Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt/β-catenin signaling pathway in mice

Li, Xuran; Zhang, Tongtong; Lv, Wenting; Wang, Hui; Chen, Haoran; Xu, Qinghua; Cai, Hourong; Dai, Jinghong

doi:10.1016/j.ecoenv.2022.113238

Cited by 88 publications

(33 citation statements)

References 35 publications

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“…Granulosa cells are the essential somatic cells of the ovary responsible for normal ovarian development and maturation and play a significant role in folliculogenesis ( 102 ). In addition, PS-MPs also induce fibrosis of the ovary through activation of the Wnt/β-Catenin signaling pathway and apoptosis of granulosa cells by oxidative stress, reducing normal ovarian reserve capacity in rats ( 99 , 103 ). The wnt/β-Catenin signaling pathway is essential for maintaining tissue homeostasis and regulating embryonic maturation, cell proliferation, and apoptosis ( 104 ).…”

Section: Effects Of Mps Nps and Their Associated Chemicals On The Fem...mentioning

confidence: 99%

A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals

et al. 2023

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Over the years, the vaste expansion of plastic manufacturing has dramatically increased the environmental impact of microplastics [MPs] and nanoplastics [NPs], making them a threat to marine and terrestrial biota because they contain endocrine disrupting chemicals [EDCs] and other harmful compounds. MPs and NPs have deleteriouse impacts on mammalian endocrine components such as hypothalamus, pituitary, thyroid, adrenal, testes, and ovaries. MPs and NPs absorb and act as a transport medium for harmful chemicals such as bisphenols, phthalates, polybrominated diphenyl ether, polychlorinated biphenyl ether, organotin, perfluorinated compounds, dioxins, polycyclic aromatic hydrocarbons, organic contaminants, and heavy metals, which are commonly used as additives in plastic production. As the EDCs are not covalently bonded to plastics, they can easily leach into milk, water, and other liquids affecting the endocrine system of mammals upon exposure. The toxicity induced by MPs and NPs is size-dependent, as smaller particles have better absorption capacity and larger surface area, releasing more EDC and toxic chemicals. Various EDCs contained or carried by MPs and NPs share structural similarities with specific hormone receptors; hence they interfere with normal hormone receptors, altering the hormonal action of the endocrine glands. This review demonstrates size-dependent MPs’ bioaccumulation, distribution, and translocation with potential hazards to the endocrine gland. We reviewed that MPs and NPs disrupt hypothalamic-pituitary axes, including the hypothalamic-pituitary-thyroid/adrenal/testicular/ovarian axis leading to oxidative stress, reproductive toxicity, neurotoxicity, cytotoxicity, developmental abnormalities, decreased sperm quality, and immunotoxicity. The direct consequences of MPs and NPs on the thyroid, testis, and ovaries are documented. Still, studies need to be carried out to identify the direct effects of MPs and NPs on the hypothalamus, pituitary, and adrenal glands.

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Section: Effects Of Mps Nps and Their Associated Chemicals On The Fem...mentioning

confidence: 99%

A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals

et al. 2023

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“…Experiments with mice revealed that molecular or higher-level alterations arise after prolonged exposure to MPs. 159 The damage that occurs in organs and tissues depends on the dose exposed, 160 and plastic particles detected in the lungs not only comprise the range of MPs since smaller plastic particles (100 nm–1 μm) have been observed. 161 Likewise, MPs' harmful effects on the respiratory system are exacerbated in mice with pre-existing respiratory diseases.…”

Section: Toxicity Of Mpsmentioning

confidence: 99%

Atmospheric microplastics: exposure, toxicity, and detrimental health effects

et al. 2023

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“…Indicatively, MPs have been found in the lungs of a human cadaver, where particle size distribution affects tissue accumulation kinetics and distribution patterns (Pauly et al, 1998;Amato-Lourenço et al, 2021). Endocytosis by epithelial layer cells causes MP retention in the lungs, where they cause intensive oxidative stress (Liu et al, 2021a;Li et al, 2022b). Phagocytosis for MPs of sizes greater than 0.5 μm leads to accumulation in the liver and spleen, which induces acute inflammation and apoptosis (Tang et al, 2022).…”

Section: Effects On Ecology and Human Healthmentioning

confidence: 99%

The Current Status of Atmospheric Micro/Nanoplastics Research: Characterization, Analytical Methods, Fate, and Human Health Risk

Kung

Cheruiyot

et al. 2023

Aerosol Air Qual. Res.

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Atmospheric plastic debris (microplastic and nanoplastic) research is comparatively little than in aquatic and terrestrial environments. Nonetheless, the research is important in understanding the risk and fate of these contaminants in the total environment. Generally, the research is limited by a lack of consensus on the characterization of plastic debris and the standardization of sampling and analysis A C C E P T E D MA N U S C R I P T 2 protocols. These limitations make it difficult to compare results from studies. In response, criteria for defining plastic debris beyond size characterization have been proposed to include polymeric composition, solubility, physical state, shape, color, and origin. There are also emerging techniques, such as Py-GC/MS, which can measure smaller particles in the nanoscale range, and TGA-FTIR-GC/MS, which can accurately identify more polymers. The identification of microplastics and nanoplastics sources and formation processes is challenging. Since most polymers are inert, the adverse health risks include endocytosis and accumulation in the liver and spleen. However, most of the toxic effects of these contaminants are related to surface-bound compounds, including heavy metals and persistent organic pollutants. Some polymers, such as expanded polystyrene, decompose to form carcinogens. This paper offers an overview of the current knowledge on plastic debris in the atmosphere and will be useful to researchers interested in this field.

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Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt/β-catenin signaling pathway in mice

Cited by 88 publications

References 35 publications

A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals

A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals

Atmospheric microplastics: exposure, toxicity, and detrimental health effects

The Current Status of Atmospheric Micro/Nanoplastics Research: Characterization, Analytical Methods, Fate, and Human Health Risk

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