Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination

Abstract

The iron gall ink-triggered chemical corrosion of hand-written documents is a big threat to Western cultural heritages, which was demonstrated to result from the iron gall (GA-Fe) chelate-promoted reactive oxygen species generation. Such a phenomenon has inspired us to apply the pro-oxidative mechanism of GA-Fe to anticancer therapy. In this work, we construct a composite cancer nanomedicine by loading gallate into a Fe-engineered mesoporous silica nanocarrier, which can degrade in acidic tumor to release the doped Fe3+ and the loaded gallate, forming GA-Fe nanocomplex in situ. The nanocomplex with a highly reductive ligand field can promote oxygen reduction reactions generating hydrogen peroxide. Moreover, the resultant two-electron oxidation form of GA-Fe is an excellent Fenton-like agent that can catalyze hydrogen peroxide decomposition into hydroxyl radical, finally triggering severe oxidative damage to tumors. Such a therapeutic approach by intratumoral synthesis of GA-Fe nano-metalchelate may be instructive to future anticancer researches.

Tumor‐specific and photothermal‐augmented chemodynamic therapy by ferrocene‐carbon dot‐crosslinked nanoparticles

“…1,2 Recently, a variety of nanoparticles have been proved holding biological and physical benefits, including elevated selectivity, enhanced efficacy, and minimized toxicity. 3,4 Thus, ever-increasing attentions have been attracted in construction of functional nanoparticles for application in cancer theranostics, involving polymers, liposomes, and inorganic nanostructures. [5][6][7] Among these designs, carbon dots (CDs) possess great promises thanks to their tunable optical properties, superior biocompatibility, easy surface modification, and most importantly, phototriggered photothermal therapy (PTT) and photodynamic therapy (PDT) potentials.…”

“…Nanomedicine refers to the combination of nanotechnology with biomedical and pharmaceutical sciences, aiming to innovate in the healthcare of patients via exploiting imaging and therapeutic agents with enhanced efficiency and improved safety 1,2 . Recently, a variety of nanoparticles have been proved holding biological and physical benefits, including elevated selectivity, enhanced efficacy, and minimized toxicity 3,4 . Thus, ever‐increasing attentions have been attracted in construction of functional nanoparticles for application in cancer theranostics, involving polymers, liposomes, and inorganic nanostructures 5–7 .…”

Cancer Metabolism: The Role of Immune Cells Epigenetic Alteration in Tumorigenesis, Progression, and Metastasis of Glioma

“…Nanotechnology is a new therapy strategy being used in the treatment of many diseases. The use of nanocarriers to support immune responses has become imperative in cancer therapy ( 163 ). This is because barriers created by the tumor and the presence of cocktails of protein and chemicals in tumor microenvironments induce immune cell reprogramming, which undermines their ability to fight tumors and reduce cancer cells population ( 164 ).…”

Homotypic targeting of immunomodulatory nanoparticles for enhanced peripheral and central immunity

“…Nanoparticles (NP) have been widely explored as carriers of small molecule chemicals and biomolecules. 21 , 22 , 23 , 24 , 25 , 26 Recent studies have demonstrated their superior advantages in the delivery of functional nucleic acids including short interfering RNA (siRNA), viral RNA mimics, and CpG ODNs. As an example, a tumor microenvironment‐responsive nanobooster encapsulates a hybrid RNA encoding both siRNA and viral RNA signature for orchestrated activation of innate immunity and potent induction of long‐term T cell memory, eliciting multilayer antitumor activities.…”