Intratumoral CD68-, CD117-, CD56-, and CD1a-positive immune cells and the survival of Iranian patients with non-metastatic intestinal-type gastric carcinoma

Amoueian, Sakineh; Attaranzadeh, Armin; Montazer, Mehdi

doi:10.1016/j.prp.2014.12.013

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…Therefore, it may nonetheless be a relatively reliable TAM marker. Nine of the 12 included studies used CD68 as a macrophage marker (Ishigami et al, 2003;Ohno et al, 2005;Haas et al, 2009;Kawahara et al, 2010;Amoueian et al, 2015;Kim et al, 2015;Wu et al, 2015;Zhang et al, 2015Zhang et al, , 2016. The corresponding pooled HR indicated that high levels of CD68 + TAMs correlated with poor OS, but no significant correlation was identified between such cells and DFS.…”

Section: Discussionmentioning

confidence: 99%

“…The full texts of 15 candidate articles were carefully reviewed, with three being excluded as a result (two with inadequate data and one having examined the same patient group as another study). Finally, 12 studies were included in the meta-analysis ( Figure 1; Ishigami et al, 2003;Ohno et al, 2005;Haas et al, 2009;Kawahara et al, 2010;Wang et al, 2011;Amoueian et al, 2015;Kim et al, 2015;Lin et al, 2015;Wu et al, 2015;Park et al, 2016;Zhang et al, 2015Zhang et al, , 2016. In total, 1388 patients from China, Taiwan, Korea, Iran, Japan, and Germany were included.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Four studies incorporated fewer than 100 patients, and three examined over 150 patients. Nine articles reported the prognostic value of total infiltrating TAMs (Ishigami et al, 2003;Ohno et al, 2005;Haas et al, 2009;Kawahara et al, 2010;Amoueian et al, 2015;Kim et al, 2015;Wu et al, 2015;Zhang et al, 2015Zhang et al, , 2016, whereas others focused on specific TAM polarization subsets. Immunohistochemistry was used to detect both total infiltrating TAMs and TAM polarization.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Among the 12 included studies, nine reported the relationship between total infiltrating TAMs and patient survival. Seven of the articles evaluated OS (Ishigami et al, 2003;Haas et al, 2009;Kawahara et al, 2010;Amoueian et al, 2015;Wu et al, 2015;Zhang et al, 2015Zhang et al, , 2016, and two recorded DFS (Ohno et al, 2005;Kim et al, 2015). The pooled HR of the former seven studies indicated that TAM infiltration correlates with worse OS (high CD68 + TAM density vs low CD68 + TAM density, HR = 1.70, 95%CI = 1.39-2.09; P < 0.001; heterogeneity: I 2 = 17.6%, P = 0.295; Figure 2A).…”

Section: Total Infiltrating Tams and Gc Prognosismentioning

confidence: 99%

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Prognostic significance of tumor-associated macrophage infiltration in gastric cancer: a meta-analysis

Wang

Jiang

2016

Genet. Mol. Res.

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Tumor-associated macrophages (TAMs), which play a crucial role in the tumor microenvironment, can be divided into M1 and M2 phenotypes, these phenotypes may exert opposite effects on the prognoses of patients with gastric cancer (GC). The association between TAMs and GC is contentious. Thus, a meta-analysis of 12 studies (incorporating 1388 patients) retrieved from the Cochrane Library, PubMed, and Embase databases was conducted in order to evaluate the relationship between TAMs and GC prognosis. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled to explore the effect of these cells on survival of GC patients. Our results implied that high total TAM infiltration levels correspond to worse overall survival (OS) in patients with GC (HR = 1.70, 95%CI = 1.39-2.09; P < 0.001), and a similar result was observed in relation to M2 macrophage infiltration (HR = 1.71, 95%CI = 1.19-2.45; P = 0.004). In contrast, elevated M1 macrophage density in GC patients was associated with better OS (HR = 0.46, 95%CI = 0.33-0.65; P < 0.001). This meta-analysis showed that the numbers of infiltrating M2 macrophages and total TAMs might be negative prognostic factors for patients with GC, while M1 macrophage infiltration may be associated with a favorable survival rate.

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Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Total Infiltrating Tams and Gc Prognosismentioning

confidence: 99%

See 2 more Smart Citations

Prognostic significance of tumor-associated macrophage infiltration in gastric cancer: a meta-analysis

Wang

Jiang

2016

Genet. Mol. Res.

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“…Recent studies have suggested that the loss of DCs would correlate with tumor progression, lower survival rate, and poor prognosis for patients affected by different human neoplasms, possibly as a consequence of a deficit in the host immune response to tumor growth and a cytotoxic T lymphocytes impairment . This was shown to be true for patients affected by colorectal , gastric , pancreatic , breast , and other human cancers, as well as in experimental animal models . Because of these clinically relevant findings, some DC‐based cancer immunotherapies have been developed, but a meaningful clinical response remains to be achieved .…”

Section: Discussionmentioning

confidence: 99%

CD1a+ and CD83+ Langerhans cells are reduced in lower lip squamous cell carcinoma

Gomes

Carvalho

Fonseca

et al. 2015

J Oral Pathology Medicine

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Abstract:Background: Actinic cheilitis (AC) is a potentially malignant lesion diagnosed in the lip of patients chronically exposed to the sun that may give rise to a fully invasive lower lip squamous cell carcinoma (LLSCC). It is known that ultraviolet radiation causes dendritic cells (DCs) depletion in the epidermis, but the role of this cellular population in lip cancer progression remains uncertain. Therefore, this study investigated the distribution of DCs in normal, dysplastic and neoplastic tissues of the lower lip.

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Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

Becht¹,

Giraldo²,

Germain³

et al. 2016

Advances in Immunology

181

136

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Intratumoral CD68-, CD117-, CD56-, and CD1a-positive immune cells and the survival of Iranian patients with non-metastatic intestinal-type gastric carcinoma

Cited by 9 publications

References 27 publications

Prognostic significance of tumor-associated macrophage infiltration in gastric cancer: a meta-analysis

Prognostic significance of tumor-associated macrophage infiltration in gastric cancer: a meta-analysis

CD1a+ and CD83+ Langerhans cells are reduced in lower lip squamous cell carcinoma

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

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