Intrathoracic Castleman disease

Biçakçioğlu, Pınar; Gülhan, Selim Şakir Erkmen; Acar, Leyla Nesrin; Agackiran, Yetkin; Özkara, Şeref; Kaya, Sadi; Karaoğlanoğlu, Nurettin

doi:10.3906/sag-1304-38

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…HV-MCD is a relatively rare clinical type, especially those cases with pulmonary involvement, and case has been reported in the literature mentioned the details of respiratory lesion was rare [2] so far. However, the details of pulmonary involvement were not descripted in those reported cases.…”

Section: Discussionmentioning

confidence: 99%

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WITHDRAWN: Lung Involvement Multicentric Castleman of Hyaline-vascular Variant: 3 cases

Cen¹,

Chen

Zeng

et al. 2021

Preprint

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BackgroundCastleman disease is clinically divided into unicentric Castleman disease (UCD), with hyaline-vascular Variant (HV) as major pathological pattern, and multicentric Castleman disease (MCD), with plasma cell type (PC) most commonly. Lung involvement is a serious complication of CD and usually leads to death.MethodWe retrospectively analyzed the medical records of 3 patients admitted to The First Affiliated Hospital of Guangxi Medical University during January 1, 2007 to September 30, 2020.Result2 male and 1 female with age ranging from 16 years old to 63 years old were admitted. The involved areas varied a lot. Respiratory symptoms were seen in 3 cases, along with fever, weight loss and splenomegaly. Dry and wet rales were found in all patients. All patients had hypoxemia and obstructive ventilation dysfunction. Computed tomography (CT) mainly showed bronchiectasis and mediastinal lymph node enlargement. All 3 cases were complicated with PNP. 1 case failed chemotherapy after local mass excision, 1 case remitted after chemotherapy but the lung lesion was irreversible, and 1 case was untreated and soon die of respiratory failure.ConclusionCases of HV-MCD with pulmonary affected were characterized by small airway lesions and poor prognosis. Respiratory symptoms along with systemic symptoms were common.

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Section: Discussionmentioning

confidence: 99%

“…4 cases of HV-MCD involving the lungs were reported previously [2,29], but chest CT, blood gas analysis and lung function results were not described in detail. HV-MCD is a rare type of CD.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Lung Involvement Multicentric Castleman of Hyaline-vascular Variant: 3 cases

Cen¹,

Chen

Zeng

et al. 2021

Preprint

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“…However, in any case, the findings are not specific for CD, making it very difficult to reach the diagnosis by radiological findings alone. Moreover, from the reports so far, definitive diagnosis by preoperative biopsy seems difficult [9–12]. Similarly, the preoperative diagnosis of our case could not be made because of insufficient biopsy specimens for the pulmonary hilar mass.…”

Section: Case Presentationmentioning

confidence: 76%

“…They reported that disease progression was noted at four years after surgery in one patient and, in another patient, complete resection was performed eight years after an initial biopsy and observation following the onset of symptoms [2]. Moreover, Biçakçioğlu et al reported that 17 of the 19 CD cases, including seven cases in the pulmonary hilum, in which surgery was performed were localized, and that 15 cases in which complete resection was performed had no recurrence [12]. Therefore, the recommended treatment strategy for localized HV type CD is complete resection.…”

Section: Case Presentationmentioning

confidence: 99%

Tumor enucleation for Castleman’s disease in the pulmonary hilum: a case report

et al. 2019

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Background The development of Castleman’s disease in the pulmonary hilum is extremely rare. Although resection of only the lesion is sufficient because of its benign nature, lobectomy or more extensive procedures performed for the pulmonary hilar tumor have been reported. Case presentation The patient was a 15-year-old male with a tumor in the right pulmonary hilum. Endobronchial ultrasound-guided transbronchial needle aspiration was performed but no specific findings were obtained from the cytological and histological evaluation. 18F-fluorodeoxyglucose positron emission tomography showed moderate accumulation in the tumor, which suggested potential malignancy. Intraoperative frozen section diagnosis did not show any malignant findings. Thus, we performed only tumor enucleation without any lung resection. The pathological diagnosis was hyaline vascular type Castleman’s disease. No recurrence has been observed for seven years. Conclusion Because hyaline vascular type Castleman’s disease in solitary pulmonary hilar tumor is one of the benign diseases common in young people, intraoperative frozen section diagnosis is recommended to avoid unnecessary lung resection.

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“…2,3 However, because of local infiltration and excessive vascularisation, surgery is often associated with severe haemorrhage or a failure to achieve complete resection. 4,5 Here, we describe a case of rapid recovery from the surgical resection of giant mediastinal lymph node hyperplasia.…”

Section: Introductionmentioning

confidence: 98%

A multidisciplinary collaborative model based on single-port thoracoscopy for the treatment of giant mediastinal lymph node hyperplasia: a case report

Liu

Zhu

et al. 2021

J Int Med Res

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Mediastinal unicentric Castleman disease (UCD) frequently manifests as a hyper-enhancing lymph node mass and is often surgically curable. However, because of excessive vascularisation and adhesion to important surrounding structures, surgery is often associated with severe haemorrhage that is often difficult to control thoracoscopically. Therefore, thoracotomy is often preferred, which increases the trauma to the patient and affects postoperative recovery. Here, we describe the case of a 30-year-old male patient with a large upper mediastinal lymph node (7 × 5 × 4 cm) that was compressing his superior vena cava. The distribution of nutritive arteries of the mass was analysed in detail, and the main branches were embolised prior to surgery. With the assistance of preoperative isovolumetric haemodilution, we achieved complete resection through single-port thoracoscopy, with only minor haemorrhage, which enabled the patient to recover rapidly. This multidisciplinary collaborative model, based on single-port thoracoscopic surgery, may be of wide practical use for the treatment of mediastinal UCD.

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Intrathoracic Castleman disease

Cited by 7 publications

References 26 publications

WITHDRAWN: Lung Involvement Multicentric Castleman of Hyaline-vascular Variant: 3 cases

WITHDRAWN: Lung Involvement Multicentric Castleman of Hyaline-vascular Variant: 3 cases

Tumor enucleation for Castleman’s disease in the pulmonary hilum: a case report

A multidisciplinary collaborative model based on single-port thoracoscopy for the treatment of giant mediastinal lymph node hyperplasia: a case report

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