Intrathyroidal parathyroid carcinoma in a pediatric patient

Herrera-Hernandez, Alvaro A.; Aranda-Valderrama, Paola; Díaz-Pérez, Julio A.; Herrera, Laura Viviana

doi:10.1007/s00383-011-2904-6

Cited by 20 publications

(9 citation statements)

References 26 publications

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“…Herrera-Hernández et al described the first case of intrathyroidal parathyroid carcinoma occurring in a pediatric patient [12]. Sestamibi scan was helpful in three cases in localizing the parathyroid gland before surgical exploration [8, 10, 12]. Findings of lymphocytic thyroiditis, similar to our case, and a microscopic focus of papillary thyroid carcinoma were detected in a case by Schmidt et al [9].…”

Section: Discussionsupporting

confidence: 70%

“…Other presentations of intrathyroidal parathyroid carcinoma have included goiter and symptoms relating to hypercalcemia [9–13]. Herrera-Hernández et al described the first case of intrathyroidal parathyroid carcinoma occurring in a pediatric patient [12]. Sestamibi scan was helpful in three cases in localizing the parathyroid gland before surgical exploration [8, 10, 12].…”

Section: Discussionmentioning

confidence: 99%

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Intrathyroidal Parathyroid Carcinoma: Report of an Unusual Case and Review of the Literature

Duckworth

Winter

Vaysberg

et al. 2013

Case Reports in Pathology

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Intrathyroidal parathyroid carcinoma is an exceedingly rare cause of primary hyperparathyroidism. A 51-year-old African American female presented with goiter, hyperparathyroidism, and symptomatic hypercalcemia. Sestamibi scan revealed diffuse activity within an enlarged thyroid gland with uptake in the right thyroid lobe suggestive of hyperfunctioning parathyroid tissue. The patient underwent thyroidectomy and parathyroidectomy. At exploration, a 2.0 cm nodule in the usual location of the right inferior parathyroid was sent for intraoperative frozen consultation, which revealed only ectopic thyroid tissue. No parathyroid glands were identified grossly on the external aspect of the thyroid. Interestingly, postoperative parathyroid hormone levels normalized after removal of the thyroid gland. Examination of the thyroidectomy specimen revealed a 1.4 cm parathyroid nodule located within the parenchyma of the right superior thyroid, with capsular and vascular invasion and local infiltration into surrounding thyroid tissue. We present only the eighth reported case of intrathyroidal parathyroid carcinoma and review the literature.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Intrathyroidal Parathyroid Carcinoma: Report of an Unusual Case and Review of the Literature

Duckworth

Winter

Vaysberg

et al. 2013

Case Reports in Pathology

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“…A review of the literature identified only 12 other pediatric cases (Supplementary Table S1). Demographic details appear to match those of our patient with the median age of presentation reported to be 13 years of age and a near 1:1 male‐to‐female ratio. Of the eight cases in the literature with follow‐up and relapse data, 3 patients appear to have relapsed with pulmonary metastases within a timeframe of 6 months to 5 years.…”

Section: Discussionsupporting

confidence: 81%

“…calcium in our patient were similar to other cases of parathyroid carcinoma described in the literature. (23,26) Nonetheless, we cannot exclude the possibility that denosumab may have contributed to the need for i.v. calcium support.…”

Section: Discussionmentioning

confidence: 99%

Severe Primary Hyperparathyroidism Caused by Parathyroid Carcinoma in a 13‐Year‐Old Child; Novel Findings From HRpQCT

et al. 2020

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Primary hyperparathyroidism is a condition that occurs infrequently in children. Parathyroid carcinoma, as the underlying cause of hyperparathyroidism in this age group, is extraordinarily rare, with only a few cases reported in the literature. We present a 13‐year‐old boy with musculoskeletal pain who was found to have brown tumors from primary hyperparathyroidism caused by parafibromin‐immunodeficient parathyroid carcinoma. Our patient had no clinical, biochemical, or radiographic evidence of pituitary adenomas, pancreatic tumors, thyroid tumors, pheochromocytoma, jaw tumors, renal abnormalities, or testicular lesions. Germline testing for AP2S1, CASR, CDC73/HRPT2, CDKN1B, GNA11, MEN1, PTH1R, RET, and the GCM2 gene showed no pathological variants, and a microarray of CDC73/HRPT2 did not reveal deletion or duplication. He was managed with i.v. fluids, calcitonin, pamidronate, and denosumab prior to surgery to stabilize hypercalcemia. After removal of a single parathyroid tumor, he developed severe hungry bone syndrome and required 3 weeks of continuous i.v. calcium infusion, in addition to oral calcium and activated vitamin D. Histopathological examination identified an angioinvasive parathyroid carcinoma with global loss of parafibromin (protein encoded by CDC73/HRPT2).HRpQCT and DXA studies were obtained prior to surgery and 18‐months postsurgery. HRpQCT showed a resolution of osteolytic lesions combined with structural improvement of cortical porosity and an increase in both cortical thickness and density compared with levels prior to treatment. These findings highlight the added value of HRpQCT in primary hyperparathyroidism. In addition to our case, we have provided a review of the published cases of parathyroid cancer in children. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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“…16) To the best of our knowledge, only 14 cases of intrathyroidal parathyroid carcinoma have been reported (Table 1). [17][18][19][20][21][22][23][24][25][26][27][28][29][30] All of these cases presented with hypercalcemia with or without a neck mass. The PTH level was higher than 200 pg/mL in all cases, and some of them were higher than 1000 pg/mL.…”

Section: Discussionmentioning

confidence: 99%

Intrathyroidal Parathyroid Carcinoma in Chronic Kidney Disease: A Case Report and Review of Literature

Kim¹,

Song²,

Tae³

et al. 2019

Korean J Otorhinolaryngol-Head Neck Surg

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When parathyroid carcinoma occurs in the thyroid gland, it is very difficult to diagnose before surgery because imaging studies and aspiration cytology cannot distinguish parathyroid carcinoma from thyroid nodule or benign parathyroid disease. A 53-year-old male was referred to our hospital for assessment of hypercalcemia. He had suffered from chronic kidney disease for 13 years. A 2.5×1.5 cm hypoechoic nodule was noted in the left thyroid gland on ultrasonography, and it showed increased uptake on the sestamibi scan. Fine needle aspiration biopsy revealed it to be a parathyroid lesion, which was confirmed by surgery as parathyroid carcinoma completely surrounded by normal thyroid parenchyme. Because ultrasonography and aspiration cytology have only a limited role in distinguishing parathyroid carcinoma from thyroid neoplasm, suspicion of parathyroid carcinoma before or during surgery through careful examination can lead to complete resection at the initial surgery. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Intrathyroidal parathyroid carcinoma in a pediatric patient

Cited by 20 publications

References 26 publications

Intrathyroidal Parathyroid Carcinoma: Report of an Unusual Case and Review of the Literature

Intrathyroidal Parathyroid Carcinoma: Report of an Unusual Case and Review of the Literature

Severe Primary Hyperparathyroidism Caused by Parathyroid Carcinoma in a 13‐Year‐Old Child; Novel Findings From HRpQCT

Intrathyroidal Parathyroid Carcinoma in Chronic Kidney Disease: A Case Report and Review of Literature

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