Intratumoral Heterogeneity in Lung Cancer

Abstract

The diagnosis and treatment of lung cancer (LC) is always a challenge. The difficulty in the decision of therapeutic schedule and diagnosis is directly related to intratumoral heterogeneity (ITH) in the progression of LC. It has been proven that most tumors emerge and evolve under the pressure of their living microenvironment, which involves genetic, immunological, metabolic, and therapeutic components. While most research on ITH revealed multiple mechanisms and characteristic, a systemic exposition of ITH in LC is still hard to find. In this review, we describe how ITH in LC develops from the perspective of space and time. We discuss elaborate details and affection of every aspect of ITH in LC and the relationship between them. Based on ITH in LC, we describe a more accurate multidisciplinary therapeutic strategy on LC and provide the newest opinion on the potential approach of LC therapy.

Búsqueda de biomarcadores pronósticos y terapéuticos en el carcinoma pulmonar de células escamosas. Correlación clínico-patológica

“…En la última década, los estudios masivos de secuenciación no solo han identificado alteraciones genómicas recurrentes a través de grandes cohortes de muestras de CPCE, también ha puesto en evidencia la gran heterogeneidad inter e intratumoral que supone uno de los grandes retos a la hora de definir un perfil molecular específico (64,65). Además, con el paso del tiempo se ha demostrado que el microambiente tumoral juega un papel relevante en la progresión del cáncer de pulmón (66).…”