Intrathyroidal epithelial thymoma (ITET)/carcinoma showing thymus‐like differentiation (CASTLE) exhibits CD5 immunoreactivity: new evidence for thymic differentiation

Dorfman, David M.; Shahsafaei, Aliakbar; Miyauchi, Akira

doi:10.1046/j.1365-2559.1998.00318.x

Cited by 89 publications

(63 citation statements)

References 13 publications

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“…CASTLE is a rare neoplasm which exhibits slow growth and a favourable prognosis [28]. These tumors are immunoreactive with CD5 [29]. In the present study, none of the three cases were immunoreactive with CD5 in contrast to CASTLE.…”

Section: Discussioncontrasting

confidence: 46%

Primary Squamous Cell Carcinoma of the Thyroid: Report of Three Cases

et al. 2008

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Abstract. We report three cases of squamous cell carcinoma of the thyroid, which is an unusual malignant tumor that needs to be distinguished from other thyroid pathologies due to its aggressive behaviour. Three men, with an average of 63 years old, presented with progressive enlargement in the neck, hoarse voice or weight loss. Physical and radiological examinations revealed clues where malignancy was suspected and surgical resections were performed. Histopathological examination of the specimens was diagnosed as squamous cell carcinoma. Proper workup excluded the possibility of any primary site of SCC other than the thyroid. All patients died within 5 months. Adjuvant therapy evaluation is still inconclusive. Complete surgical resection still remains the primary choice for cure. We believe that radical resection with clear surgical margins followed by adjuvant chemo-radiation therapy is a curative strategy for achieving any chance of long-term survival.

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Section: Discussioncontrasting

confidence: 46%

Primary Squamous Cell Carcinoma of the Thyroid: Report of Three Cases

et al. 2008

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“…The majority of thymomas or other malignancies are CD5 negative. 4,10,16 It is reported that expression of high molecular weight keratin (HMWCK), carcinoembryonic antigen (CEA), and p63 in CASTLE are evidence of thymic origin and are useful diagnostic markers to distinguish thyroid CASTLE from other thyroid neoplasms. 13 Ito et al reported a sensitivity and a specificity of 82% and 100%, respectively, for CD5 positive for the diagnosis of CASTLE.…”

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confidence: 99%

Clinical Analysis of Thyroid Carcinoma Showing Thymus-Like Differentiation: Report of 8 Cases

Liu

Teng

Sun

et al. 2013

International Surgery

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Thyroid carcinoma showing thymus-like differentiation (CASTLE) is a kind of rare neoplasm of the thyroid gland. Because thyroid CASTLE is rare and difficult to diagnose, its clinicopathologic features have not been well defined, and no universally accepted treatment recommendation is available. We analyzed retrospectively the clinicopathologic data of 8 patients with thyroid CASTLE who underwent surgery and radiotherapy at the Shengjing Hospital of China Medical University between December 2008 and June 2012. All patients accepted radical surgery. All patients accepted postoperative radiotherapy, except one 79-year-old patient. There was no evidence of recurrence or metastasis during the follow-up period. The pattern of immunohistochemical staining was similar to that of thymic carcinoma. Six of 8 CASTLE cases expressed CD5. All 8 CASTLE patients were negatively expressed in thyroglobulin, thyroid transcription factor 1, and calcitonin. Patients with thyroid CASTLE have good outcomes after radical resection and postoperative radiotherapy. Positive CD5 immunoreactivity can contribute to diagnosis of this disease.

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“…Friedman et al reported on fine-needle aspiration of a thymoma mimicking lymphoblastic lymphoma [11]. It has been reported a few times that fine-needle aspi- ration of an ectopic cervical thymoma mimicked a thyroid lymphoid tumor, such as Hashimoto's thyroiditis or malignant lymphoma [12][13][14]. An ectopic thymoma shows the same histological features as mediastinal thymoma.…”

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confidence: 99%

A Case of Malignant Thymoma Mimicking Thyroid Carcinoma: A Pitfall in Fine-needle Aspiration

et al. 2004

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Abstract. A case of malignant thymoma presenting as an anterior neck mass is reported. The tumor extended from the thyroid gland to the superior mediastinum. It did not accumulate Tc-99m pertechnetate, but continued to accumulate Tl-201 at the late phase. A fine-needle aspiration cytology from the tumor showed tight clusters of epithelial cells with crowded ovoid nuclei. The tumor was initially diagnosed as thyroid carcinoma, clinically and cytologically. A thymoma with a dominant epithelial component has to be considered in the differential diagnosis of a suspected papillary carcinoma of the thyroid.

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Intrathyroidal epithelial thymoma (ITET)/carcinoma showing thymus‐like differentiation (CASTLE) exhibits CD5 immunoreactivity: new evidence for thymic differentiation

Abstract: CD5 immunoreactivity in ITET/CASTLE is new evidence in support of thymic differentiation in this neoplasm.

Cited by 89 publications

References 13 publications

Primary Squamous Cell Carcinoma of the Thyroid: Report of Three Cases

Primary Squamous Cell Carcinoma of the Thyroid: Report of Three Cases

Clinical Analysis of Thyroid Carcinoma Showing Thymus-Like Differentiation: Report of 8 Cases

A Case of Malignant Thymoma Mimicking Thyroid Carcinoma: A Pitfall in Fine-needle Aspiration

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