2010
DOI: 10.3892/ijo_00000718
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Intratumoral Wnt1 expression affects survivin gene expression in non-small cell lung cancer

Abstract: Abstract. Survivin, a member of the inhibitor of apoptosis protein family, affects tumorigenesis. Recently, survivin is reported to be a target of the canonical Wnt pathway, which activates the transcription of various tumor-associated target genes. One hundred and twenty-two non-small cell lung cancers (NSCLCs) were investigated to evaluate survivin gene expression in relation to the expression of Wnt1 (a novel member of the canonical Wnt pathway) and Wnt5a (a novel member of the non-canonical Wnt pathway). T… Show more

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Cited by 11 publications
(1 citation statement)
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“…Trk activation by BDNF was shown to enhance the proliferation and survival of transitional cell carcinoma cell lines [9]; conversely, a TrkB antibody induced cytotoxicity and suppressed the migration and invasion of transitional cell carcinoma cells [10]. Although mutations of the TrkB gene have been reported in colorectal cancer [8,11], previous studies have not analyzed the expression and function of TrkB and BDNF in colorectal cancer cell lines or tumor samples.…”
Section: Introductionmentioning
confidence: 99%
“…Trk activation by BDNF was shown to enhance the proliferation and survival of transitional cell carcinoma cell lines [9]; conversely, a TrkB antibody induced cytotoxicity and suppressed the migration and invasion of transitional cell carcinoma cells [10]. Although mutations of the TrkB gene have been reported in colorectal cancer [8,11], previous studies have not analyzed the expression and function of TrkB and BDNF in colorectal cancer cell lines or tumor samples.…”
Section: Introductionmentioning
confidence: 99%