Intratympanic Steroid Treatment in Idiopathic Sudden Sensorineural Hearing Loss: A Control Study

Xenellis, John; Papadimitriou, Nikolaos; Nikolopoulos, Thomas P.; Maragoudakis, P.; Segas, John; Tzagaroulakis, Antonios; Ferekidis, E.

doi:10.1016/j.otohns.2005.03.081

Cited by 149 publications

(191 citation statements)

References 22 publications

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“…Despite this variability, 3 of the 4 RCTs evaluating intratympanic steroids as salvage therapy found that IT steroids improved hearing outcomes beyond placebo. Hearing improvement occurred in 53% to 90% of patients [29,30] Table 2. IT steroids are to be started on the 1 st day when patient approaches the doctor. It can be used as a main stay of treatment or as an adjuvant treatment with other modalities.…”

Section: Discussionmentioning

confidence: 99%

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Intratympanic Steroids in Sudden Sensorineural Hearing Loss: Myth or Magic?

Taneja

Tatavarty

Gupta

2017

JOENTR

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Sudden Sensorineural hearing loss (SSNHL) is a medical emergency inwhich etiopathogenesis and consensus on treatment are still largely debatable. SSNHL has been defined as 30 dB or more sensorineural hearing loss over at least three contiguous audiometric frequencies occurring within 3 days or less. Although several vascular, inflammatory, viral and neoplastic causes exist, no specific etiology can be confirmed; thereforeit is considered idiopathic. Steroids form the mainstay of treatment; however, recent experience with transtympanic steroid injections has been very encouraging. The exact number of injections, dosage, steroid form and window of application is still to be determined conclusively. We report a rare case of idiopathic SSNHL with profound hearing loss treated by 6 shots of transtympanic injections which normalised the hearing. We also review the methods and improvement of transtympanic injections from other studies.

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Section: Discussionmentioning

confidence: 99%

“…Xenellis, et al [30] IT methylprednisolone (40 mg/mL) with a 21 gauge needle, four times over 15 days.…”

Section: Discussionmentioning

confidence: 99%

Intratympanic Steroids in Sudden Sensorineural Hearing Loss: Myth or Magic?

Taneja

Tatavarty

Gupta

2017

JOENTR

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“…Several others studies have supported IT DEX as salvage therapy, while other lack sufficient evidence of success [9,12,17,19,[20][21][22][23] . Among the factors that could influence hearing outcome, time from onset of HL to the baseline visit was found to be statistically significant (p=0.030).…”

Section: Discussionmentioning

confidence: 99%

The Role of High Dose Intratympanic Dexamethasone as Salvage Therapy for Idiopathic Sudden Sensorineural Hearing Loss

Kordiš

Battelino

2017

Int Adv Otol

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OBJECTIVE:The aim of this study was to assess the efficacy of a single high dose intratympanic (IT) dexamethasone (DEX) as salvage therapy for idiopathic sudden sensorineural hearing loss (ISSNHL) after unsuccessful treatment with oral corticosteroid (CS). MATERIALS and METHODS:This was a prospective open-label study of 59 patients treated with IT DEX after systemic CS therapy has failed. All patients received high dose (24 mg/mL) IT DEX in a single injection through myringotomy. RESULTS:Of the 59 patients, 40.7% showed improvement in their mean pure tone average (PTA) with IT DEX (p=0.005). The difference in the mean PTA after oral CS treatment only from baseline was not statistically significant (p=0.074). The time from onset of hearing loss to the start of therapy was significantly associated with the outcome (p=0.03). CONCLUSION:We determined that high dose IT DEX as salvage therapy was beneficial when the primary treatment with oral CS had failed. An early start of the treatment significantly influenced the improvement of hearing.

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“…Other authors have also described the use of intratympanic corticosteroids for the treatment of SHL. 9,[12][13][14][15][16][17][18][19][20][21][23][24][25][26][27] Although its efficacy alone has not been proved definitively, intratympanic corticosteroid therapy for SHL is becoming more widely used. The variability among treatment protocols for SHL also applies to intratympanic corticosteroid therapy.…”

Section: Intratympanic Therapymentioning

confidence: 99%

“…13,15,16 Most studies about intratympanic corticosteroids for treating SHL report having attempted this mode of therapy after systemic corticosteroid therapy has failed. 9,[12][13][14][15][16][17][18][19][20][21][25][26][27] Two studies evaluated the effects of intratympanic corticosteroids as adjuvant therapy to systemic corticosteroids in SHL patients. 23,24 There are several advantages of using intratympanic corticosteroids (see Frame I).…”

Section: Intratympanic Therapymentioning

confidence: 99%

Metilprednisolona intratimpânica como terapia de resgate na surdez neurossensorial súbita

Raymundo¹,

Bahmad²,

Filho³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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Treat ment in sudden sensorineural hearing loss is a contentious issue, today, oral steroids are the most common choice and considered the best treatment option, but the use of intratympanic steroids has become an attractive alternative, especially in cases when systemic therapy fails, or to avoid the side effects of the systemic use of steroids. Aim:To describe the results of intratympanic methylprednisolone in idiopathic sudden sensorineural hearing loss after failure of oral prednisolone.Methods: In a prospective study fourteen patients with idiopathic sudden sensorineural hearing loss were treated with intratympanic methylprednisolone after failing in the treatment with systemic steroids. Pretreatment and post-treatment audiometric evaluations including pure tone average (PTA) and speech reception thresholds (SRT) were analyzed. Results:Ten from 14 patients treated with intra-tympanic methylprednisolone presented with hearing recovery > 20 dB in PTA or 20% in SRT. Conclusion:Three intratympanic injections of methylprednisolone improved pure-tone average or speech discrimination scores for a subset of sudden hearing loss subjects that failed to benefit from oral steroids. Braz J Otorhinolaryngol. 2010;76(4):499-509. ORIGINAL ARTICLE BJORL

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Intratympanic Steroid Treatment in Idiopathic Sudden Sensorineural Hearing Loss: A Control Study

Abstract: IT steroid administration after failed intravenous steroids is a safe and effective treatment in sudden sensorineural hearing loss.

Cited by 149 publications

References 22 publications

Intratympanic Steroids in Sudden Sensorineural Hearing Loss: Myth or Magic?

Intratympanic Steroids in Sudden Sensorineural Hearing Loss: Myth or Magic?

The Role of High Dose Intratympanic Dexamethasone as Salvage Therapy for Idiopathic Sudden Sensorineural Hearing Loss

Metilprednisolona intratimpânica como terapia de resgate na surdez neurossensorial súbita

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