2019
DOI: 10.21203/rs.2.15684/v1
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Intratumoral reciprocal expression of monocarboxylate transporter 4 and glypican-3 in hepatocellular carcinomas

Abstract: Objective: We previously reported the identification of monocarboxylate transporter 4 (MCT4) and glypican-3 (GPC3) as prognostic factors for hepatocellular carcinoma (HCC), which are now considered significant poor prognostic factors for the disease. This study aimed to clarify the detailed interaction of these two factors in HCC t o improve our understanding of aggressive HCC phenotype s. A total of 225 Japanese patients with HCC from our previous study were subjected to immunohistochemical analyses. Results:… Show more

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Cited by 2 publications
(4 citation statements)
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“…SLC16A3, also known as MCT4, is a member of the monocarboxylic acid transporter (MCT) family. It has been found to be highly expressed in a variety of malignant tumor tissues, such as renal cell renal carcinoma, hepatocellular carcinoma, osteosarcoma, and is associated with patient prognosis (25)(26)(27). DDX4 is an ATP-dependent RNA helicase belonging to the DEAD box protein family, and is also expressed by spermatogonial progenitors.…”
Section: Discussionmentioning
confidence: 99%
“…SLC16A3, also known as MCT4, is a member of the monocarboxylic acid transporter (MCT) family. It has been found to be highly expressed in a variety of malignant tumor tissues, such as renal cell renal carcinoma, hepatocellular carcinoma, osteosarcoma, and is associated with patient prognosis (25)(26)(27). DDX4 is an ATP-dependent RNA helicase belonging to the DEAD box protein family, and is also expressed by spermatogonial progenitors.…”
Section: Discussionmentioning
confidence: 99%
“…Analysis of HCC patients’ serum samples suggested the use of serum LDH as a prognostic factor [ 30 , 31 , 32 , 33 , 34 , 35 ]. High levels of MCT4 and CD147, a transmembrane glycoprotein able to induce matrix metalloprotease (MMP) production and to interact with MCT4 for lactate secretion, were detected in HCC tissues [ 36 , 37 , 38 , 39 ].…”
Section: Hcc and Glucose Metabolismmentioning
confidence: 99%
“…GPC3 is involved in the reprogramming of tumor cell metabolism by acting on the glucose pathway ( Figure 1 ) [ 36 , 37 , 78 , 79 , 80 ]. HCC cells, in presence of high GPC3 protein expression, have a higher glucose uptake and lactate production [ 78 ].…”
Section: Hcc and Glucose Metabolismmentioning
confidence: 99%
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