Intrauterine Blood Flow and Long-Term Intellectual, Neurologic, and Social Development

Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction

“…In children delivered later (median, 34 weeks' gestation) findings were different. At 6 years of age, ARED flow survivors scored lower in 20-22% of fine motor and neuropediatric tests and had significantly lower scores in all domains of the Kaufman assessment battery for children 102 . Kaufman scores correlated with birth weight, and REDV survivors tended to have lower scores than did those with AEDV.…”

“…These associations have been documented for early-and late-onset FGR independent of Doppler parameters 127 . The overall severity of growth delay, expressed in absolute birth weight or as a low birth-weight percentile, correlates predominantly with parameters of motor development in infancy and early childhood 99,102,127,128,130 and to a lesser degree with social and cognitive scales 94 . These associations are reported for early-onset FGR independent of Doppler parameters and BPS.…”

Maternal Periodontal Infections, Prematurity, and Growth Restriction

“…The quality of the environment, as well as the duration of the gestation in utero, has been suggested to be a critical determinant of longterm well being of the individual, ranging from cognitive and learning skills to susceptibility of heart disease. 11 Maternal infections during pregnancy and attendant inflammatory responses have been linked to specific neonatal problems, including periventricular leukomalacia, (PVL, white matter necrosis), respiratory distress (often leading to chronic lung disease of preterm birth) and cerebral palsy. 12 Furthermore, increasing evidence suggests that the molecular and cellular inflammatory effector pathways that underlie the pathogenesis of preterm birth are also involved in growth restriction and developmental problems ranging from respiratory distress to cognitive and learning disabilities.…”

Dépistage et programmation de la naissance des fœtus présentant un retard de croissance intra-utérin d'origine vasculaire

“…Le taux de mortalité périnatale augmente graduellement avec la sévérité des anomalies du Doppler ombilical (index élevé, diastole nulle, inversion de flux) [13][14][15]. Par ailleurs, l'existence d'une diastole nulle ou d'une inversion de flux a été associée à un risque accru de retard neurodéveloppemental [16,17]. L'utilité du Doppler ombilical pour la surveillance des grossesses dans les populations à risques a été clairement démontrée, son utilisation conduisant à une réduction significative de la mortalité périnatale [18].…”