Intrauterine alcohol and nicotine exposure: Attention and reaction time in 4-year-old children.

Streissguth, Ann P.

doi:10.1037/0012-1649.20.4.533

Cited by 207 publications

(118 citation statements)

References 21 publications

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“…For the most part, previous studies have reported an association between behavioral problems, such as hyperactivity and decreased attention spans, and maternal smoking during pregnancy (7,(17)(18)(19)(20)(21)(22). Only one study, which had an insufficient number of heavy smokers (23), did not report such a relationship.…”

mentioning

confidence: 69%

“…Only one study, which had an insufficient number of heavy smokers (23), did not report such a relationship. The association with behavioral problems has been shown in investigations of hyperactive children and controls (17), sibling studies in which the mother smoked in one pregnancy but not in the other (7), and in neuropsychologic evaluations of children of smokers and nonsmokers using tests of sustained vigilance and attention (20)(21)(22). Naeye and Peters (7) found that hemoglobin levels in neonates increased with the number of cigarettes smoked by the mother during her pregnancy, and that children who were more active or who had shorter attention spans had significantly higher hemoglobin levels.…”

mentioning

confidence: 99%

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Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children.

Eskenazi

Castorina

1999

Environ Health Perspect

186

111

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We review the potential neurodevelopmental and behavioral effects of children's prenatal and/or postnatal exposure to environmental tobacco smoke (ETS). Children's exposure to ETS has been assessed in epidemiologic studies as a risk factor for a variety of behavioral and neurodevelopmenta problems induding reduced general intellectual ability, skills in language and auditory tasks, and academic achievement, and behavioral problems such as hyperactivity and decrease attention spans. We review 17 epidemiologic studies that have attempted to separate the efcs of maternal active smoking during pregnancy from passive ETS smoke exposure by the pregnant mother or the child. Based on the available data, we found that ETS exposure could cause subtle changes in children's neurodevelopment and behavior. However, studies to date are difficult to interpret because of the unknown influence of uncontrolled confounding factors, imprecision in measurements of smoking exposure, and coilinearity of pre-and postnatal maternal smoking. Although some evidence suggests that maternal smoking during pregnancy may be associated with deficits in intellectual ability and behavioral problems in children, the impact of prenatal or postnatal ETS exposure remains less dear.

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mentioning

confidence: 69%

mentioning

confidence: 99%

Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children.

Eskenazi

Castorina

1999

Environ Health Perspect

186

111

View full text Add to dashboard Cite

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“…Streissguth and colleagues found evidence for a long-term effect of alcohol, but not nicotine or caffeine, in children assessed at 8 months [61], 4 years of age [62], and 7 years [63]. Maternal consumption of 4.8 mg of caffeine / kg body weight / day during pregnancy resulted in moderate plasma concentrations of caffeine, but did not affect newborns' Apgar scores [59].…”

Section: Discussionmentioning

confidence: 99%

Effects of discontinuing coffee intake on iron deficient Guatemalan toddlers' cognitive development and sleep

Engle

VasDias

Howard³

et al. 1999

Early Human Development

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Coffee is commonly given daily to toddlers in Guatemala. Possible negative effects of coffee ingestion on cognitive development and sleep patterns were assessed in 132 children 12-24 months of age who had received coffee for . 2 months and were iron deficient on at least one indicator. Children were stratified by initial hemoglobin (A 5 anemic, Hgb , 10.5 g / dl; NA 5 'non-anemic', Hgb $ 10.5 g / dl) and were randomly assigned to an experimental group treatment on test scores or BRS ratings were found. In the 24 h period reported on at the final visit, children in the Substitute group slept more during the night and overall (night plus naps) than children in the Coffee group, a difference not found at the first visit. No differences were (S 5 substitute consisting of sugar and coloring), and a control group (C 5 continuation of coffee) (42 C-NA; 53 S-NA; 18 C-A; and 19 S-A). Anemic children were provided Fe supplements for 2-3 months. Compliance was assessed every 2 weeks. After 5 months, testers masked to treatment group and anemia evaluated children with the Bayley Scales of Infant Development II in a central location. Scores were the Mental Development Index (MDI), the Psychomotor Development Index (PDI), and scales from the Behavior Rating Scale (BRS). The child's sleep in the previous 24 h was assessed with a set of standardized sleep questions to the care giver on the first visit and every 2 weeks thereafter. No significant effects of found in sleep difficulty or number of times waking at night. Women's reported coffee intake per day during pregnancy was associated with lower BRS ratings, even after controlling for SES and child age. The effects of postnatal coffee ingestion in Guatemala were seen for sleep duration, but not for cognitive development. Prenatal coffee ingestion was negatively associated with Behavior Rating Scales and should be investigated further.

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“…However, a similar study on a US cohort was only able to identify a synergistic effect of prenatal alcohol and tobacco exposure on birthweight in infants of mothers greater than 30 years of age (Jacobson et al, 1994). In addition to affecting growth, a synergistic affect of alcohol and tobacco use was identified on attention and reaction time in 454 4-year old children (Streissguth et al, 1984), raising the possibility that other phenotypes may also be affected. Further work is required to elucidate the exact circumstances in which a synergistic effect between alcohol and tobacco may occur.…”

Section: Evidence In Humansmentioning

confidence: 98%

A study of the consequences of early gestational ethanol and/or nicotine exposure in the mouse

Yamada¹

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The in utero environment is a critical determinant of the immediate and future health of the developing fetus. In Australia, two of the most commonly used drugs during pregnancy are alcohol and nicotine. Prolonged periods of gestational exposure to alcohol and nicotine, separately, have been associated with a range of adverse outcomes in the offspring, in both humans and experimental animal models. The consequences of ethanol and nicotine exposure restricted to early gestation on resultant offspring are poorly characterised, and few animal models exist to build greater understanding. Moreover, the immediate molecular changes associated with exposures to ethanol and/or nicotine restricted to early gestation has yet to be described.This thesis utilised mouse models of early gestational ethanol and/or nicotine exposure to explore the impact of each of these exposures on offspring growth, as well as their associated transcriptional and epigenetic changes. In each model, pregnant C57BL/6 dams were provided with ad libitum access to solutions of 10% ethanol and/or 100 µg/ml nicotine from fertilisation (0.5 dpc) to midgestation (8.5 dpc). The exposure window utilised in each of the models is developmentally equivalent to the first three to four weeks of a human pregnancy.Previously, our laboratory identified reduced growth, microcephaly, and gene expression changes in the liver and hippocampus of the postnatal offspring of the model of prenatal ethanol exposure utilised in this thesis. In contrast, at mid-gestation (9.5 dpc), there was no evidence of developmental delay (somite number), reduced growth (crown-rump length), or microcephaly.Further, a genome-wide gene expression microarray (targeting 30 855 genes) and a screen of the expression of 641 microRNAs, identified only one gene (Bcl11b) as differentially expressed in male 9.5 dpc whole embryos following the ethanol exposure. These data suggest that there is a delay between the ethanol exposure and the onset of adverse phenotypes -arguing that the embryo is somehow able to form a memory of the ethanol exposure. The absence of widespread transcriptional changes suggests that changes in embryonic mRNA and microRNA expression are unlikely to be major contributors to the memory of the exposure.A early gestational model of nicotine exposure was newly established in this thesis. This nicotine exposure resulted in an average serum cotinine (metabolite of nicotine) concentration similar to that reported in humans who smoke 10 to 15 cigarettes per day. This exposure was sufficient to induce a reduction in body size both at mid-gestation and postnatally, but not at late gestation. Furthermore, the increased expression of Zscan10 in the whole male 9.5 dpc embryo was identified and validated across multiple cohorts. Zscan10 encodes for a transcription factor expressed throughout development, with a proposed role in the regulation of progenitor cells. The increased expression of Zscan10 in the nicotine-exposed embryos was associated with a reduction in DNA methylation ...

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Intrauterine alcohol and nicotine exposure: Attention and reaction time in 4-year-old children.

Cited by 207 publications

References 21 publications

Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children.

Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children.

Effects of discontinuing coffee intake on iron deficient Guatemalan toddlers' cognitive development and sleep

A study of the consequences of early gestational ethanol and/or nicotine exposure in the mouse

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