Intratumor heterogeneity is biomarker specific and challenges the association with heterogeneity in multimodal functional imaging in head and neck squamous cell carcinoma

Rasmussen, Jacob; Olin, Anders B.; Lelkaitis, Giedrius; Hansen, Adam E.; Andersen, Flemming; Johannesen, Helle Hjorth; Kjær, Andreas; Fischer, Barbara; Specht, Lena; Bentzen, Søren M.; Buchwald, Christian von; Wessel, Irene; Vogelius, I.R.

doi:10.1016/j.ejrad.2021.109668

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…The presented SADT delineated the VTV based on the underlying assumption that hyperintense areas on high b-value DWI correspond to high cellularity. This assumption has been widely supported [26] , although a lower degree of correlation has been observed in patients [27] . A higher correlation might have been found if delineations were better confined to viable tumour sub-regions, such as the VTV.…”

Section: Discussionmentioning

confidence: 85%

Robust extraction of biological information from diffusion-weighted magnetic resonance imaging during radiotherapy using semi-automatic delineation

Bisgaard

Brink

Fransen

et al. 2022

Physics and Imaging in Radiation Oncology

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Section: Discussionmentioning

confidence: 85%

Robust extraction of biological information from diffusion-weighted magnetic resonance imaging during radiotherapy using semi-automatic delineation

Bisgaard

Brink

Fransen

et al. 2022

Physics and Imaging in Radiation Oncology

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“…Gaetano Paolino et al [19] reported PD-L1 expression usually higher in lymph nodes metastasis than in surgical specimens and lower expression was found in biopsies. Jacob H. Rasmussen [20] considers that the most important factor in the variations of PD-L1 measurement in HNSCC is the heterogenicity of the tumor itself.…”

Section: Discussionmentioning

confidence: 99%

“…CPS classification as high (20), low (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) or negative (<1) was based on the KEYNOTE-048 study [3]. In this study, pembrolizumab with chemotherapy improved OS vs cetuximab with chemotherapy in the patients with CPS of 20 or more and CPS of 1 or more.…”

Section: Methodsmentioning

confidence: 97%

Revisiting the Role of PD-L1 Overexpression in Prognosis and Clinicopathological Features in Patients with Oral Squamous Cell Carcinoma

Leporace-Jimenez,

Portillo-Hernandez,

Jimenez-Almonacid

et al. 2023

Preprint

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Background: PD1 and its ligand PD-L1 are related to the prognosis in many solid tumors, whether its role in oral squamous cell carcinoma (OSCC) remains unclear. Methods: Retrospective monocentric study including all patients with OSCC diagnosed and treated between 01/2020 and 05/2022. PD-L1 expression was assessed by combined positive score (CPS), considering CPS > or equal to 1 as positive (1-20 “low expression”, and ≥20 “high”). Descriptive analysis of patient cohort and tumors was performed, including tumor size, stage, lymph node involvement, recur-rence and survival. Results: 65 patients (65 tumors) were analyzed. 66.15% of tumors were ad-vanced stages (III-IV), of them, 97.67% PD-L1+ versus 71.42% within early stages (I-II). T4 tumors expressed PD-L1 in 100% of cases, compared with 54’54% in T1 tumors. 50.79 % of tumors showed lymph node involvement (pN+), 100% of them showing PD-L1+. Prevalence of pN+ was 59.38% for PD-L1 high expression versus 40.63% for low expression. Patients' follow-up ranged from 2 to 34.5 months. No significant difference was seen between overall survival (OS) and PD-L1 +/- (CPS ≥1 vs CPS <1) neither PD-L1 high (CPS ≥20) vs low CPS <20) (p 0.97 and 0.64, re-spectively). Conclusions: The method used to measure (laboratory test with Dako 22C3 an-ti-PD-L1 primary antibody) PD-L1 was reliable and accurate, with a correlation coefficient be-tween the PD-L1 expression in the biopsy and surgical piece of 0.83 (p 0.0001). CPS≥1 was ob-served in large tumors (p<0.001), and was correlated with of lymph node metastases (p<0.004). Further analysis of PD-L1 expression and its relevance in tumor biology and prognosis is needed.

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“…Although pathological diagnosis is still considered the “gold standard” for detecting gene mutations in cancer lesions, not all lesions are suitable for gene testing through biopsy or surgery in clinical practice. Moreover, due to the heterogeneity of tumous (including intratumoral and intertumoral heterogeneity), tissue specimens obtained by puncture or surgery may not reflect all information on the phenotypes and variations of mutation genes in lesions [ [13] , [14] , [15] ]. Liquid biopsy can obtain mutant genes in plasma, but false-negative results may occur if there is not enough DNA shed into the circulation [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Dual-energy CT-based radiomics in predicting EGFR mutation status non-invasively in lung adenocarcinoma

Ma,

Jiang,

Wang

et al. 2024

Heliyon

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Intratumor heterogeneity is biomarker specific and challenges the association with heterogeneity in multimodal functional imaging in head and neck squamous cell carcinoma

Cited by 8 publications

References 29 publications

Robust extraction of biological information from diffusion-weighted magnetic resonance imaging during radiotherapy using semi-automatic delineation

Robust extraction of biological information from diffusion-weighted magnetic resonance imaging during radiotherapy using semi-automatic delineation

Revisiting the Role of PD-L1 Overexpression in Prognosis and Clinicopathological Features in Patients with Oral Squamous Cell Carcinoma

Dual-energy CT-based radiomics in predicting EGFR mutation status non-invasively in lung adenocarcinoma

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