Intrathyroid injection of dexamethasone inhibits Th2 cells in Graves’ disease

He, Ke; Peng, Jiang; Liu, Bing-li; Liu, Xiaomei; Mao, Xiao‐Ming; Hu, Yun

doi:10.20945/2359-3997000000244

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…Similar to other autoimmune diseases, the pathogenesis of GD is related to the imbalance of related cytokines in the body [7]. e CXC chemokine 13 (CXCL-13) is a proin ammatory chemokine derived from stromal cells, which has a strong proinammatory capacity and can bind to its receptor CXCR-5, playing an important role in the regulation, aggregation, and migration of B lymphocytes proliferation and di erentiation [8,9]. Retinol-binding protein-4 (RBP-4) is a transporter protein distributed in blood, urine, and other body fluids, which plays an important role in fat metabolism.…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of CXCL-13, RBP-4, and IL-6, and Correlation Analysis of Patients with Graves’ Disease

Sun

Huang

et al. 2022

Emergency Medicine International

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Objective. To investigate the serum levels of CXC chemokine 13 (CXCL-13), retinol binding protein-4 (RBP-4), and interleukin 6 (IL-6) in patients with Graves’ disease (GD). The correlation between CXCL-13, RBP-4, and IL-6 levels and the basal metabolic rate (BMR) was analyzed. Methods. 118 GD patients diagnosed in our hospital were selected as the observation group from March 2017 to December 2018. According to the measured BMR value, 118 GD patients were divided into the mild group (n = 39), the moderate group (n = 47), and the severe group (n = 32), three subgroups. 60 healthy subjects were selected as the control group. The serum levels of CXCL-13, RBP-4, IL-6, TSH, FT3, and FT4 in every group were measured. Pearson correlation analysis was used to observe the correlation of serum CXCL-13, RBP-4, and IL-6 levels with TSH, FT3, FT4, and BMR. Results. The levels of serum CXCL-13, RBP-4, and IL-6 in the observation group were higher than those of the control group, and the differences were statistically significant ( P < 0.05 ). The levels of serum CXCL-13, RBP-4, and IL-6 in the moderate and severe groups were higher than those in the mild group, and the differences were statistically significant ( P < 0.05 ). The levels of serum CXCL-13, RBP-4, and IL-6 in the severe group were higher than those in the moderate group, and the differences were statistically significant ( P < 0.05 ). Pearson correlation analysis showed that the serum levels of CXCL-13, RBP-4, and IL-6 in GD patients were negatively correlated with TSH levels and positively correlated with FT3 and FT4 levels. Serum CXCL-13, RBP-4, and IL-6 levels in GD patients were positively correlated with BMR (r = 0.915, r = 0.942, r = 0.926, P < 0.001 ). Conclusion. Serum CXCL-13, RBP-4, and IL-6 levels are elevated in patients with GD, and with the aggravation of the disease, the serum CXCL-13, RBP-4, and IL-6 levels also increase, showing a positive correlation, which can be used as indicators to reflect the degree of GD.

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Section: Introductionmentioning

confidence: 99%

Serum Levels of CXCL-13, RBP-4, and IL-6, and Correlation Analysis of Patients with Graves’ Disease

Sun

Huang

et al. 2022

Emergency Medicine International

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“…This study was remarkable for the histological finding that showed an improvement in histological picture even on the day following injection, which showed a reformation of follicular structure and a reduction in epithelial cells swelling [14]. ISI was proved to inhibit Th2 cells in Graves` disease [15], which may also play a role in SAT pathogenesis [16]. Five cases of painful Hashimoto thyroiditis were successfully treated with injection of triamcinolone [17,18].…”

Section: Side Effectsmentioning

confidence: 99%

Painful Subacute Thyroiditis Treatment Approach

et al. 2021

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The aim: The study was aimed to compare the efficiency of intrathyroid steroid injection to oral steroid intake in patients with subacute thyroiditis. Materials and methods: 32 patients with subacute thyroiditis with insufficient result from NSAIDs treatment were randomly divided into two groups. The 1st group received two intrathyroid steroid injections, the 2nd group received oral prednisone. The results of the treatment were evaluated via ultrasound and evaluation of ESR and CRP at 0, 2, 4, 8 and 16 weeks of treatment. Results: Patients of the 1st group showed much faster result at the ultrasound compared to the 2nd group: mean decrease in hypoechogenity area 44,42% vs 16,35% at week 2, p < 0,001; 93,29% vs 75,98% at week 4, p < 0,001; 97,8% vs 95,24% at week 8, p = 0,4; mean decrease in ESR 66,34% vs 51,92% at week 2, p = 0,023; 84,43% vs 74,94% at week 4, p = 0,023; mean decrease in CRP 26,53% vs 20,77% at week 2, p = 0,024, 33,77% vs 29,98%, at week 4, p = 0,026. No side effects were noted during the treatment of patients of the 1st group. Conclusions: Compared to oral steroid intake intrathyroid steroid injection is faster, safer and generally better tolerated by patients.

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“…Dexamethasone (DEX), a synthetic glucocorticoid, is widely used in various clinical departments, including endocrinology, oncology, and respiratory medicine (9)(10)(11). Furthermore, glucocorticoids exert analgesic effects by reducing the secretion of bradykinin and neuropeptides tissues, as well as inhibiting pain signaling in the noxious C-fibers (12,13).…”

Section: Introductionmentioning

confidence: 99%

Experimental study of dexamethasone-loaded hollow hydroxyapatite microspheres applied to direct pulp capping of rat molars

et al. 2023

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BackgroundDexamethasone (DEX) exerts anti-inflammatory and osteogenic effects. Hydroxyapatite is commonly used in bone repair due to its osteoconductivity, osseointegration, and osteogenesis induction. Hollow hydroxyapatite (HHAM) is often used as a drug carrier.ObjectiveThis study aimed to investigate the histological responses of exposed dental pulp when dexamethasone-loaded nanohydroxyapatite microspheres (DHHAM) were used as a direct capping agent.MethodsCavities were created in the left maxillary first molar of Wistar rats and filled with Dycal, HHAM, and DHHAM. No drug was administered to the control group. The rats were sacrificed at 1, 2, and 4 weeks after the procedure. The molars were extracted for fixation, demineralization, dehydration, embedding, and sectioning. H&E staining was performed to detect the formation of reparative dentin. H&E and CD45 immunohistochemical staining were performed to detect pulp inflammation. Immunohistochemical staining was performed to assess the expressions of dentin matrix protein 1 (DMP-1), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β.ResultsThe results of H&E and CD45 immunohistochemical staining showed that the degree of inflammation in the DHHAM group was less than that in the Control and HHAM groups at 1, 2, and 4 weeks after capping of the rat molar teeth (p<0.01). The H&E staining showed that the percentage of reparative dentin formed in the DHHAM group was higher than that in the Control, HHAM (p<0.001), and Dycal groups (p<0.01) at 1 and 2 weeks, and was significantly higher than that in the Control group (p<0.001) and the HHAM group (p<0.01) at 4 weeks. The immunohistochemical staining showed a lower range and intensity of expression of IL-1β, IL-6, and TNF-α and high expression levels of DMP-1 in the DHHAM group at 1, 2, and 4 weeks after pulp capping relative to the Control group.ConclusionsDHHAM significantly inhibited the progression of inflammation and promoted reparative dentin formation.

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Intrathyroid injection of dexamethasone inhibits Th2 cells in Graves’ disease

Cited by 7 publications

References 34 publications

Serum Levels of CXCL-13, RBP-4, and IL-6, and Correlation Analysis of Patients with Graves’ Disease

Serum Levels of CXCL-13, RBP-4, and IL-6, and Correlation Analysis of Patients with Graves’ Disease

Painful Subacute Thyroiditis Treatment Approach

Experimental study of dexamethasone-loaded hollow hydroxyapatite microspheres applied to direct pulp capping of rat molars

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