Intrathecal Ziconotide for Cancer Pain Relief: When, How and Why

Negri, Pasquale De; Tirri, Tiziana; Mameli, Sergio; Papa, Alfonso

doi:10.4172/2155-6148.1000227

Cited by 1 publication

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References 13 publications

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“…Cytotoxic effects have been observed in, among others, marine sponges and marine tunicates (Reyes et al, 2008;Susilowati et al, 2019). Several derivatives even have been used clinically as medicine, e.g., trabectedin isolated from the Caribbean tunicate for the treatment of advance soft tissue sarcoma (D'Incalci et al, 2014) and ziconotide and eribulin mesylate derived from the substances isolated from marine organisms (De Negri et al, 2012;Gomes et al, 2016). An example of organisms that are diverse in chemical compounds is cyanobacteria (Uzair et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The cytotoxic activities of the ethyl acetate and butanol crude extracts of marine cyanobacteria collected from Udar Island, Malaysia

Krisridwany¹,

Okino²

2020

Pharmaciana

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The ocean is abundant in organisms beneficial to living beings, including cyanobacteria that are widely studied for their bioactive compounds. This research was conducted to observe the compounds and concomitant cytotoxic activities of cyanobacteria in Udar Island waters, Sabah, Malaysia, against cancer cells. The samples were identified by the 16S DNA method, and a phylogenetic tree was built to check similarities in the genus. The samples were extracted using ethyl acetate and butanol. Afterward, the compounds were determined by Liquid Chromatography-Mass Spectrometry (LCMS), while the cytotoxicity activities were examined by the MTT assay. Several known compounds in ethyl acetate crude extract, such as several types of Apratoxins, and possible new compounds were observed. The compounds examined were mainly peptide. The crude ethyl acetate extracts of Moorea sp. in Udar Island waters were found to contain cytotoxic compounds, with the IC 50 value of 0.072 µg/mL against the MCF-7 breast cancer cell lines, that were more potent compared to the butanol crude extract, whose IC 50 was 2.031 µg/mL. Further isolation and cytotoxic tests are necessary to confirm which compounds are responsible as cytotoxic agents. This finding provides an opportunity for the discovery of anticancer compounds from marine cyanobacteria.

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