Intrathoracic Myxosarcoma in a Dog

Sommerey, C.-C.; Borgeat, Kieran; Hetzel, Udo; Archer, Joy; Torrance, Andrew G.

doi:10.1016/j.jcpa.2012.01.006

Cited by 10 publications

(5 citation statements)

References 28 publications

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“…Epithelial-derived mucins are positive for both stains. 1,15 Our case exhibits a staining pattern that is consistent with mucin produced by mesenchymal cells. Mesotheliomas can also produce mucinous stroma and have been reported in equids; however, they have a more epithelioid morphology and exhibit positive immunoreactivity for cytokeratin in addition to positive immunoreactivity to vimentin.…”

supporting

confidence: 59%

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Metastatic myxosarcoma in a Quarter Horse gelding

et al. 2017

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A 22-y-old Quarter Horse gelding was presented to the University of Illinois Veterinary Teaching Hospital for evaluation of increased heart rate and mild colic signs. Rectal examination revealed a large left perirenal mass. Abdominal ultrasonography further confirmed this finding. Thoracic ultrasonography indicated multifocal irregularities on the pleural surface suggestive of consolidation and possibly masses in the lungs. The animal was euthanized. Autopsy findings included a large, firm, expansile, gelatinous retroperitoneal mass that surrounded both kidneys, as well as nodules with similar morphology in the lungs, liver, intestinal mesentery, cecum, and caudal mesenteric artery. Histologically, the masses were composed of neoplastic stellate-to-spindloid cells in abundant mucinous stroma. Neoplastic cells exhibited strong immunoreactivity for vimentin and were negative for pancytokeratin (A1/A3), CD3, CD20, melan A, and synaptophysin. Mucinous stroma was strongly positive with alcian blue and weakly positive with periodic acid-Schiff histochemical staining. These findings are consistent with metastatic myxosarcoma. Myxosarcoma is a rare neoplasm in horses, and metastasis to tissues other than sentinel lymph nodes has not been described previously to our knowledge.

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supporting

confidence: 59%

“…Previous publications document occurrence in the skin, mandible, heart, lungs, and abdominal peritoneum. 1,[5][6][7]14,15 Myxomas and myxosarcomas have been reported to affect both foals and adult horses. Myxomas are rare tumors in equid that have been reported to affect the bone and soft tissues of the head, the heart, and bronchi.…”

mentioning

confidence: 99%

Metastatic myxosarcoma in a Quarter Horse gelding

et al. 2017

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“…These include a visceral mast cell tumor associated with a peritoneal effusion in a dog, malignant melanoma associated with a pleural effusion in a cat, and myxosarcoma associated with pleural effusions (de Souza et al, 2001;Morges and Zaks, 2011;Riegel et al, 2008;Sommerey et al, 2012). These include a visceral mast cell tumor associated with a peritoneal effusion in a dog, malignant melanoma associated with a pleural effusion in a cat, and myxosarcoma associated with pleural effusions (de Souza et al, 2001;Morges and Zaks, 2011;Riegel et al, 2008;Sommerey et al, 2012).…”

Section: Other Neoplasmsmentioning

confidence: 99%

Body Cavity Fluids

Thompson¹,

Rebar²

2016

Canine and Feline Cytology

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“…Multinucleated giant cells (MGCs) are a prominent and common histological feature of many mesenchymal neoplasms of various domestic animals, including anaplastic sarcoma, 31 fibrosarcoma, 13 feline vaccine-associated sarcoma, 13,27 myxosaroma, 29 giant cell tumor of soft parts, 5 peripheral nerve sheath tumors, 7 perivascular wall tumors, 2 pleomorphic liposarcoma, 3 rhabdomyosarcoma, 25,31 skeletal and extraskeletal osteosarcoma, 17,31 giant cell glioblastoma, 12 osteoclastoma, 10 histiocytic sarcoma, 1,14,15,22 mast cell tumors, 28 extramedullary plasmacytoma, 21 and deciduosarcoma. 8 In contrast, MGCs have rarely been reported in epithelial neoplasms, such as anaplastic mammary carcinomas 9 and undifferentiated thyroid carcinomas.…”

mentioning

confidence: 99%

Giant Cell Sarcomas in Domestic Rabbits (Oryctolagus cuniculus)

Bertram

Garner²,

Reavill³

et al. 2020

Vet Pathol

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Multinucleated giant cells (MGCs) are a prominent histological feature of various mesenchymal neoplasms and are often considered a criterion of malignancy. Mesenchymal neoplasms with MGCs for which the cell lineage is unclear generally are referred to as giant cell sarcomas. Here we characterize the gross, histologic, and immunohistochemical features of 90 giant cell sarcomas in domestic pet rabbits. Based on the anatomic location and histologic and immunohistochemical findings, 18 cases were classified as histiocytic sarcomas (HS) and 72 cases as anaplastic sarcomas (AS). At postmortem examination, HS was either localized HS ( n = 7) always affecting the lungs, or disseminated HS ( n = 10) that affected the lungs ( n = 10), liver ( n = 6), kidneys ( n = 4), pleura ( n = 2), mediastinum ( n = 2), heart ( n = 4), skeletal muscle ( n = 1), adipose tissue ( n = 1), and lymph node ( n = 1). Additionally, one cecal biopsy was consistent with HS. Microscopically, HS were characterized by sheets of neoplastic polygonal to round cells that contained single to several, often greatly enlarged nuclei as well as abundant cytoplasm. HS were always positive for CD204 and always negative for SMA and desmin. In contrast, AS arose most commonly from the skin or subcutis ( n = 62) and rarely the skeletal muscle ( n = 8) or abdominal organs ( n = 2). In 29% of extra-abdominal AS, the tumor deeply invaded into surrounding connective tissue, skeletal muscle, tendons, and bone causing pathological fractures. Five of 9 postmortem cases metastasized to various organs often including the lungs. Microscopically, AS were characterized by sheets of spindle or pleomorphic cells admixed with variable numbers of MGCs. Immunohistochemically, AS were always negative for CD204 and often (71%) positive for SMA and/or desmin.

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Intrathoracic Myxosarcoma in a Dog

Cited by 10 publications

References 28 publications

Metastatic myxosarcoma in a Quarter Horse gelding

Metastatic myxosarcoma in a Quarter Horse gelding

Body Cavity Fluids

Giant Cell Sarcomas in Domestic Rabbits (Oryctolagus cuniculus)

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