oxidized lipids.…”

Section: Discussionmentioning

confidence: 99%

Altered Cerebrospinal Fluid Concentrations of Hydrophobic and Hydrophilic Compounds in Early Stages of Multiple Sclerosis—Metabolic Profile Analyses

et al. 2019

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The lack of a single predictive or diagnostic test in multiple sclerosis (MS) remains a major obstacle in the patient’s care. The aim of this study was to investigate metabolic profiles, especially lipids in cerebrospinal fluid (CSF) using 1 H-NMR spectroscopy and metabolomics analysis to discriminate MS patient group from the control ones. In this study, 19 MS patients and 19 controls, without neurological problems, patients were enrolled. To obtain the CSF metabolic profiles, NMR spectroscopy was used. Hydrophilic and hydrophobic compounds were analyzed using univariate and multivariate supervised analysis orthogonal partial least square discriminant analysis (OPLS-DA). Targeted OPLS-DA analysis of 32 hydrophilic and 17 hydrophobic compounds obtained 9 hydrophilic metabolites and 8 lipid functional groups which had the highest contribution to patient’s group separation. Lower concentrations of CSF hydrophilic and hydrophobic compounds were observed in MS patients as compared to control group. Acetone, choline, urea, 1,3-dimethylurate, creatinine, isoleucine, myo-inositol, leucine, and 3-OH butyrate; saturated and monounsaturated acyl groups of ω–9, ω–7, ω–6, ω–3, and fatty acid, triglycerides, 1,3-DG, 1-MG, and unassigned component signal at 3.33 ppm were the most important signal compounds in group separation. Analysis of metabolic profile of raw CSF and their lipid extract shows decreased levels of many compounds and led to the conclusion that MS patients could have a disturbance in many metabolic pathways perhaps leading to the decreased level of acetyl-CoA and/or inflammation. CSF metabolic profile analyses could be used as a fingerprint for early MS diagnosis.

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“…In contrast to the established method of oligoclonal IgG, the existence of “oligoclonal” IgM as detected after isoelectric focusing is questioned by several groups (Reiber, personal communication). A second source of biased results comes from interpretations of intrathecal IgM by the linear IgM Index (14)). As shown recently the linear evaluation of an Index is unsuitable for statistical comparison of groups (11)).…”

Section: Introductionmentioning

confidence: 99%

Clinical and neurochemical characteristics of pediatric multiple sclerosis – CSF analysis as knowledge base for differential diagnosis and pathophysiology

Rostásy

Reiber

2009

Acta Neuropsychiatr.

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Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system affecting young adults. Although adults and children share important features of the disease, they also differ in some clinical, radiological and laboratory aspects. This review focuses on the neuroimmunological findings in the cerebrospinal fluid of children with MS pointing out that there is already at earliest time of clinical manifestation a neuroimmunological pattern, which differs only in intensity of the humoral immune response but not in frequency and does not support a neuroimmunological difference between early onset from adult onset MS. The humoral immune response with intrathecal IgG and IgM class response and the polyspecific production of antibodies against a wide range of antigens (MRZ antibody response) further helps to differentiate childhood MS from ADEM as the main differential diagnostic challenge.

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Intrathecal synthesis of IgM in early multiple sclerosis

Cited by 5 publications

References 9 publications

Intrathecal IgM synthesis in pediatric MS is not a negative prognostic marker of disease progression: quantitative versus qualitative IgM analysis

Intrathecal IgM synthesis in pediatric MS is not a negative prognostic marker of disease progression: quantitative versus qualitative IgM analysis

Altered Cerebrospinal Fluid Concentrations of Hydrophobic and Hydrophilic Compounds in Early Stages of Multiple Sclerosis—Metabolic Profile Analyses

Clinical and neurochemical characteristics of pediatric multiple sclerosis – CSF analysis as knowledge base for differential diagnosis and pathophysiology

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