Intrathyroidal hematopoiesis: a rare histological finding in an otherwise healthy patient and review of the literature

Westhoff, Christina C.; Karakas, Elias; Dietz, Carsten; Barth, Peter

doi:10.1007/s00423-008-0299-1

Cited by 12 publications

(9 citation statements)

References 10 publications

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“…Clotting abnormalities were not detected, neither anemia nor hematological disease. Of interest would be the relatively increased frequency of reported cases with intrathyroid hematopoiesis (associated with myelofibrosis or anemia or not) as compared to that of thyroid bone metaplasia [ 10 ]. The extensive study of the quasi-totality of thyroidectomy specimens revealed numerous ossification foci (more than 10) in two of the cases, while hematopoietic elements without bone formation lacked.…”

Section: Discussionmentioning

confidence: 99%

“…Thyroid HBF, frequently designated as bone metaplasia, occurs rarely in the thyroid, being reported both in goiter and in tumors such as adenomas and carcinosarcomas [ 1 – 10 ]. To our knowledge, seven cases of thyroid sporadic goiter with complete, adult HBF are reported in the English medical literature [ 2 , 4 , 7 – 10 ]. Here we report five additional cases of complete, adult HBF occurring in the context of sporadic thyroid nodular goiter.…”

Section: Introductionmentioning

confidence: 99%

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Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation

Dumuis-Gimenez

Bendib²,

Anagnostis³

2015

Case Reports in Endocrinology

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Thyroid heterotopic bone formation (HBF) in goiter is a rare finding. Five thyroid resection specimens were analyzed for HBF. The results were correlated with clinicomorphological features. All patients were women (33–82 years). The preoperative diagnosis was thyroid goiter or nodule. Treatment consisted in thyroidectomy and lobectomy (3 and 2, resp.). Microscopy showed sporadic nodular goiter. Malformative blood vessels and vascular calcifications were seen in intra- and extrathyroid location (5 and 3, resp.). The number and size of HBFs (total: 28) ranged between 1 and 23/thyroid gland (one bilateral) and 1 and 10 mm, respectively. Twelve HBFs were in contact with the thyroid capsule. Most were extranodular (21, versus 6 intranodular). The medical history was positive for dyslipidemia, hyperglycemia, renal dysfunction, and hyperuricemia (2, 3, and 3 cases and 1 case, resp.) without any parathyroid abnormality. In conclusion, thyroid HBF may be characterized by subcapsular or extranodular location, various size (usually ≥2 mm), and vascular calcifications and malformations. Features of metabolic syndrome and renal dysfunction may be present, but their exact role in the pathogenesis of HBFs remains to be elucidated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation

Dumuis-Gimenez

Bendib²,

Anagnostis³

2015

Case Reports in Endocrinology

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“…Nodular hyperplasia has the most reported cases of findings of these pathologic processes [2], [3], [4], [5], [6], [7], [8]. The reported cases had varied combinations of these pathologic findings (see Table 1), with most suggesting the aid of bone morphogenic proteins (BMPs) in OM and EBF.…”

Section: Discussionmentioning

confidence: 99%

“…These nodules can undergo hemorrhagic, cystic, and fibrotic changes, and rarely will calcify or ossify. Cases of multinodular goiter, thyroid hyperplasia, follicular adenoma, papillary thyroid carcinoma, and anaplastic thyroid carcinoma have been reported with histopathologic findings of osseous metaplasia (OM), bone marrow metaplasia (BMM), ectopic bone formation (EBF), ossification, and extramedullary hematopoiesis (EMH) [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]. These cases are exceedingly rare.…”

Section: Introductionmentioning

confidence: 99%

A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid

Aurora

Hashmi

Misra

et al. 2017

International Journal of Surgery Case Reports

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HighlightsOsseous metaplasia and bone formation may be seen in a broad spectrum of diseases involving the thyroid gland especially in malignant neoplasms of the thyroid gland.However, this differentiation is not unique to malignant neoplasms. It may also be encountered in follicular adenomas of the thyroid.Awareness of thyroid nodules undergoing hemorrhagic, cystic, and fibrotic changes, as well as calcification and ossification is paramount in proper diagnosis and treatment of these pathologies.Particularly, patient’s history, associated risk factors and clinical presentation are the most important factors to consider in clinical differentiation of malignant and benign diagnoses.All ossifications in a thyroid nodule should be considered suspicious for malignancy until proven otherwise.

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“…Thyroid diseases are benign or malignant disorders that affect the structure and function of the thyroid gland [5]. Thyroid histopathology typically shows hemorrhage, fibrosis, calcification, and cystic changes [6].…”

Section: Discussionmentioning

confidence: 99%

Extensive Osseous Metaplasia With Mature Bone Formation of Thyroid Gland

Basbug

2012

J Endocrinol Metab

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Multinodular goiter is a disease frequently encountered in endocrine surgery. Although histopathological examination of the thyroid gland often reveals fibrosis, calcification, degenerative and cystic changes, and hemorrhagic tissue, osseous metaplasia is a very rare phenomenon in the thyroid gland. We present a case of multinodular goiter with histological osseous metaplasia and mature bone formation in a 65 years old female patient.

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Intrathyroidal hematopoiesis: a rare histological finding in an otherwise healthy patient and review of the literature

Cited by 12 publications

References 10 publications

Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation

Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation

A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid

Extensive Osseous Metaplasia With Mature Bone Formation of Thyroid Gland

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