1994
DOI: 10.1177/019459989411000204
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Intratympanic gentamicin in bilateral meniere's disease

Abstract: Treatment of bilateral Menière's disease is a delicate task. Streptomycin has demonstrated its ability to successfully control the vertigo attacks, but in some cases it results in oscillopsia and transforms the periodic attacks to permanent instability. If the site of the active labyrinth can be determined, a more specific treatment can be tried. We have treated 14 patients with intractable bilateral Menière's disease with intratympanic gentamicin (Garamycin, 40 mg/ml) administered initially in either 1, 2, 3,… Show more

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Cited by 52 publications
(44 citation statements)
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“…The drugs were applied on the RW membrane with or without catheter, e.g. corticosteroids and gentamicin [2, 3, 4, 5, 6, 7]. …”
Section: Introductionmentioning
confidence: 99%
“…The drugs were applied on the RW membrane with or without catheter, e.g. corticosteroids and gentamicin [2, 3, 4, 5, 6, 7]. …”
Section: Introductionmentioning
confidence: 99%
“…Systemic streptomycin, however, can produce chronic disequilibrium and oscillopsia, which can be disabling, in up to half of patients [24,25]. Pyykko et al [26] reported role of bilateral intratympanic gentamicin injections in 14 patients with bilateral Meniere's disease. Rotatory vertigo was controlled in all, with no signifi cant change in hearing.…”
Section: Discussionmentioning
confidence: 99%
“…No double-blind studies on gentamicin therapy have been completed to date, but several papers have documented its usefulness in effecting a chemical vestibular ablation, usually without significant hearing loss [23][24][25][26][27].…”
Section: Transtympanic Instillation Of Gentamicinmentioning
confidence: 99%